Chromosome 15 (human)
|Chromosome 15 (human)|
|File:Human male karyotpe high resolution - Chromosome 15 cropped.png|
Human chromosome 15 pair after G-banding.
One is from mother, one is from father.
|File:Human male karyotpe high resolution - Chromosome 15.png|
Chromosome 15 pair
in human male karyogram.
|Length (bp)||101,991,189 bp|
|No. of genes||561 (CCDS)|
|Complete gene lists|
|External map viewers|
|Full DNA sequences|
Chromosome 15 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 15 spans about 101 million base pairs (the building material of DNA) and represents between 3% and 3.5% of the total DNA in cells.
The human leukocyte antigen gene for β2-microglobulin is found at chromosome 15.
The following are some of the gene count estimates of human chromosome 15. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
|Estimated by||Protein-coding genes||Non-coding RNA genes||Pseudogenes||Source||Release date|
The following are some of the genes located on chromosome 15:
- AAGAB: alpha- and gamma-adaptin binding protein
- ACSBG1: encoding enzyme Acyl-CoA Synthetase, Bubblegum Family, member 1
- ARPP-19: encoding protein cAMP-regulated phosphoprotein 19
- C15orf15: encoding protein Probable ribosome biogenesis protein RLP24
- C15orf29: encoding protein Uncharacterized protein C15orf29
- CAPN3: Calpain 3 (limb-girdle muscular dystrophy type 2A)
- CHP: Calcium binding protein P22
- CHSY1: Chondroitin sulfate synthase 1
- CLK3: CDC like kinase 3
- ClpX: encoding enzyme ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
- COMMD4: encoding protein COMM domain-containing protein 4
- CPEB1: Cytoplasmic polyladenylation element binding protein 1
- ELL3: encoding protein Elongation factor RNA polymerase II-like 3
- EYCL2 Eye color 2, Determines the positioning of melanocytes on the iris (note eye color is a polygenic trait)
- EYCL3 Eye color 3, BROWN & BLUE - location: 15q11-q15 (note eye color is a polygenic trait) 
- FAH: fumarylacetoacetate hydrolase (fumarylacetoacetase)
- FAM214A: encoding protein Protein FAM214A
- FBN1: fibrillin 1 (Marfan syndrome)
- FOXB1: encoding protein Forkhead box B1
- GATM: Glycine aminotransferase, mitochondrial
- GCHFR: GTP cyclohydrolase 1 feedback regulatory protein
- GLCE: D-glucuronyl C5-epimerase
- HEXA: hexosaminidase A (alpha polypeptide)(Tay-Sachs disease)
- HMG20A: encoding protein High mobility group protein 20A
- IDDM3 encoding protein Insulin dependent diabetes mellitus 3
- IMP3: encoding protein U3 small nucleolar ribonucleoprotein protein IMP3
- ITPKA: encoding enzyme Inositol-trisphosphate 3-kinase A
- IVD: isovaleryl Coenzyme A dehydrogenase
- LARP6 encoding protein La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6),
- LCMT2: encoding enzyme Leucine carboxyl methyltransferase 2
- LINC00926 encoding protein Long intergenic non-protein coding RNA 926
- MESDC2: encoding protein LDLR chaperone MESD
- MESP1: encoding protein Mesoderm posterior 1 homolog (mouse)
- MFAP1: encoding protein Microfibrillar-associated protein 1
- MCPH4: microcephaly, primary autosomal recessive 4
- MIR7-2: encoding protein MicroRNA 7-2
- MIR627: encoding protein MicroRNA 627
- NIPA2: encoding protein Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
- OCA2: oculocutaneous albinism II (pink-eye dilution homolog, mouse)
- PDCD7: encoding protein Programmed cell death protein 7
- PML: promyelocytic leukemia protein (involved in t(15,17) with RARalpha, predominant cause of acute promyelocytic leukemia.
- PTPLAD1: encoding enzyme Protein tyrosine phosphatase-like protein PTPLAD1
- PYGO1: encoding protein Pygopus homolog 1 (Drosophila)
- RAD51: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
- RMDN3: encoding protein Regulator of microtubule dynamics protein 3
- RNR3: encoding RNA, ribosomal 45S cluster 3
- RTF1: encoding protein Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
- SCAMP2: encoding protein Secretory carrier-associated membrane protein 2
- SCAMP5: encoding protein Secretory carrier-associated membrane protein 5
- SCZD10: encoding protein Schizophrenia disorder 10 (periodic catatonia)
- SENP8: encoding enzyme Sentrin-specific protease 8
- SERF2: encoding protein Small EDRK-rich factor 2
- SLC24A5: the gene responsible for at least 1/3 of the skin color differences between races, expressed in the brain and the nervous system
- SNAPC5: encoding protein snRNA-activating protein complex subunit 5
- SPN1: encoding protein Snurportin1
- STRC: stereocilin
- SUHW4: encoding protein Zinc finger protein 280D
- TMC3: encoding protein Transmembrane channel like 3
- TMCO5A: encoding protein Transmembrane and coiled-coil domains 5A
- TMED3: encoding protein Transmembrane p24 trafficking protein 3
- UBE3A: ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
- VPS39: encoding protein hVam6p/Vps39-like protein
- ZNF592: encoding protein Zinc finger protein 592
- UNC13C: encoding protein unc-13 homolog C
The following conditions are caused by mutations in chromosome 15. Two of the conditions (Angelman syndrome and Prader-Willi syndrome) involve a loss of gene activity in the same part of chromosome 15, the 15q11.2-q13.1 region. This discovery provided the first evidence in humans that something beyond genes could determine how the genes are expressed.
The main characteristics of Angelman syndrome are severe mental retardation, ataxia, lack of speech, and excessively happy demeanor. Angelman syndrome results from a loss of gene activity in a specific part of chromosome 15, the 15q11-q13 region. This region contains a gene called UBE3A that, when mutated or absent, likely causes the characteristic features of this condition. People normally have two copies of the UBE3A gene, one from each parent. Both copies of this gene are active in many of the body's tissues. In the brain, however, only the copy inherited from a person's mother (the maternal copy) is active. If the maternal copy is lost because of a chromosomal change or a gene mutation, a person will have no working copies of the UBE3A gene in the brain.
In most cases (about 70%), people with Angelman syndrome have a deletion in the maternal copy of chromosome 15. This chromosomal change deletes the region of chromosome 15 that includes the UBE3A gene. Because the copy of the UBE3A gene inherited from a person's father (the paternal copy) is normally inactive in the brain, a deletion in the maternal chromosome 15 results in no active copies of the UBE3A gene in the brain.
In 3% to 7% of cases, Angelman syndrome occurs when a person has two copies of the paternal chromosome 15 instead of one copy from each parent. This phenomenon is called paternal uniparental disomy (UPD). People with paternal UPD for chromosome 15 have two copies of the UBE3A gene, but they are both inherited from the father and are therefore inactive in the brain.
About 10% of Angelman syndrome cases are caused by a mutation in the UBE3A gene, and another 3% result from a defect in the DNA region that controls the activation of the UBE3A gene and other genes on the maternal copy of chromosome 15. In a small percentage of cases, Angelman syndrome may be caused by a chromosomal rearrangement called a translocation or by a mutation in a gene other than UBE3A. These genetic changes can abnormally inactivate the UBE3A gene.
Angelman syndrome can be hereditary, as evidenced by one case where a patient became pregnant with a daughter who also had the condition.
The main characteristics of this condition include polyphagia (extreme, insatiable appetite), mild to moderate developmental delay, hypogonadism resulting in delayed to no puberty, and hypotonia. Prader-Willi syndrome is caused by the loss of active genes in a specific part of chromosome 15, the 15q11-q13 region. People normally have two copies of this chromosome in each cell, one copy from each parent. Prader-Willi syndrome occurs when the paternal copy is partly or entirely missing.
In about 70% of cases, Prader-Willi syndrome occurs when the 15q11-q13 region of the paternal chromosome 15 is deleted. The genes in this region are normally active on the paternal copy of the chromosome and are inactive on the maternal copy. Therefore, a person with a deletion in the paternal chromosome 15 will have no active genes in this region.
In about 25% of cases, a person with Prader-Willi syndrome has two maternal copies of chromosome 15 in each cell instead of one copy from each parent. This phenomenon is called maternal uniparental disomy. Because some genes are normally active only on the paternal copy of this chromosome, a person with two maternal copies of chromosome 15 will have no active copies of these genes.
In a small percentage of cases, Prader-Willi syndrome is not caused by a chromosomal rearrangement called a trans location. Rarely, the condition is caused by an abnormality in the DNA region that controls the activity of genes on the paternal chromosome 15. Because patients almost always have difficulty reproducing, Prader-Willi syndrome is generally not hereditary.
Isodicentric chromosome 15
A specific chromosomal change called an isodicentric chromosome 15 (previously called[when?] an inverted duplication 15) can affect growth and development. The patient possesses an "extra" or "marker" chromosome. This small extra chromosome is made up of genetic material from chromosome 15 that has been abnormally duplicated (copied) and attached end-to-end. In some cases, the extra chromosome is very small and has no effect on a person's health. A larger isodicentric chromosome 15 can result in weak muscle tone (hypotonia), mental retardation, seizures, and behavioral problems. Signs and symptoms of autism (a developmental disorder that affects communication and social interaction) have also been associated with the presence of an isodicentric chromosome 15.
Other chromosomal conditions
Other changes in the number or structure of chromosome 15 can cause mental retardation, delayed growth and development, hypotonia, and characteristic facial features. These changes include an extra copy of part of chromosome 15 in each cell (partial trisomy 15) or a missing segment of the chromosome in each cell (partial monosomy 15). In some cases, several of the chromosome's DNA building blocks (nucleotides) are deleted or duplicated.
The following diseases are some of those related to genes on chromosome 15:
- Bloom syndrome
- Breast cancer
- Isovaleric acidemia
- Loeys-Dietz, type 3 (SMAD3 gene)
- Marfan syndrome
- Nonsyndromic deafness
- Tay-Sachs disease
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This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (September 2009) (Learn how and when to remove this template message)
- ↑ "Human Genome Assembly GRCh38 - Genome Reference Consortium". National Center for Biotechnology Information. 2013-12-24. Retrieved 2017-03-04.
- ↑ 2.0 2.1 "Search results - 15[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene". NCBI. CCDS Release 20 for Homo sapiens. 2016-09-08. Retrieved 2017-05-28.
- ↑ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.
- ↑ 4.0 4.1 Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
- ↑ Pertea M, Salzberg SL (2010). "Between a chicken and a grape: estimating the number of human genes". Genome Biol. 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615.
- ↑ "Statistics & Downloads for chromosome 15". HUGO Gene Nomenclature Committee. 2017-05-12. Retrieved 2017-05-19.
- ↑ "Chromosome 15: Chromosome summary - Homo sapiens". Ensembl Release 88. 2017-03-29. Retrieved 2017-05-19.
- ↑ "Search results - 15[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
- ↑ "Search results - 15[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
- ↑ "Search results - 15[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
- ↑ "Teacher's Guide". Ghost in Your Genes (season 35). Nova (TV series). October 16, 2007. Retrieved 2009-09-26.
The program...recounts how one scientist determined how the deletion of a key sequence of DNA on human chromosome 15 could lead to two different syndromes depending on whether the deletion originated from the mother or the father [and] explains that this was the first human evidence that something other than genes themselves could determine how genes are expressed.
- ↑ Lossie A, Driscoll D (1999). "Transmission of Angelman syndrome by an affected mother". Genet Med. 1 (6): 262–6. doi:10.1097/00125817-199909000-00004. PMID 11258627.
- ↑ "What is Dup15q Syndrome? - Dup15q". www.dup15q.org. Retrieved 2017-09-05.
- ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
- ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
- ↑ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7.
- ↑ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images" (PDF). In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on: 276–282. doi:10.1109/JCSSE.2012.6261965.
- ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
- ↑ "p": Short arm; "q": Long arm.
- ↑ For cytogenetic banding nomenclature, see article locus.
- ↑ 21.0 21.1 These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
- ↑ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
- Bittel DC, Butler MG (2005). "Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology". Expert Rev Mol Med. 7 (14): 1–20. doi:10.1017/S1462399405009531. PMID 16038620.
- Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG (2003). "Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD". J Med Genet. 40 (8): 568–574. doi:10.1136/jmg.40.8.568. PMC 1735542. PMID 12920063.
- Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG (2005). "Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD". Genomics. 85 (1): 85–91. doi:10.1016/j.ygeno.2004.10.010. PMID 15607424.
- Borgatti R, Piccinelli P, Passoni D, Dalpra L, Miozzo M, Micheli R, Gagliardi C, Balottin U (2001). "Relationship between clinical and genetic features in "inverted duplicated chromosome 15" patients". Pediatr Neurol. 24 (2): 111–116. doi:10.1016/S0887-8994(00)00244-7. PMID 11275459.
- Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T (2004). "Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy". Pediatrics. 113 (3 Pt 1): 565–573. doi:10.1542/peds.113.3.565. PMID 14993551.
- Cassidy SB, Dykens E, Williams CA (2000). "Prader-Willi and Angelman syndromes: sister imprinted disorders". Am J Med Genet. 97 (2): 136–146. doi:10.1002/1096-8628(200022)97:2<136::AID-AJMG5>3.0.CO;2-V. PMID 11180221.
- Clayton-Smith J, Laan L (2003). "Angelman syndrome: a review of the clinical and genetic aspects". J Med Genet. 40 (2): 87–95. doi:10.1136/jmg.40.2.87. PMC 1735357. PMID 12566516.
- Gilbert F (1999). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 15". Genet Test. 3 (3): 309–322. doi:10.1089/109065799316653. PMID 10495933.
- Lee S, Wevrick R (2000). "Identification of novel imprinted transcripts in the Prader-Willi syndrome and Angelman syndrome deletion region: further evidence for regional imprinting control". Am J Hum Genet. 66 (3): 848–858. doi:10.1086/302817. PMC 1288168. PMID 10712201.
- Rineer S, Finucane B, Simon EW (1998). "Autistic symptoms among children and young adults with isodicentric chromosome 15". Am J Med Genet. 81 (5): 428–433. doi:10.1002/(SICI)1096-8628(19980907)81:5<428::AID-AJMG12>3.0.CO;2-E. PMID 9754629.
- Zollino M, Tiziano F, Di Stefano C, Neri G (1999). "Partial duplication of the long arm of chromosome 15: confirmation of a causative role in craniosynostosis and definition of a 15q25-qter trisomy syndrome". Am J Med Genet. 87 (5): 391–394. doi:10.1002/(SICI)1096-8628(19991222)87:5<391::AID-AJMG4>3.0.CO;2-O. PMID 10594876.
|Wikimedia Commons has media related to Human chromosome 15.|
- National Institutes of Health. "Chromosome 15". Genetics Home Reference. Retrieved 2017-05-06.
- "Chromosome 15". Human Genome Project Information Archive 1990–2003. Retrieved 2017-05-06.
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- Chromosomes (human)
- Genes on human chromosome 15