Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1gene.[1][2]
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
↑Welk JF, Charlesworth A, Smith GD, MacNicol AM (Mar 2001). "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein". Gene. 263 (1–2): 113–20. doi:10.1016/S0378-1119(00)00588-6. PMID11223249.
Mendez R, Richter JD (2001). "Translational control by CPEB: a means to the end". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. doi:10.1038/35080081. PMID11433366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Wilczynska A, Aigueperse C, Kress M, et al. (2005). "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules". J. Cell Sci. 118 (Pt 5): 981–92. doi:10.1242/jcs.01692. PMID15731006.
Sasayama T, Marumoto T, Kunitoku N, et al. (2005). "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1". Genes Cells. 10 (7): 627–38. doi:10.1111/j.1365-2443.2005.00870.x. PMID15966895.
