Necrolytic migratory erythema
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Necrolytic migratory erythema |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Huda A. Karman, M.D.
Overview
Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
Diagnosis
Symptoms
It consists of serpiginous (slow progressing) erythematous plaques. Where the migratory edge has an "eroded" appearance. It usually starts in the Perineum.
- Associated symptoms
Weight loss, anemia , mild diabetes, diarrhea and glossitis are associated. Liver metastasis is often present.
Differentiating necrolytic migratory erythema from Other Diseases
- Necrolytic migratory erythema has to be differentiated from Reactive gyrate erythematous eruptions, such as:
- Erythema annulare centrifugum (EAC)
- Erythema gyratum repens (EGR)
- Reactive (figurate or gyrate) erythemas that are associated with malignancy include:[1][2]
Disease | Erythema Characteristics | Signs and Symptoms | Associated Conditions | Histopathology | Lab finding
& Other evaluation |
Prognosis |
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Necrolytic migratory erythema (NME) |
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Erythema annulare centrifugum (EAC) [1] |
or polycyclic lesions
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Erythema gyratum repens (EGR) |
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(Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia) |
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References
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