GAIN Trial
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
GAIN Trial
- GAIN trial studied the effects of atorvastatin on the progression of atherosclerosis, assessed by intra-coronary ultrasound (IVUS) in 131 patients.
- After a 12 month follow-up period, it was found that atorvastatin reduced the progression of mean plaque volume (1.2 versus 9.6 mm3 for placebo). Also, the drug increased hyperechogenicity of the plaque which indicates a change in plaque composition from lipid-rich core to fibrotic or calcified. This change in composition of the plaque corresponds to increased plaque stability and a reduced tendency for rupture.[1]
References
- ↑ Schartl M, Bocksch W, Koschyk DH; et al. (2001). "Use of intravascular ultrasound to compare effects of different strategies of lipid-lowering therapy on plaque volume and composition in patients with coronary artery disease". Circulation. 104 (4): 387–92. PMID 11468198. Unknown parameter
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