AMG-1

AMG-1
	File:AMG-1.png
Gene therapy
Clinical data
Physiological data
Legal status
Pharmacokinetic data
Identifiers
	IUPAC name (6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl- 6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol;
PubChem Template:Abbreviation	10830874;
Chemical and physical data
Formula	C23H30O2
Molar mass	338.482 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3;

AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a Ki of 0.6nM at CB₁ vs 3.1nM at CB₂.^[1]

Template:Pharm-stub

References

↑ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753

Template:WikiDoc Sources

[1] Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753

[1]

AMG-1

References

Navigation menu

Search