Catecholaminergic polymorphic ventricular tachycardia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mounika Reddy Vadiyala, M.B.B.S.[2]

Overview

Syncope triggered by exercise or emotion is the initial manifestation in the majority of the cases of catecholaminergic polymorphic ventricular tachycardia. Sudden cardiac death during exercise or emotion may also be the initial manifestation in a relevant proportion of cases. Most of the patients have a positive family history of CPVT or sudden cardiac death.

History and Symptoms

Clinical presentation of Catecholaminergic polymorphic ventricular tachycardia is variable, including asymptomatic patients identified as a part of familial screening.

History

Patients with Catecholaminergic polymorphic ventricular tachycardia may have a positive history of:

Patients with Catecholaminergic polymorphic ventricular tachycardia may have a positive family history of:

Common Symptoms

Common symptoms of catecholaminergic polymorphic ventricular tachycardia include:

Less Common Symptoms

Less common symptoms of catecholaminergic polymorphic ventricular tachycardia include

References

  1. Leenhardt, Antoine; Lucet, Vincent; Denjoy, Isabelle; Grau, Francis; Ngoc, Dien Do; Coumel, Philippe (1995). "Catecholaminergic Polymorphic Ventricular Tachycardia in Children". Circulation. 91 (5): 1512–1519. doi:10.1161/01.CIR.91.5.1512. ISSN 0009-7322.
  2. 2.0 2.1 Priori, Silvia G.; Napolitano, Carlo; Memmi, Mirella; Colombi, Barbara; Drago, Fabrizio; Gasparini, Maurizio; DeSimone, Luciano; Coltorti, Fernando; Bloise, Raffaella; Keegan, Roberto; Cruz Filho, Fernando E.S.; Vignati, Gabriele; Benatar, Abraham; DeLogu, Angelica (2002). "Clinical and Molecular Characterization of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia". Circulation. 106 (1): 69–74. doi:10.1161/01.CIR.0000020013.73106.D8. ISSN 0009-7322.
  3. Napolitano, Carlo (May 2007). "Diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia" (PDF). Heart Rhythm. 4 (5): 675–8. doi:10.1016/j.hrthm.2006.12.048. PMID 17467641. Retrieved 2008-12-17. Unknown parameter |coauthors= ignored (help)[dead link]
  4. Tester, David J.; Spoon, Daniel B.; Valdivia, Hector H.; Makielski, Jonathan C.; Ackerman, Michael J. (2004). "Targeted Mutational Analysis of the RyR2-Encoded Cardiac Ryanodine Receptor in Sudden Unexplained Death: A Molecular Autopsy of 49 Medical Examiner/Coroner's Cases". Mayo Clinic Proceedings. 79 (11): 1380–1384. doi:10.4065/79.11.1380. ISSN 0025-6196.
  5. Sumitomo, N (2003). "Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden death". Heart. 89 (1): 66–70. doi:10.1136/heart.89.1.66. ISSN 0007-0769.

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