AM-855

AM-855

File:AM-855.png
Gene therapy
Clinical data
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name (4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol
PubChem Template:Abbreviation	10091328
Chemical and physical data
Formula	C26H38O2
Molar mass	382.577 g/mol
3D model (JSmol)	Interactive image
SMILES Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC

AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a Ki of 22.3nM at CB₁ and 58.6nM at CB₂.

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