Brucellosis Principles of diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac Vishal Devarkonda, M.B.B.S[2]


There is no specific diagnostic criteria for brucellosis, principles of diagnosis is based on the history of potential exposure, presentation consistent with the disease and supporting laboratory findings.

Diagnostic Criteria

There is no specific diagnostic criteria for Brucellosis, diagnosis is based on:[1][2][3][4][5][6][7][8][9][10]

  • History of potential exposure
  • Presentation consistent with the disease
  • Supporting laboratory findings


  1. Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9, 2016
  2. Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M; et al. (1996). "Complications associated with Brucella melitensis infection: a study of 530 cases". Medicine (Baltimore). 75 (4): 195–211. PMID 8699960.
  3. Mantur BG, Amarnath SK, Shinde RS (2007). "Review of clinical and laboratory features of human brucellosis". Indian J Med Microbiol. 25 (3): 188–202. PMID 17901634.
  4. Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005). "Brucellosis". N Engl J Med. 352 (22): 2325–36. doi:10.1056/NEJMra050570. PMID 15930423.
  5. Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management". Curr Clin Top Infect Dis. 15: 115–28. PMID 7546364.
  6. Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J (2012). "Clinical manifestations of human brucellosis: a systematic review and meta-analysis". PLoS Negl Trop Dis. 6 (12): e1929. doi:10.1371/journal.pntd.0001929. PMC 3516581. PMID 23236528.
  7. Geyik MF, Gür A, Nas K, Cevik R, Saraç J, Dikici B; et al. (2002). "Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases". Swiss Med Wkly. 132 (7–8): 98–105. doi:2002/07/smw-09900 Check |doi= value (help). PMID 11971204.
  8. Mousa AM, Bahar RH, Araj GF, Koshy TS, Muhtaseb SA, al-Mudallal DS; et al. (1990). "Neurological complications of brucella spondylitis". Acta Neurol Scand. 81 (1): 16–23. PMID 2330811.
  9. Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E (2003). "Brucellosis and the respiratory system". Clin Infect Dis. 37 (7): e95–9. doi:10.1086/378125. PMID 13130417.
  10. Herrick JA, Lederman RJ, Sullivan B, Powers JH, Palmore TN (2014). "Brucella arteritis: clinical manifestations, treatment, and prognosis". Lancet Infect Dis. 14 (6): 520–6. doi:10.1016/S1473-3099(13)70270-6. PMC 4498663. PMID 24480149.