Hamartoma surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [3]


Surgery is the mainstay of therapy for hamartomas. There are different anatomic approaches for different anatomic sites.


Pulmonary Hamartoma

Hypothalamic Hamartoma

  • Hypothalamic hamartomas can be effectively treated with a variety of surgical approaches.
  • The most effective approach is the magnetic resonance imaging (MRI)-guided stereotactic laser ablation (SLA).
  • This approach offers a a potentially safer, minimally invasive method with high efficacy for the hypothalamic hamartoma treatment.[2]
  • Other specific surgical options include; stereotactic thermocoagulation, gamma knife radiosurgery, and physical resection by transsphenoidal microsurgery.
  • Surgery is normally offered if there is a rapid growth of lesion.
  • Surgical response is typically better when the seizure focus has been found by EEG to originate in or near the mass.
  • The specific location of the lesion relative to the pituitary and infundibulum and the amount of hormonal disturbance at presentation can help predict risk of hypopituitarism following surgery.[3]

Cardiac Hamartoma

  • Complete surgical excision is the main choice surgery for symptomatic patients with cardiac hamartoma.
  • Other intervention may be partial excision. However, this procedure is only indicated when the tumor size is more extensive.
  • Postsurgical recurrence is rare.[4]

Kidneys, Spleen, and Other Vascular Organs Hamartomas


  1. Guo W, Zhao YP, Jiang YG, Wang RW, Ma Z (2008). "Surgical treatment and outcome of pulmonary hamartoma: a retrospective study of 20-year experience". J. Exp. Clin. Cancer Res. 27: 8. doi:10.1186/1756-9966-27-8. PMC 2438336. PMID 18577258.
  2. Wilfong AA, Curry DJ (2013). "Hypothalamic hamartomas: optimal approach to clinical evaluation and diagnosis". Epilepsia. 54 Suppl 9: 109–14. doi:10.1111/epi.12454. PMID 24328883.
  3. Pascual-Castroviejo I, Moneo JH, Viaño J, García-Segura JM, Herguido MJ, Pascual Pascual SI (2000). "[Hypothalamic hamartomas: control of seizures after partial removal in one case]". Rev Neurol (in Spanish). 31 (2): 119–22. PMID 10951665.
  4. Bradshaw SH, Hendry P, Boodhwani M, Dennie C, Veinot JP (2011). "Left ventricular mesenchymal hamartoma, a new hamartoma of the heart". Cardiovasc. Pathol. 20 (5): 307–14. doi:10.1016/j.carpath.2010.07.007. PMID 20850353.
  5. Habermalz B, Sauerland S, Decker G, Delaitre B, Gigot JF, Leandros E, Lechner K, Rhodes M, Silecchia G, Szold A, Targarona E, Torelli P, Neugebauer E (2008). "Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)". Surg Endosc. 22 (4): 821–48. doi:10.1007/s00464-007-9735-5. PMID 18293036.
  6. Loffroy, R; Rao, P; Kwak, BK; Ota, S; De Lin, M; Liapi, E; Geschwind, JF (May–Jun 2010). "Transcatheter arterial [[embolization]] in patients with kidney diseases: an overview of the technical aspects and clinical indications" (PDF). Korean journal of radiology : official journal of the Korean Radiological Society. 11 (3): 257–68. doi:10.3348/kjr.2010.11.3.257. PMC 2864852. PMID 20461179. URL–wikilink conflict (help)

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