Somatostatin receptor 3

Somatostatin receptor 3
Identifiers
Symbols	SSTR3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20285
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SSTR3 214491 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Somatostatin receptor 3, also known as SSTR3, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Reisine T, Law SF; et al. (1993). "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Mol. Endocrinol. 6 (12): 2136–42. PMID 1337145.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corness JD, Demchyshyn LL, Seeman P; et al. (1993). "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Lett. 321 (2–3): 279–84. PMID 8097479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Law SF, Zaina S, Sweet R; et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Mol. Pharmacol. 45 (4): 587–90. PMID 8183236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1–2): 53–9. PMID 8405411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharma K, Patel YC, Srikant CB (1997). "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Mol. Endocrinol. 10 (12): 1688–96. PMID 8961277.CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. PMID 9177396.CS1 maint: Multiple names: authors list (link)
• de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997). "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". J. Biol. Chem. 272 (38): 23769–74. PMID 9295322.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Talme T, Ivanoff J, Hägglund M; et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. PMID 11472428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferone D, Pivonello R, Van Hagen PM; et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Notaro A, Bonavolonta' G; et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. PMID 12414882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dizeyi N, Konrad L, Bjartell A; et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urol. Oncol. 7 (3): 91–8. PMID 12474541.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• somatostatin+receptor+3 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:WikiDoc Sources