Hamartoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Vamsikrishna Gunnam M.B.B.S [3]


The incidence of pulmonary hamartoma is approximately 0.25% in general population. The incidence of other hamartomas remains unknown. Pulmonary hamartomas are estimated to be 8% of all lung neoplasms. Most lesions are diagnosed incidentally. Hamartomatous syndromes are usually first diagnosed among adolescents and adult patients. In general, most hamartomas affect males more commonly than females.

Epidemiology and Demographics



  • Pulmonary hamartomas are usually first diagnosed among patients in the 4th and 7th decades of life.[2]
  • Bone islands often occur in children than adults.
  • Pulmonary hamartomas are very uncommon in children.[2]
  • Hypothalamic hamartomas are usually first diagnosed during puberty.[6]
  • Cardiac hamartomas are usually first diagnosed among adolescents and young adults.[7]
  • Kidney hamartomas are usually first diagnosed among middle age adults.[8]


  • Males are more commonly affected with pulmonary hamartomas than females. The male to female ratio is approximately 3 to 1.[2]
  • Males are slightly more affected with hypothalamic hamartomas than females. The male to female ratio is approximately 1.3 to 1.
  • Females are more commonly affected with kidney hamartomas than males. The female to male ratio is approximately 4 to 1.
  • Cardiac hamartoma affects males and females equally.
  • Osteosarcomas most commonly affect males than females.



  1. Guo W, Zhao YP, Jiang YG, Wang RW, Ma Z (2008). "Surgical treatment and outcome of pulmonary hamartoma: a retrospective study of 20-year experience". Journal of Experimental & Clinical Cancer Research : CR. 27: 8. doi:10.1186/1756-9966-27-8. PMC 2438336. PMID 18577258.
  2. 2.0 2.1 2.2 2.3 Hansen CP, Holtveg H, Francis D, Rasch L, Bertelsen S (1992). "Pulmonary hamartoma". J. Thorac. Cardiovasc. Surg. 104 (3): 674–8. PMID 1513155.
  3. Gjevre JA, Myers JL, Prakash UB (January 1996). "Pulmonary hamartomas". Mayo Clin. Proc. 71 (1): 14–20. doi:10.1016/S0025-6196(11)64915-X. PMID 8538225.
  4. Murray J, Kielkowski D, Leiman G (1991). "The prevalence and age distribution of peripheral pulmonary hamartomas in adult males. An autopsy-based study". S. Afr. Med. J. 79 (5): 247–9. PMID 2011801.
  5. Pulmonary hamartoma.Dr Henry Radiopedia.http://radiopaedia.org/articles/pulmonary-hamartoma-1 Accessed on December 08,2015
  6. Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS (2003). "Hypothalamic hamartomas: seven cases and review of the literature". Epilepsy Behav. 4 (3): 246–58. PMID 12791326.
  7. Torimitsu S, Nemoto T, Wakayama M, Okubo Y, Yokose T, Kitahara K, Ozawa T, Nakayama H, Shinozaki M, Sasai D, Ishiwatari T, Takuma K, Shibuya K (2012). "Literature survey on epidemiology and pathology of cardiac fibroma". Eur. J. Med. Res. 17: 5. doi:10.1186/2047-783X-17-5. PMC 3351722. PMID 22472419.
  8. Eble JN (1998). "Angiomyolipoma of kidney". Seminars in Diagnostic Pathology. 15 (1): 21–40. PMID 9503504.
  9. Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, Suby-Long T, Ocazionez D, Vargas D (March 2017). "Hamartomas from head to toe: an imaging overview". Br J Radiol. 90 (1071): 20160607. doi:10.1259/bjr.20160607. PMC 5601532. PMID 27936889.

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