Pancreatic islet cell carcinoma: Difference between revisions
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=== Natural history === | === Natural history === | ||
* The cancer usually presents with [[jaundice]], [[Acholic stools|light-colored stools]], [[Urine|dark urine]], [[pain]] in the upper or middle [[abdomen]] and back, unexplained [[weight loss]], [[anorexia]], [[fatigue]] and symptoms according to the hormone produced<ref name="pmid15258206">{{cite journal| author=Graves TD, Gandhi S, Smith SJ, Sisodiya SM, Conway GS| title=Misdiagnosis of seizures: insulinoma presenting as adult-onset seizure disorder. | journal=J Neurol Neurosurg Psychiatry | year= 2004 | volume= 75 | issue= 8 | pages= 1091-2 | pmid=15258206 | doi=10.1136/jnnp.2003.029249 | pmc=1739168 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15258206 }} </ref><ref name="pmid25984844">{{cite journal| author=de Mestier L, Hentic O, Cros J, Walter T, Roquin G, Brixi H et al.| title=Metachronous hormonal syndromes in patients with pancreatic neuroendocrine tumors: a case-series study. | journal=Ann Intern Med | year= 2015 | volume= 162 | issue= 10 | pages= 682-9 | pmid=25984844 | doi=10.7326/M14-2132 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25984844 }} </ref><ref name="pmid20087335">{{cite journal| author=Zerbi A, Falconi M, Rindi G, Delle Fave G, Tomassetti P, Pasquali C et al.| title=Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic cases. | journal=Am J Gastroenterol | year= 2010 | volume= 105 | issue= 6 | pages= 1421-9 | pmid=20087335 | doi=10.1038/ajg.2009.747 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20087335 }} </ref> | * The cancer usually presents with [[jaundice]], [[Acholic stools|light-colored stools]], [[Urine|dark urine]], [[pain]] in the upper or middle [[abdomen]] and back, unexplained [[weight loss]], [[anorexia]], [[fatigue]] and symptoms according to the hormone produced.<ref name="pmid15258206">{{cite journal| author=Graves TD, Gandhi S, Smith SJ, Sisodiya SM, Conway GS| title=Misdiagnosis of seizures: insulinoma presenting as adult-onset seizure disorder. | journal=J Neurol Neurosurg Psychiatry | year= 2004 | volume= 75 | issue= 8 | pages= 1091-2 | pmid=15258206 | doi=10.1136/jnnp.2003.029249 | pmc=1739168 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15258206 }} </ref><ref name="pmid25984844">{{cite journal| author=de Mestier L, Hentic O, Cros J, Walter T, Roquin G, Brixi H et al.| title=Metachronous hormonal syndromes in patients with pancreatic neuroendocrine tumors: a case-series study. | journal=Ann Intern Med | year= 2015 | volume= 162 | issue= 10 | pages= 682-9 | pmid=25984844 | doi=10.7326/M14-2132 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25984844 }} </ref><ref name="pmid20087335">{{cite journal| author=Zerbi A, Falconi M, Rindi G, Delle Fave G, Tomassetti P, Pasquali C et al.| title=Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic cases. | journal=Am J Gastroenterol | year= 2010 | volume= 105 | issue= 6 | pages= 1421-9 | pmid=20087335 | doi=10.1038/ajg.2009.747 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20087335 }} </ref> | ||
* Patients with VIPoma may progress to develop watery [[diarrhea]], [[abdominal pain]], [[bloating]], [[nausea]], [[vomiting]], [[skin rash]], [[backache]], [[flushing]], and [[lethargy]]. | * Patients with VIPoma may progress to develop watery [[diarrhea]], [[abdominal pain]], [[bloating]], [[nausea]], [[vomiting]], [[skin rash]], [[backache]], [[flushing]], and [[lethargy]]. | ||
* The symptoms of insulinoma are found in any age group and start with [[Insulinoma history and symptoms|neuroglycopenic symptoms]] such as [[altered mental status]], [[Visual disturbance|visual disturbances]], [[confusion]] and [[adrenergic]] symptoms such as profuse [[sweating]], [[palpitations]] and [[tremors]]. | * The symptoms of insulinoma are found in any age group and start with [[Insulinoma history and symptoms|neuroglycopenic symptoms]] such as [[altered mental status]], [[Visual disturbance|visual disturbances]], [[confusion]] and [[adrenergic]] symptoms such as profuse [[sweating]], [[palpitations]] and [[tremors]]. | ||
* Zollinger Ellison syndrome presents with refractory [[peptic ulcer disease]], severe [[gastroesophageal reflux disease]] ([[GERD]]), [[diarrhea]] and finally death, mainly due to complications of the refractory [[peptic ulcer disease]]. | * Zollinger Ellison syndrome presents with refractory [[peptic ulcer disease]], severe [[gastroesophageal reflux disease]] ([[GERD]]), [[diarrhea]], and finally death, mainly due to complications of the refractory [[peptic ulcer disease]]. | ||
* Patients with [[glucagonoma]] may progress to develop [[necrolytic migratory erythema]], [[cheilosis]], [[stomatitis]], [[diarrhea]], [[polyuria]], and [[polydipsia]]. | * Patients with [[glucagonoma]] may progress to develop [[necrolytic migratory erythema]], [[cheilosis]], [[stomatitis]], [[diarrhea]], [[polyuria]], and [[polydipsia]]. | ||
* Patients with [[somatostatinoma]] present with headaches, frequent urination, dry skin and mouth, or feeling hungry, thirsty, tired, or weak, diarrhea, steatorrhea and gallstones. | * Patients with [[somatostatinoma]] present with headaches, frequent urination, dry skin and mouth, or feeling hungry, thirsty, tired, or weak, diarrhea, steatorrhea and gallstones. | ||
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=== Prognosis === | === Prognosis === | ||
Prognosis of pancreatic [[islet cell]] carcinoma depends on the following<ref name="pmid18515795">{{cite journal| author=Halfdanarson TR, Rabe KG, Rubin J, Petersen GM| title=Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. | journal=Ann Oncol | year= 2008 | volume= 19 | issue= 10 | pages= 1727-33 | pmid=18515795 | doi=10.1093/annonc/mdn351 | pmc=2735065 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18515795 }} </ref> | Prognosis of pancreatic [[islet cell]] carcinoma depends on the following: <ref name="pmid18515795">{{cite journal| author=Halfdanarson TR, Rabe KG, Rubin J, Petersen GM| title=Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. | journal=Ann Oncol | year= 2008 | volume= 19 | issue= 10 | pages= 1727-33 | pmid=18515795 | doi=10.1093/annonc/mdn351 | pmc=2735065 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18515795 }} </ref> | ||
* Whether or not the [[tumor]] can be removed by [[surgery]]. | * Whether or not the [[tumor]] can be removed by [[surgery]]. | ||
* The stage of the [[tumor]], the size of the [[tumor]], whether [[cancer]] has spread outside the [[pancreas]]. | * The stage of the [[tumor]], the size of the [[tumor]], whether [[cancer]] has spread outside the [[pancreas]]. | ||
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=== Diagnostic findings === | === Diagnostic findings === | ||
* The dynamic spiral [[Computed tomography|CT scan]] with contrast media(oral and IV) enhancement is the gold standard test for the [[diagnosis]] and [[Cancer staging|staging]] of [[pancreatic cancer]]<ref name="pmid17438169">{{cite journal| author=Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP et al.| title=Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. | journal=Arch Surg | year= 2007 | volume= 142 | issue= 4 | pages= 347-54 | pmid=17438169 | doi=10.1001/archsurg.142.4.347 | pmc=3979851 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17438169 }} </ref><ref name="pmid19129613">{{cite journal| author=Horwhat JD, Gerke H, Acosta RD, Pavey DA, Jowell PS| title=Focal or diffuse "fullness" of the pancreas on CT. Usually benign, but EUS plus/minus FNA is warranted to identify malignancy. | journal=JOP | year= 2009 | volume= 10 | issue= 1 | pages= 37-42 | pmid=19129613 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19129613 }} </ref> | * The dynamic spiral [[Computed tomography|CT scan]] with contrast media (oral and IV) enhancement is the gold standard test for the [[diagnosis]] and [[Cancer staging|staging]] of [[pancreatic cancer]]. <ref name="pmid17438169">{{cite journal| author=Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP et al.| title=Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. | journal=Arch Surg | year= 2007 | volume= 142 | issue= 4 | pages= 347-54 | pmid=17438169 | doi=10.1001/archsurg.142.4.347 | pmc=3979851 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17438169 }} </ref><ref name="pmid19129613">{{cite journal| author=Horwhat JD, Gerke H, Acosta RD, Pavey DA, Jowell PS| title=Focal or diffuse "fullness" of the pancreas on CT. Usually benign, but EUS plus/minus FNA is warranted to identify malignancy. | journal=JOP | year= 2009 | volume= 10 | issue= 1 | pages= 37-42 | pmid=19129613 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19129613 }} </ref> | ||
** [[Morphology|Morphological]] changes of the [[gland]] | ** [[Morphology|Morphological]] changes of the [[gland]] | ||
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** [[Pancreatic duct|Pancreatic ductal]] [[Dilation|dilatation]] | ** [[Pancreatic duct|Pancreatic ductal]] [[Dilation|dilatation]] | ||
** [[Pancreas|Pancreatic]] atrophy | ** [[Pancreas|Pancreatic]] atrophy | ||
** [[Obstruction]] of the [[ | ** [[Obstruction]] of the [[common bile duct]] ([[CBD]]) | ||
* Measuring hormone levels for specific tumor. | * Measuring hormone levels for specific tumor. | ||
=== History and symptoms === | === History and symptoms === | ||
History includes<ref name="pmid20087335">{{cite journal| author=Zerbi A, Falconi M, Rindi G, Delle Fave G, Tomassetti P, Pasquali C et al.| title=Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic cases. | journal=Am J Gastroenterol | year= 2010 | volume= 105 | issue= 6 | pages= 1421-9 | pmid=20087335 | doi=10.1038/ajg.2009.747 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20087335 }} </ref><ref name="pmid17312380">{{cite journal| author=Falconi M, Plockinger U, Kwekkeboom DJ, Manfredi R, Korner M, Kvols L et al.| title=Well-differentiated pancreatic nonfunctioning tumors/carcinoma. | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 196-211 | pmid=17312380 | doi=10.1159/000098012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312380 }} </ref><ref name="pmid15522652">{{cite journal| author=Khorana AA, Fine RL| title=Pancreatic cancer and thromboembolic disease. | journal=Lancet Oncol | year= 2004 | volume= 5 | issue= 11 | pages= 655-63 | pmid=15522652 | doi=10.1016/S1470-2045(04)01606-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15522652 }} </ref> | History includes: <ref name="pmid20087335">{{cite journal| author=Zerbi A, Falconi M, Rindi G, Delle Fave G, Tomassetti P, Pasquali C et al.| title=Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic cases. | journal=Am J Gastroenterol | year= 2010 | volume= 105 | issue= 6 | pages= 1421-9 | pmid=20087335 | doi=10.1038/ajg.2009.747 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20087335 }} </ref><ref name="pmid17312380">{{cite journal| author=Falconi M, Plockinger U, Kwekkeboom DJ, Manfredi R, Korner M, Kvols L et al.| title=Well-differentiated pancreatic nonfunctioning tumors/carcinoma. | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 196-211 | pmid=17312380 | doi=10.1159/000098012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312380 }} </ref><ref name="pmid15522652">{{cite journal| author=Khorana AA, Fine RL| title=Pancreatic cancer and thromboembolic disease. | journal=Lancet Oncol | year= 2004 | volume= 5 | issue= 11 | pages= 655-63 | pmid=15522652 | doi=10.1016/S1470-2045(04)01606-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15522652 }} </ref> | ||
* episodes of [[altered mental status]]/[[confusion]] | * episodes of [[altered mental status]]/[[confusion]] | ||
* [[Visual]] disturbances | * [[Visual]] disturbances | ||
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==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
==== Chemotherapy: <ref name="pmid22996141">{{cite journal| author=Tas F, Sen F, Odabas H, Kılıc L, Keskın S, Yıldız I| title=Performance status of patients is the major prognostic factor at all stages of pancreatic cancer. | journal=Int J Clin Oncol | year= 2013 | volume= 18 | issue= 5 | pages= 839-46 | pmid=22996141 | doi=10.1007/s10147-012-0474-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22996141 }} </ref><ref name="pmid19307501">{{cite journal| author=Huguet F, Girard N, Guerche CS, Hennequin C, Mornex F, Azria D| title=Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review. | journal=J Clin Oncol | year= 2009 | volume= 27 | issue= 13 | pages= 2269-77 | pmid=19307501 | doi=10.1200/JCO.2008.19.7921 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19307501 }} </ref><ref name="pmid17986845">{{cite journal| author=Brasiūniene B, Juozaityte E| title=The effect of combined treatment methods on survival and toxicity in patients with pancreatic cancer. | journal=Medicina (Kaunas) | year= 2007 | volume= 43 | issue= 9 | pages= 716-25 | pmid=17986845 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17986845 }} </ref> ==== | |||
* [[Paclitaxel]] | |||
* [[Gemcitabine]] | |||
* [[Erlotinib]] | |||
* [[Streptozocin]] | |||
* [[Doxorubicin hydrochloride|Doxorubicin]] | |||
==== Symptomatic treatment ==== | |||
* [[Octreotide]] | |||
* [[Hepatic artery]] [[embolization]] | * [[Hepatic artery]] [[embolization]] | ||
* [[Radiation therapy|Radiation]] | * [[Radiation therapy|Radiation]] | ||
| Line 263: | Line 265: | ||
===Surgery=== | ===Surgery=== | ||
* The different surgical techniques that may be used for resectable [[pancreatic cancer]] include [[pancreaticoduodenectomy]] (Whipple Procedure), pylorus sparing [[Pancreaticoduodenectomy|Whipple procedure]], distal [[pancreatectomy]] and total [[pancreatectomy]]<ref name="pmid1493387">{{cite journal| author=Bancroft J| title=Sexual behaviour in Britain and France. | journal=BMJ | year= 1992 | volume= 305 | issue= 6867 | pages= 1447-8 | pmid=1493387 | doi= | pmc=1884127 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1493387 }} </ref> | * The different surgical techniques that may be used for resectable [[pancreatic cancer]] include [[pancreaticoduodenectomy]] (Whipple Procedure), pylorus sparing [[Pancreaticoduodenectomy|Whipple procedure]], distal [[pancreatectomy]] and total [[pancreatectomy]]. <ref name="pmid1493387">{{cite journal| author=Bancroft J| title=Sexual behaviour in Britain and France. | journal=BMJ | year= 1992 | volume= 305 | issue= 6867 | pages= 1447-8 | pmid=1493387 | doi= | pmc=1884127 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1493387 }} </ref> | ||
* The method of [[Resection|surgical resection]]<nowiki/>depends on the locally invasive characteristics and [[Size consistency|size]] of the [[neoplasm]]. | *<nowiki/>The method of [[Resection|surgical resection]]<nowiki/>depends on the locally invasive characteristics and [[Size consistency|size]] of the [[neoplasm]]. | ||
* Minimal [[invasive]] surgery such as [[laparoscopic surgery]] is preferred especially for small tumors. | * Minimal [[invasive]] surgery such as<nowiki/> [[laparoscopic surgery]] is preferred especially for small tumors. | ||
==References== | ==References== | ||
Latest revision as of 14:37, 9 April 2019
| Pancreatic islet cell carcinoma |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]
Synonyms and keywords:Islet cell carcinoma of pancreas, Pancreatic islet cell cancer
Overview
Pancreas has 2 types of cells, acinar and islet that produce exocrine and endocrine hormones respectively. The pancreatic islet cell carcinomas are also known as neuroendocrine tumors. They are of 6 types depending on the type of hormone the tumor produces. They can occur sporadically or in association with other disorders such as multiple endocrine neoplasia type 1, Von Hippel Lindau disease, neurofibromatosis type 1 and tuberous sclerosis which are inherited in an autosomal dominant pattern. The most common metastatic sites are the liver, the lymph nodes, and the bones. The cancer usually presents with jaundice, light-colored stools, dark urine, and pain in the upper or middle abdomen and back, unexplained weight loss, anorexia, fatigue and symptoms according to the hormone produced. The treatment depends on the spread of the cancer and includes both medical and surgical treatment.
Historical perspective
In 1869, pancreatic islet cells were discovered by Paul Langerhans and the first adenoma of islets was discovered by Nicholls in 1902[1].
Classification
Pancreatic islet cell carcinoma is of 6 types: [2]
- Glucagonoma
- Non functional islet cell tumor
Pathophysiology
- Acinar cells and Islet cells are the 2 types of cells in pancreas[3].
- Acinar cells are responsible for secretion of enzymes and bicarbonate involved in the digestion process.
- Islet cells of pancreas play the endocrine organ role, by producing hormones such as insulin, gastrin, glucagon, somatostatin, and vasoactive intestinal polypeptide.
- The pancreatic islet cell carcinomas are also known as neuroendocrine tumors[4].
- They can occur sporadically or in association with other disorders such as multiple endocrine neoplasia type 1, Von Hippel Lindau disease, neurofibromatosis type 1 and tuberous sclerosis which are inherited in an autosomal dominant pattern.
- Islet cell carcinoma is divided into 6 types depending on the type of hormone produced.
- These tumors produce excessive amounts of hormones and cause symptoms similar to the hormones' action.
- Insulinoma - hypoglycemia due to decreased glucose synthesis in liver[5].
- Gastrinoma - Zollinger-Ellison syndrome, in which hypersecretion of gastrin causes hydrochloric acid release which causes peptic ulcers.
- Glucagonoma - hyperglucagonemia, zinc deficiency, fatty acid deficiency, hypoaminoacidemia that may cause necrolytic migratory erythema[6].
- VIPoma - Elevated serum VIP levels leads to increased intracellular cAMP which causes increased intestinal secretion of water along with Na+, K+, HCO3 -, and Cl- in the intestinal lumen, causing diarrhea and hypokalemia.
- Somatostatinoma - increased release of somatostatin causes gallstones, diarrhea and fat malabsorption resulting in steatorrhea.
- Non functional islet cell tumor- These do not produce any hormones, symptoms depend on the size and metastasis. [7]
- The tumor cells are usually round with regular bland nuclei which produce large number of secretory granules with diffuse immunoexpression of neuroendocrinemarkers.
- The poorly differentiated neuroendocrine tumor (NET) shows an atypical, sheet-like, diffuse and irregular nuclei, less cytoplasmic secretory granules, and limited biomarker immunoexpression.
- Head of the pancreas is most commonly involved (75% of cases) followed by the tail.
- The most common metastatic sites are the liver, the lymph nodes, and the bones.
- Pancreatic islet cell carcinoma is divided into 3 grades by WHO.[8]
2010 WHO grading system for pNETs
| Grade 1 (G1) | Grade 2 (G2) | Grade 3 (G3) | |
|---|---|---|---|
| Ki-67 index | <3% | 3-20% | >20% |
| Mitotic count | <2/10 HPF | 2-20/10 HPF | >20/10 HPF |
| Differentiation | Well differentiated | Well differentiated | Poorly differentiated |
| 5-year survival rate | 85% | 78% | 9% |
Causes
There are no established causes of pancreatic islet cell carcinoma but there is an association with MEN 1 syndrome and rarely with Von Hippel-Lindau disease, Neurofibromatosis-1 and Tuberous sclerosis[9].
Epidemiology and Demographics
- The incidence of pancreatic islet cell carcinoma is 1 in 100000 people[10].
Age
- It mostly occurs in fourth to sixth decades of life.
Gender
- Its incidence is equal in both males and females.
Race
- Race has no effect on the incidence.
Staging
Pancreatic cancer is staged according to the TNM staging system based on the primary tumor, lymph nodes involved and distant metastasis.[11][12]
| TNM Classification for Pancreatic Cancer: | |
|---|---|
| Primary tumor | |
| TX | Primary tumor cannot be assessed |
| T0 | No evidence of primary tumor |
| Tis | Carcinoma in situ |
| T1 | Tumor limited to the pancreas, ≤2 cm in greatest dimension |
| T2 | Tumor limited to the pancreas, >2 cm in greatest dimension |
| T3 | Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery |
| T4 | Tumor involves the celiac axis or the superior mesenteric artery (unresectable primary tumor) |
| Regional lymph nodes | |
| NX | Regional lymph nodes cannot be assessed |
| N0 | No regional lymph node metastasis |
| N1 | Regional lymph node metastasis |
| Distant metastases | |
| MX | Distant metastasis cannot be assessed |
| M0 | No distant metastasis |
| M1 | Distant metastasis |
Screening
Screening for pancreatic islet cell carcinoma is not done.
Natural history, complications and prognosis
Natural history
- The cancer usually presents with jaundice, light-colored stools, dark urine, pain in the upper or middle abdomen and back, unexplained weight loss, anorexia, fatigue and symptoms according to the hormone produced.[13][14][15]
- Patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.
- The symptoms of insulinoma are found in any age group and start with neuroglycopenic symptoms such as altered mental status, visual disturbances, confusion and adrenergic symptoms such as profuse sweating, palpitations and tremors.
- Zollinger Ellison syndrome presents with refractory peptic ulcer disease, severe gastroesophageal reflux disease (GERD), diarrhea, and finally death, mainly due to complications of the refractory peptic ulcer disease.
- Patients with glucagonoma may progress to develop necrolytic migratory erythema, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia.
- Patients with somatostatinoma present with headaches, frequent urination, dry skin and mouth, or feeling hungry, thirsty, tired, or weak, diarrhea, steatorrhea and gallstones.
- If left untreated, patients may progress to develop exocrine pancreatic insufficiency arising from pancreatic duct obstruction leading to malabsorption, malnutrition and cachexia. Dudodenal obstruction and biliary obstruction may cause symptoms of bowel obstruction and jaundice.
- Metastasis may occur to different sites.
Complications
- Hematemesis
- Anemia
- Duodenal ulcer perforation
- Weight loss
- Seizures
- Coma
- Neuropsychiatric manifestations include depression, dementia, psychosis, and agitation
- Dilated cardiomyopathy
- Cardiac arrest from low blood potassium level
- Dehydration
- Obstructive jaundice can present with features of cholangitis:
- Duodenal obstruction
Prognosis
Prognosis of pancreatic islet cell carcinoma depends on the following: [16]
- Whether or not the tumor can be removed by surgery.
- The stage of the tumor, the size of the tumor, whether cancer has spread outside the pancreas.
- The patient’s general health.
- Whether the tumor has just been diagnosed or has recurred.
- The presence of metastasis is associated with a particularly poor prognosis. Grade 1 and 2 tumor have the most favorable prognosis.
- The 10-year event free survival rate is less than 51.6% with metastasis and 64.3% without metastasis.
Diagnosis
Diagnostic findings
- The dynamic spiral CT scan with contrast media (oral and IV) enhancement is the gold standard test for the diagnosis and staging of pancreatic cancer. [17][18]
- Morphological changes of the gland
- Destruction of the peripancreatic fat and loss of the sharp margins with surrounding structures
- Involvement of the regional lymph nodes and adjacent vasculature
- Pancreatic ductal dilatation
- Pancreatic atrophy
- Obstruction of the common bile duct (CBD)
- Measuring hormone levels for specific tumor.
History and symptoms
- episodes of altered mental status/confusion
- Visual disturbances
- Sweating
- Negative history for exogenous insulin or oral hypoglycemic agents such as Sulfonylureas
- Palpitations
- Seizures
- Tremors
- Behavioral disturbances
- Weakness
- Abdominal pain
- Weight loss
- Loss of appetite
- Diarrhea
- Heart burn
- Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
- Polyuria
- Polydypsia
- Weight loss
- Numbness caused due to hypokalaemia
- Flushing
Physical examination
- Jaundice
- Excoriations of the skin from unrelenting pruritus
- Pallor ±
- Migratory superficial thrombophlebitis (classic Trousseau's syndrome)
- Abdominal distension
- Abdominal tenderness
- Hepatomegaly
- Splenomegaly
- Fluid thrill and percussion depending on ascites
- Erythematous, ring shaped rash that blisters, erodes, and crusts over suggesting necrolytic migratory erythema.
- Ophthalmoscopic exam may be abnormal with findings of cotton wool spots, flame hemorrhage, and dot and blot hemorrhage
- Muscle atrophy may be present
- Altered mental status in insulinoma
- Tremors
Treatment
Medical Therapy
Chemotherapy: [20][21][22]
Symptomatic treatment
- Octreotide
- Hepatic artery embolization
- Radiation
- Percutaneous ethanol injection/ Ethanol ablation
- Radiofrequency ablation (RFA)
- Cryoablation
Surgery
- The different surgical techniques that may be used for resectable pancreatic cancer include pancreaticoduodenectomy (Whipple Procedure), pylorus sparing Whipple procedure, distal pancreatectomy and total pancreatectomy. [23]
- The method of surgical resectiondepends on the locally invasive characteristics and size of the neoplasm.
- Minimal invasive surgery such as laparoscopic surgery is preferred especially for small tumors.
References
- ↑ Stamatakos M, Safioleas C, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M (2009). "Insulinoma: a rare neuroendocrine pancreatic tumor". Chirurgia (Bucur). 104 (6): 669–73. PMID 20187464.
- ↑ Klöppel G, Perren A, Heitz PU (2004). "The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification". Ann N Y Acad Sci. 1014: 13–27. PMID 15153416.
- ↑ Metz DC, Jensen RT (2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.
- ↑ 4.0 4.1 Falconi M, Plockinger U, Kwekkeboom DJ, Manfredi R, Korner M, Kvols L; et al. (2006). "Well-differentiated pancreatic nonfunctioning tumors/carcinoma". Neuroendocrinology. 84 (3): 196–211. doi:10.1159/000098012. PMID 17312380.
- ↑ Service FJ, McMahon MM, O'Brien PC, Ballard DJ (1991). "Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study". Mayo Clin Proc. 66 (7): 711–9. PMID 1677058.
- ↑ Frankton S, Bloom SR (1996). "Gastrointestinal endocrine tumours. Glucagonomas". Baillieres Clin Gastroenterol. 10 (4): 697–705. PMID 9113318.
- ↑ Madura JA, Cummings OW, Wiebke EA, Broadie TA, Goulet RL, Howard TJ (1997). "Nonfunctioning islet cell tumors of the pancreas: a difficult diagnosis but one worth the effort". Am Surg. 63 (7): 573–7, discussion 577-8. PMID 9202529.
- ↑ Bond-Smith G, Banga N, Hammond TM, Imber CJ (2012). "Pancreatic adenocarcinoma". BMJ. 344: e2476. doi:10.1136/bmj.e2476. PMID 22592847.
- ↑ Leoncini E, Carioli G, La Vecchia C, Boccia S, Rindi G (2016). "Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis". Ann Oncol. 27 (1): 68–81. doi:10.1093/annonc/mdv505. PMID 26487581.
- ↑ Hallet J, Law CH, Cukier M, Saskin R, Liu N, Singh S (2015). "Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes". Cancer. 121 (4): 589–97. doi:10.1002/cncr.29099. PMID 25312765.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S (2010). "The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems". Pancreas. 39 (6): 707–12. doi:10.1097/MPA.0b013e3181ec124e. PMID 20664470.
- ↑ Graves TD, Gandhi S, Smith SJ, Sisodiya SM, Conway GS (2004). "Misdiagnosis of seizures: insulinoma presenting as adult-onset seizure disorder". J Neurol Neurosurg Psychiatry. 75 (8): 1091–2. doi:10.1136/jnnp.2003.029249. PMC 1739168. PMID 15258206.
- ↑ de Mestier L, Hentic O, Cros J, Walter T, Roquin G, Brixi H; et al. (2015). "Metachronous hormonal syndromes in patients with pancreatic neuroendocrine tumors: a case-series study". Ann Intern Med. 162 (10): 682–9. doi:10.7326/M14-2132. PMID 25984844.
- ↑ 15.0 15.1 Zerbi A, Falconi M, Rindi G, Delle Fave G, Tomassetti P, Pasquali C; et al. (2010). "Clinicopathological features of pancreatic endocrine tumors: a prospective multicenter study in Italy of 297 sporadic cases". Am J Gastroenterol. 105 (6): 1421–9. doi:10.1038/ajg.2009.747. PMID 20087335.
- ↑ Halfdanarson TR, Rabe KG, Rubin J, Petersen GM (2008). "Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival". Ann Oncol. 19 (10): 1727–33. doi:10.1093/annonc/mdn351. PMC 2735065. PMID 18515795.
- ↑ Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP; et al. (2007). "Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005". Arch Surg. 142 (4): 347–54. doi:10.1001/archsurg.142.4.347. PMC 3979851. PMID 17438169.
- ↑ Horwhat JD, Gerke H, Acosta RD, Pavey DA, Jowell PS (2009). "Focal or diffuse "fullness" of the pancreas on CT. Usually benign, but EUS plus/minus FNA is warranted to identify malignancy". JOP. 10 (1): 37–42. PMID 19129613.
- ↑ Khorana AA, Fine RL (2004). "Pancreatic cancer and thromboembolic disease". Lancet Oncol. 5 (11): 655–63. doi:10.1016/S1470-2045(04)01606-7. PMID 15522652.
- ↑ Tas F, Sen F, Odabas H, Kılıc L, Keskın S, Yıldız I (2013). "Performance status of patients is the major prognostic factor at all stages of pancreatic cancer". Int J Clin Oncol. 18 (5): 839–46. doi:10.1007/s10147-012-0474-9. PMID 22996141.
- ↑ Huguet F, Girard N, Guerche CS, Hennequin C, Mornex F, Azria D (2009). "Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review". J Clin Oncol. 27 (13): 2269–77. doi:10.1200/JCO.2008.19.7921. PMID 19307501.
- ↑ Brasiūniene B, Juozaityte E (2007). "The effect of combined treatment methods on survival and toxicity in patients with pancreatic cancer". Medicina (Kaunas). 43 (9): 716–25. PMID 17986845.
- ↑ Bancroft J (1992). "Sexual behaviour in Britain and France". BMJ. 305 (6867): 1447–8. PMC 1884127. PMID 1493387 Check
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