Aplastic anemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:

• Moderately severe aplastic anemia or non severe AA (nSAA)
• Severe aplastic anemia (SAA)
• Very severe aplastic anemia(vSAA)

Classification of aplastic anemia (two out of three criteria must be met)

	nSAA	SAA	vSAA
Reticulocytes	<20G/L	<20G/L	<20G/L
Platelets	<50 G / L	<20G/L	<20G/L
Neutrophilic granulocytes	<1.0 G / L	<0.5G/L	0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

Classification based on the presumed etiology

Classification based on the presumed etiology

Acquired aplastic anemia	Idiopathic
	Secondary	Irradiation Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold salts, NSAIDS. Idiosyncratic reactions Viruses: Epstein Barr virus, parvovirus B19, HIV Immune diseases Pregnancy PNH Paroxysmal nocturnal hemoglobinuria
Inherited aplastic anemia		Fanconi anemia Dyskeratosis congenita Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome