Pituitary gland

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Pituitary gland
Located at the base of the brain, the pituitary gland is protected by a bony structure called the sella turcica(also known as turkish saddle)of the sphenoid bone.
Median sagittal through the hypophysis of an adult monkey. Semidiagrammatic.
Latin hypophysis, glandula pituitaria
Gray's subject #275 1275
Artery superior hypophyseal artery, infundibular artery, prechiasmal artery, inferior hypophyseal artery, capsular artery, artery of the inferior cavernous sinus[1]
Precursor neural and oral ectoderm, including Rathke's pouch
MeSH Pituitary+Gland
Dorlands/Elsevier h_22/12439692

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The pituitary gland, or hypophysis, is an endocrine gland about the size of a pea that sits in a small, bony cavity (sella turcica) covered by a dural fold (diaphragma sellae) at the base of the brain. The pituitary fossa, in which the pituitary gland sits, is situated in the sphenoid bone in the middle cranial fossa at the base of the brain.

The pituitary gland secretes hormones regulating homeostasis, including trophic hormones that stimulate other endocrine glands. It is functionally connected to the hypothalamus by the median eminence.

The hypophysis is also the top cell of the suspensor in a dicot embryo, which will differentiate to form part of the root cap.


Located at the base of the brain, the pituitary is functionally linked to the hypothalamus. It is composed of two lobes: the adenohypophysis and neurohypophysis. The adenohypophysis, also referred to as the anterior pituitary is divided into anatomical regions known as the pars tuberalis and pars distalis. The neurohypophysis, also referred to as the posterior pituitary. The pituitary is functionally linked to the hypothalamus by the pituitary stalk, whereby hypothalamic releasing factors are released and in turn stimulate the release of pituitary hormones.

Anterior pituitary (Adenohypophysis)

The anterior lobe is derived from the oral ectoderm and is composed of glandular epithelium. The anterior pituitary is functionally linked to the hypothalamus via the hypophysial-portal vascular connection in the pituitary stalk. Through this vascular connection the hypothalamus integrates stimulatory and inhibitory central and peripheral signals to the five phenotypically distinct pituitary cell types.

The anterior pituitary synthesizes and secretes important endocrine hormones, such as ACTH, TSH, prolactin, growth hormone, endorphins, FSH, and LH. These hormones are released from the anterior pituitary under the influence of hypothalamic hormones. The hypothalamic hormones travel to the anterior lobe by way of a special capillary system, called the hypothalamic-hypophyseal portal system.

Posterior pituitary (Neurohypophysis)

The posterior lobe is connected to the hypothalamus via the infundibulum or pituitary stalk, giving rise to the tuberoinfundibular pathway. Hormones are made in nerve cell bodies positioned in the hypothalamus, and these hormones are then transported down the nerve cell's axons to the posterior pituitary.

The hormones secreted by the posterior pituitary are

Oxytocin is the only pituitary hormone to create a positive feedback loop. For example, uterine contractions stimulate the release of oxytocin from the posterior pituitary, which in turn increases uterine contractions. This positive feedback loop continues until the baby is born.

Intermediate lobe

There is also a intermediate lobe in many animals. For instance in fish it is believed to control physiological colour change. In adult humans it is just a thin layer of cells between the anterior and posterior pituitary. The intermediate lobe produces melanocyte-stimulating hormone (MSH), although this function is often (imprecisely) attributed to the anterior pituitary.


The pituitary hormones help control some of the following body processes:


Disorders involving the pituitary gland include:

Condition Direction Hormone
Acromegaly overproduction growth hormone
Growth hormone deficiency underproduction growth hormone
Syndrome of inappropriate antidiuretic hormone overproduction vasopressin
Diabetes insipidus underproduction vasopressin
Sheehan syndrome underproduction prolactin
Pituitary adenoma overproduction any pituitary hormone
Hypopituitarism underproduction any pituitary hormone

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See also


  1. Gibo H, Hokama M, Kyoshima K, Kobayashi S (1993). "[Arteries to the pituitary]". Nippon Rinsho. 51 (10): 2550–4. PMID 8254920.

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| group5 = Clinical Trials Involving Pituitary gland | list5 = Ongoing Trials on Pituitary gland at Clinical Trials.govTrial results on Pituitary glandClinical Trials on Pituitary gland at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pituitary gland | list6 = US National Guidelines Clearinghouse on Pituitary glandNICE Guidance on Pituitary glandNHS PRODIGY GuidanceFDA on Pituitary glandCDC on Pituitary gland

| group7 = Textbook Information on Pituitary gland | list7 = Books and Textbook Information on Pituitary gland

| group8 = Pharmacology Resources on Pituitary gland | list8 = AND (Dose)}} Dosing of Pituitary glandAND (drug interactions)}} Drug interactions with Pituitary glandAND (side effects)}} Side effects of Pituitary glandAND (Allergy)}} Allergic reactions to Pituitary glandAND (overdose)}} Overdose information on Pituitary glandAND (carcinogenicity)}} Carcinogenicity information on Pituitary glandAND (pregnancy)}} Pituitary gland in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Pituitary gland

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Pituitary gland | list9 = AND (pharmacogenomics)}} Genetics of Pituitary glandAND (pharmacogenomics)}} Pharmacogenomics of Pituitary glandAND (proteomics)}} Proteomics of Pituitary gland

| group10 = Newstories on Pituitary gland | list10 = Pituitary gland in the newsBe alerted to news on Pituitary glandNews trends on Pituitary gland

| group11 = Commentary on Pituitary gland | list11 = Blogs on Pituitary gland

| group12 = Patient Resources on Pituitary gland | list12 = Patient resources on Pituitary glandDiscussion groups on Pituitary glandPatient Handouts on Pituitary glandDirections to Hospitals Treating Pituitary glandRisk calculators and risk factors for Pituitary gland

| group13 = Healthcare Provider Resources on Pituitary gland | list13 = Symptoms of Pituitary glandCauses & Risk Factors for Pituitary glandDiagnostic studies for Pituitary glandTreatment of Pituitary gland

| group14 = Continuing Medical Education (CME) Programs on Pituitary gland | list14 = CME Programs on Pituitary gland

| group15 = International Resources on Pituitary gland | list15 = Pituitary gland en EspanolPituitary gland en Francais

| group16 = Business Resources on Pituitary gland | list16 = Pituitary gland in the MarketplacePatents on Pituitary gland

| group17 = Informatics Resources on Pituitary gland | list17 = List of terms related to Pituitary gland

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