Sheehan's syndrome natural history, complications and prognosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Sheehan's syndrome}} | {{Sheehan's syndrome}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{IQ}} | ||
==Overview== | ==Overview== | ||
[[Sheehan's syndrome]] leads to [[hypopituitarism]] and [[empty sella syndrome]], if left untreated. Common complications are including [[adrenal crisis]], [[hypotension]], [[hypothyroidism]], and [[hypopituitarism]]. [[Prognosis]] is generally excellent provided early diagnosis and management resulting in complete reversal of symptoms. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
* | *Sheehan's syndrom<nowiki/>e usually results in [[anterior pituitary]] shrinkage within 20 days, followed by disappearance of pituitary tissue in 6-8 week; resulting in [[hypopituitarism]] and [[empty sella syndrome]]. | ||
*The symptoms of | *The symptoms of [[Sheehan's syndrome]] can develop during immediate post-puerperal period to years after delivery. | ||
*If left untreated, [ | *It may result in sparing or reversal of gonadotropic dysfunction as few cases of successful pregnancies have been reported following Sheehan's syndrome.<ref name="pmid11273296">{{cite journal |vauthors=Zargar AH, Masoodi SR, Laway BA, Sofi FA, Wani AI |title=Pregnancy in Sheehan's syndrome: a report of three cases |journal=J Assoc Physicians India |volume=46 |issue=5 |pages=476–8 |year=1998 |pmid=11273296 |doi= |url=}}</ref><ref name="pmid6745465">{{cite journal |vauthors=Moreira AC, Zanini Maciel LM, Foss MC, Tabosa Veríssimo JM, Iazigi N |title=Gonadotropin secretory capacity in a patient with Sheehan's syndrome with successful pregnancies |journal=Fertil. Steril. |volume=42 |issue=2 |pages=303–5 |year=1984 |pmid=6745465 |doi= |url=}}</ref> | ||
*If left untreated, lead to [[mitral regurgitation]], [[pericardial effusion]], and diminished left ventricular motion, [[Adrenal crisis|adrenal crisi]]<nowiki/>s, [[hypopituitarism]], and [[empty sella syndrome]].<ref name="pmid27359291">{{cite journal |vauthors=Laway BA, Ramzan M, Allai MS, Wani AI, Misgar RA |title=CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY |journal=Endocr Pract |volume=22 |issue=9 |pages=1096–103 |year=2016 |pmid=27359291 |doi=10.4158/EP161262.OR |url=}}</ref> | |||
===Complications=== | ===Complications=== | ||
*Common complications of [ | *Common complications of Sheehan's syndrome are including: | ||
**[ | **[[Adrenal crisis]] | ||
**[ | **[[Hypotension]] | ||
**[ | **[[Hypothyroidism]] | ||
**[[Menstrual irregularities]] | |||
**[[Empty sella syndrome]] | |||
===Prognosis=== | ===Prognosis=== | ||
* | *[[Prognosis]] is generally good, and results in reversal of symptoms once respective [[hormones]] are being replaced. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Obstetrics]] | |||
Latest revision as of 00:09, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
Sheehan's syndrome leads to hypopituitarism and empty sella syndrome, if left untreated. Common complications are including adrenal crisis, hypotension, hypothyroidism, and hypopituitarism. Prognosis is generally excellent provided early diagnosis and management resulting in complete reversal of symptoms.
Natural History, Complications, and Prognosis
Natural History
- Sheehan's syndrome usually results in anterior pituitary shrinkage within 20 days, followed by disappearance of pituitary tissue in 6-8 week; resulting in hypopituitarism and empty sella syndrome.
- The symptoms of Sheehan's syndrome can develop during immediate post-puerperal period to years after delivery.
- It may result in sparing or reversal of gonadotropic dysfunction as few cases of successful pregnancies have been reported following Sheehan's syndrome.[1][2]
- If left untreated, lead to mitral regurgitation, pericardial effusion, and diminished left ventricular motion, adrenal crisis, hypopituitarism, and empty sella syndrome.[3]
Complications
- Common complications of Sheehan's syndrome are including:
Prognosis
- Prognosis is generally good, and results in reversal of symptoms once respective hormones are being replaced.
References
- ↑ Zargar AH, Masoodi SR, Laway BA, Sofi FA, Wani AI (1998). "Pregnancy in Sheehan's syndrome: a report of three cases". J Assoc Physicians India. 46 (5): 476–8. PMID 11273296.
- ↑ Moreira AC, Zanini Maciel LM, Foss MC, Tabosa Veríssimo JM, Iazigi N (1984). "Gonadotropin secretory capacity in a patient with Sheehan's syndrome with successful pregnancies". Fertil. Steril. 42 (2): 303–5. PMID 6745465.
- ↑ Laway BA, Ramzan M, Allai MS, Wani AI, Misgar RA (2016). "CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY". Endocr Pract. 22 (9): 1096–103. doi:10.4158/EP161262.OR. PMID 27359291.