Necrolytic migratory erythema

Jump to navigation Jump to search

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Necrolytic migratory erythema

WikiDoc Resources for Necrolytic migratory erythema

Articles

Most recent articles on Necrolytic migratory erythema

Most cited articles on Necrolytic migratory erythema

Review articles on Necrolytic migratory erythema

Articles on Necrolytic migratory erythema in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Necrolytic migratory erythema

Images of Necrolytic migratory erythema

Photos of Necrolytic migratory erythema

Podcasts & MP3s on Necrolytic migratory erythema

Videos on Necrolytic migratory erythema

Evidence Based Medicine

Cochrane Collaboration on Necrolytic migratory erythema

Bandolier on Necrolytic migratory erythema

TRIP on Necrolytic migratory erythema

Clinical Trials

Ongoing Trials on Necrolytic migratory erythema at Clinical Trials.gov

Trial results on Necrolytic migratory erythema

Clinical Trials on Necrolytic migratory erythema at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Necrolytic migratory erythema

NICE Guidance on Necrolytic migratory erythema

NHS PRODIGY Guidance

FDA on Necrolytic migratory erythema

CDC on Necrolytic migratory erythema

Books

Books on Necrolytic migratory erythema

News

Necrolytic migratory erythema in the news

Be alerted to news on Necrolytic migratory erythema

News trends on Necrolytic migratory erythema

Commentary

Blogs on Necrolytic migratory erythema

Definitions

Definitions of Necrolytic migratory erythema

Patient Resources / Community

Patient resources on Necrolytic migratory erythema

Discussion groups on Necrolytic migratory erythema

Patient Handouts on Necrolytic migratory erythema

Directions to Hospitals Treating Necrolytic migratory erythema

Risk calculators and risk factors for Necrolytic migratory erythema

Healthcare Provider Resources

Symptoms of Necrolytic migratory erythema

Causes & Risk Factors for Necrolytic migratory erythema

Diagnostic studies for Necrolytic migratory erythema

Treatment of Necrolytic migratory erythema

Continuing Medical Education (CME)

CME Programs on Necrolytic migratory erythema

International

Necrolytic migratory erythema en Espanol

Necrolytic migratory erythema en Francais

Business

Necrolytic migratory erythema in the Marketplace

Patents on Necrolytic migratory erythema

Experimental / Informatics

List of terms related to Necrolytic migratory erythema

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Huda A. Karman, M.D.

Overview

Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.

Diagnosis

Symptoms

It consists of serpiginous (slow progressing) erythematous plaques. Where the migratory edge has an "eroded" appearance. It usually starts in the Perineum.

Associated symptoms

Weight loss, anemia , mild diabetes, diarrhea and glossitis are associated. Liver metastasis is often present.

Differentiating necrolytic migratory erythema from Other Diseases

Disease Erythema Characteristics Signs and Symptoms Associated Conditions Histopathology Lab finding

& Other evaluation

Prognosis
Necrolytic migratory erythema (NME)
  • Due to the difficulty of necrolytic migratory erythema recognition, and its association with glucagonoma, diagnosis is usually delayed
  • Necrolytic migratory erythema usually resolved after the resection and treatment of the pancreatic tumor, eg.10 days after tumor resection
  • Early recognition is crucial for better diagnosis and prognosis
Erythema annulare centrifugum (EAC) [1]
  • Migratory annular and configurate erythematous

or polycyclic lesions

  • Eruption migrate at a slower rate (2 -3 mm/d) reaching up to 10 cm in diameter with central clearing
  • Cover only a small percentage of the total body surface   
  • Annular or polycyclic lesions which may begin as urticaria-like papule
  • Eventually old lesions can spontaneously resolve in several days to a few weeks while new eruptions develop.
  • The deep form of erythema annulare centrifugum has a firm, indurated border, is rarely pruritic, and has no scale
  • The superficial type of erythema annulare centrifugum has an indistinct scaly border and is usually pruritic  
  • No specific laboratory changes
  • Lesions disappear after the underlying etiology is managed (allergy, infection, malignancy)
  • if no underlying cause, lesions can recur after discontinuation of the supportive treatment
Erythema gyratum repens (EGR)
  • Migratory annular and configurate erythematous bands that form concentric rings
  • Wood grain scaly appearance
  • scales follows the leading edge of the bands
  • Eruption migrates more rapidly, 1cm/d

(Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia)

  • Skin manifestations can be improved within 48 hours of the resection of the underlying tumor with on of the following:
    • Complete cure of the skin eruption and pruritus
    • Temporary improvement then recurrence of the eruption (specially in cases of metastasis)
    • No effect of the tumor treatment on the course of EGR
      • Death can occur few weeks after the detection of the malignancy, few months, or four years as in Gammel's patient.



References


Template:Skin and subcutaneous tissue symptoms and signs Template:Nervous and musculoskeletal system symptoms and signs Template:Urinary system symptoms and signs Template:Cognition, perception, emotional state and behaviour symptoms and signs Template:Speech and voice symptoms and signs Template:General symptoms and signs


Template:WikiDoc Sources