SCN3A: Difference between revisions

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{{Infobox_gene}}
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'''Sodium channel, voltage-gated, type III, alpha subunit''' ('''SCN3A''') is a  [[protein]] that in humans is encoded by the '''Nav1.3''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6328| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SCN3A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1byy.
| PDB = {{PDB2|1byy}}
| Name = Sodium channel, voltage-gated, type III, alpha subunit
| HGNCid = 10590
| Symbol = SCN3A
| AltSymbols =; KIAA1356; NAC3; Nav1.3
| OMIM = 182391
| ECnumber = 
| Homologene = 56005
| MGIid = 98249
| GeneAtlas_image1 = PBB_GE_SCN3A_210432_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005248 |text = voltage-gated sodium channel activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0001518 |text = voltage-gated sodium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6328
    | Hs_Ensembl = ENSG00000153253
    | Hs_RefseqProtein = NP_001075145
    | Hs_RefseqmRNA = NM_001081676
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 165652286
    | Hs_GenLoc_end = 165768799
    | Hs_Uniprot = Q9NY46
    | Mm_EntrezGene = 20269
    | Mm_Ensembl = ENSMUSG00000057182
    | Mm_RefseqmRNA = XM_001001516
    | Mm_RefseqProtein = XP_001001516
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 65295680
    | Mm_GenLoc_end = 65337515
    | Mm_Uniprot = 
  }}
}}
'''Sodium channel, voltage-gated, type III, alpha subunit''' ('''SCN3A'''), also known as '''Nav1.3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6328| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6328| accessdate = }}</ref>
| summary_text = Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
 
SCN3A is the only sodium channel transcript which is changed after nerve injury.
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Catterall WA, Goldin AL, Waxman SG |title=International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 397-409 |year= 2006 |pmid= 16382098 |doi= 10.1124/pr.57.4.4 }}
*{{cite journal  | vauthors=Catterall WA, Goldin AL, Waxman SG |title=International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 397–409 |year= 2006 |pmid= 16382098 |doi= 10.1124/pr.57.4.4 }}
*{{cite journal | author=Malo MS, Srivastava K, Andresen JM, ''et al.'' |title=Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2975-9 |year= 1994 |pmid= 8159690 |doi=  }}
*{{cite journal   |vauthors=Malo MS, Srivastava K, Andresen JM, etal |title=Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2975–9 |year= 1994 |pmid= 8159690 |doi=10.1073/pnas.91.8.2975  | pmc=43497 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Lu CM, Brown GB |title=Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit. |journal=J. Mol. Neurosci. |volume=10 |issue= 1 |pages= 67-70 |year= 1998 |pmid= 9589372 |doi=  }}
*{{cite journal  | vauthors=Lu CM, Brown GB |title=Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit |journal=J. Mol. Neurosci. |volume=10 |issue= 1 |pages= 67–70 |year= 1998 |pmid= 9589372 |doi=10.1007/BF02737087 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 }}
*{{cite journal | author=Gotthardt M, Trommsdorff M, Nevitt MF, ''et al.'' |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616-24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200 }}
*{{cite journal   |vauthors=Gotthardt M, Trommsdorff M, Nevitt MF, etal |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200 }}
*{{cite journal | author=Chen YH, Dale TJ, Romanos MA, ''et al.'' |title=Cloning, distribution and functional analysis of the type III sodium channel from human brain. |journal=Eur. J. Neurosci. |volume=12 |issue= 12 |pages= 4281-9 |year= 2001 |pmid= 11122339 |doi=  }}
*{{cite journal   |vauthors=Chen YH, Dale TJ, Romanos MA, etal |title=Cloning, distribution and functional analysis of the type III sodium channel from human brain |journal=Eur. J. Neurosci. |volume=12 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11122339 |doi=10.1046/j.1460-9568.2000.01336.x }}
*{{cite journal | author=Kasai N, Fukushima K, Ueki Y, ''et al.'' |title=Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus. |journal=Gene |volume=264 |issue= 1 |pages= 113-22 |year= 2001 |pmid= 11245985 |doi=  }}
*{{cite journal   |vauthors=Kasai N, Fukushima K, Ueki Y, etal |title=Genomic structures of SCN2A and SCN3A – candidate genes for deafness at the DFNA16 locus |journal=Gene |volume=264 |issue= 1 |pages= 113–22 |year= 2001 |pmid= 11245985 |doi=10.1016/S0378-1119(00)00594-1 }}
*{{cite journal | author=Whitaker WR, Faull RL, Dragunow M, ''et al.'' |title=Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. |journal=Neuroscience |volume=106 |issue= 2 |pages= 275-85 |year= 2001 |pmid= 11566500 |doi=  }}
*{{cite journal   |vauthors=Whitaker WR, Faull RL, Dragunow M, etal |title=Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus |journal=Neuroscience |volume=106 |issue= 2 |pages= 275–85 |year= 2001 |pmid= 11566500 |doi=10.1016/S0306-4522(01)00212-3 }}
*{{cite journal | author=Weiss LA, Escayg A, Kearney JA, ''et al.'' |title=Sodium channels SCN1A, SCN2A and SCN3A in familial autism. |journal=Mol. Psychiatry |volume=8 |issue= 2 |pages= 186-94 |year= 2003 |pmid= 12610651 |doi= 10.1038/sj.mp.4001241 }}
*{{cite journal   |vauthors=Weiss LA, Escayg A, Kearney JA, etal |title=Sodium channels SCN1A, SCN2A and SCN3A in familial autism |journal=Mol. Psychiatry |volume=8 |issue= 2 |pages= 186–94 |year= 2003 |pmid= 12610651 |doi= 10.1038/sj.mp.4001241 }}
*{{cite journal | author=Shah BS, Rush AM, Liu S, ''et al.'' |title=Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface. |journal=J. Neurosci. |volume=24 |issue= 33 |pages= 7387-99 |year= 2004 |pmid= 15317864 |doi= 10.1523/JNEUROSCI.0322-04.2004 }}
*{{cite journal   |vauthors=Shah BS, Rush AM, Liu S, etal |title=Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface |journal=J. Neurosci. |volume=24 |issue= 33 |pages= 7387–99 |year= 2004 |pmid= 15317864 |doi= 10.1523/JNEUROSCI.0322-04.2004 }}
*{{cite journal | author=Thimmapaya R, Neelands T, Niforatos W, ''et al.'' |title=Distribution and functional characterization of human Nav1.3 splice variants. |journal=Eur. J. Neurosci. |volume=22 |issue= 1 |pages= 1-9 |year= 2005 |pmid= 16029190 |doi= 10.1111/j.1460-9568.2005.04155.x }}
*{{cite journal   |vauthors=Thimmapaya R, Neelands T, Niforatos W, etal |title=Distribution and functional characterization of human Nav1.3 splice variants |journal=Eur. J. Neurosci. |volume=22 |issue= 1 |pages= 1–9 |year= 2005 |pmid= 16029190 |doi= 10.1111/j.1460-9568.2005.04155.x }}
*{{cite journal | author=Platoshyn O, Remillard CV, Fantozzi I, ''et al.'' |title=Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells. |journal=Pflugers Arch. |volume=451 |issue= 2 |pages= 380-7 |year= 2006 |pmid= 16052353 |doi= 10.1007/s00424-005-1478-3 }}
*{{cite journal   |vauthors=Platoshyn O, Remillard CV, Fantozzi I, etal |title=Identification of Functional Voltage-gated Na+ Channels in Cultured Human Pulmonary Artery Smooth Muscle Cells |journal=Pflugers Arch. |volume=451 |issue= 2 |pages= 380–7 |year= 2006 |pmid= 16052353 |doi= 10.1007/s00424-005-1478-3 | pmc=1351366 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal  | author=Martin MS, Tang B, Ta N, Escayg A |title=Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences. |journal=Genomics |volume=90 |issue= 2 |pages= 225-35 |year= 2007 |pmid= 17544618 |doi= 10.1016/j.ygeno.2007.04.006 }}
*{{cite journal  | vauthors=Martin MS, Tang B, Ta N, Escayg A |title=Characterization of 5′ untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences |journal=Genomics |volume=90 |issue= 2 |pages= 225–35 |year= 2007 |pmid= 17544618 |doi= 10.1016/j.ygeno.2007.04.006 | pmc=2637551 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|SCN3A+protein,+human}}
* {{MeshName|SCN3A+protein,+human}}
{{PDB Gallery|geneid=6328}}
{{Ion channels|g2}}
{{NLM content}}
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[[Category:Sodium channels]]


{{membrane-protein-stub}}
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{{NLM content}}
{{Ion channels}}
[[Category:Ion channels]]
{{WikiDoc Sources}}

Revision as of 05:59, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the Nav1.3 gene.[1]

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

SCN3A is the only sodium channel transcript which is changed after nerve injury.

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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