VIPR1

Vasoactive intestinal peptide receptor 1
Identifiers
Symbols	VIPR1 ; II; FLJ41949; HVR1; PACAP-R-2; RDC1; VAPC1; VIPR; VIRG; VPAC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3399
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VIPR1 205019 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vasoactive intestinal peptide receptor 1, also known as VIPR1, is a human gene.

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.

See also

• Vasoactive intestinal peptide receptor

Further reading

• "[Quaternary structure of rabbit skeletal muscle glycogen synthetase]". Dokl. Akad. Nauk SSSR. 222 (4): 997–1000. 1975. PMID 807467.
• Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2939–43. PMID 7708752.CS1 maint: Multiple names: authors list (link)
• Couvineau A, Gaudin P, Maoret JJ; et al. (1995). "Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP". Biochem. Biophys. Res. Commun. 206 (1): 246–52. PMID 7818527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gagnon AW, Aiyar N, Elshourbagy NA (1994). "Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor". Cell. Signal. 6 (3): 321–33. PMID 7917790.CS1 maint: Multiple names: authors list (link)
• Sreedharan SP, Patel DR, Xia M; et al. (1994). "Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways". Biochem. Biophys. Res. Commun. 203 (1): 141–8. PMID 8074647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Couvineau A, Rouyer-Fessard C, Darmoul D; et al. (1994). "Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains". Biochem. Biophys. Res. Commun. 200 (2): 769–76. PMID 8179610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moody TW, Zia F, Draoui M; et al. (1993). "A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4345–9. PMID 8389448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.CS1 maint: Multiple names: authors list (link)
• Couvineau A, Fabre C, Gaudin P; et al. (1996). "Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane". Biochemistry. 35 (6): 1745–52. doi:10.1021/bi952022h. PMID 8639654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pozo D, Guerrero JM, Segura JJ, Calvo JR (1997). "Thymosin alpha 1 interacts with the VIP receptor-effector system in rat and mouse immunocompetent cells". Immunopharmacology. 34 (2–3): 113–23. PMID 8886855.CS1 maint: Multiple names: authors list (link)
• Couvineau A, Maoret JJ, Rouyer-Fessard C; et al. (1999). "Cloning and functional characterization of the human VIP1/PACAP receptor promoter". Ann. N. Y. Acad. Sci. 865: 59–63. PMID 9927997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knudsen SM, Tams JW, Wulff BS, Fahrenkrug J (1999). "Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production". Ann. N. Y. Acad. Sci. 865: 259–65. PMID 9928020.CS1 maint: Multiple names: authors list (link)
• Marie J, Wakkach A, Coudray A; et al. (1999). "Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients". J. Immunol. 162 (4): 2103–12. PMID 9973484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mimuro H, Suzuki T, Suetsugu S; et al. (2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nicole P, Maoret JJ, Couvineau A; et al. (2000). "Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding". Biochem. Biophys. Res. Commun. 276 (2): 654–9. doi:10.1006/bbrc.2000.3375. PMID 11027527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bajo AM, Juarranz MG, Valenzuela P; et al. (2001). "Expression of vasoactive intestinal peptide (VIP) receptors in human uterus". Peptides. 21 (9): 1383–8. PMID 11072126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lara-Marquez M, O'Dorisio M, O'Dorisio T; et al. (2001). "Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells". J. Immunol. 166 (4): 2522–30. PMID 11160313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin Shreeve S (2002). "Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling". Biochem. Biophys. Res. Commun. 290 (4): 1300–7. doi:10.1006/bbrc.2002.6342. PMID 11812005.
• Dorsam G, Goetzl EJ (2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros". J. Biol. Chem. 277 (16): 13488–93. doi:10.1074/jbc.M107922200. PMID 11812772.
• Branch DR, Valenta LJ, Yousefi S; et al. (2002). "VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection". AIDS. 16 (3): 309–19. PMID 11834941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.