'''Oxprenolol''' ('''Trasacor''', '''Trasicor''', '''Coretal''', '''Laracor''', '''Slow-Pren''', '''Captol''', '''Corbeton''', '''Slow-Trasicor''', '''Tevacor''', '''Trasitensin''', '''Trasidex''') is a non-selective [[beta blocker]] with some intrinsic [[sympathomimetic amine|sympathomimetic]] activity. It is used for the treatment of [[angina pectoris]], abnormal [[heart]] rhythms and [[arterial hypertension|high blood pressure]].
==Overview==
Oxprenolol is a [[lipophilic]] beta blocker which passes the [[blood–brain barrier]] more easily than water soluble beta blockers. As such, it is associated with a higher incidence of [[Central nervous system|CNS]]-related side effects than hydrophilic ligands such as [[atenolol]], [[sotalol]] and [[nadolol]].<ref>{{cite journal |author=McDevitt DG |title=Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs |series=8 |journal=Eur. Heart J. |volume=Suppl M |issue= |pages=9–14 |year=1987 |pmid=2897304 |doi=10.1093/eurheartj/8.suppl_M.9}}</ref>
'''Oxprenolol''' is a non-selective [[beta blocker]] with some intrinsic [[sympathomimetic amine|sympathomimetic]] activity. It is used for the treatment of [[angina pectoris]] and abnormal [[heart]] rhythms. It is also used for treating [[arterial hypertension|high blood pressure]].
Oxprenolol is a [[lipophilic]] beta blocker which passes the [[blood-brain barrier]] more easily than water soluble beta blockers. As such, it is associated with a higher incidence of [[CNS]]-related side effects than hydrophilic ligands such as [[atenolol]], [[sotalol]] and [[nadolol]].<ref>{{cite journal |author=McDevitt DG |title=Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs |journal=Eur. Heart J. |volume=8 Suppl M |issue= |pages=9-14 |year=1987 |pmid=2897304 |doi=}}</ref>
Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation.<ref>{{cite journal | doi = 10.1136/thx.35.2.160 | journal = Thorax | year = 1980 | volume = 35 | pmc = 471246 | issue = 2 | pages = 160 | title = Severe asthma after inadvertent ingestion of oxprenolol | author = I P Williams and F J Millard | pmid = 7376124}}</ref>
Oxprenolol is an potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.
== Stereochemistry ==
==References==
{{Reflist}}
{{beta blockers}}
Oxprenolol is a chiral compound, the beta blocker is used as a [[racemate]], e. g. a 1:1 mixture of (''R'')-(+)-oxprenolol and (''S'')-(–)-oxprenolol. Analytical methods ([[HPLC]]) for the separation and quantification of (''R'')-(+)-oxprenolol and (''S'')-(–)-oxprenolol in urine and in pharmaceutical formulations have been described in the literature. <ref name=Abounassif>{{cite journal | doi = 10.1007/s00706-011-0605-4 | title = Separation and quantitation of oxprenolol in urine and pharmaceutical formulations by HPLC using a Chiralpak IC and UV detection | year = 2011 | last1 = Abounassif | first1 = Mohammed A. | last2 = Hefnawy | first2 = Mohammed M. | last3 = Mostafa | first3 = Gamal A. E. | journal = Monatshefte für Chemie - Chemical Monthly | volume = 143 | issue = 3 | pages = 365}}</ref>
:[[File:(±)-Oxoprenolol Structural Formulae V.2.svg|thumb|left|(''R'')-(+)-Oxprenolol (top) and (''S'')-(–)-oxprenolol]]{{clear-left}}
Oxprenolol (Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure.
Oxprenolol is a lipophilic beta blocker which passes the blood–brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]
Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation.[2]
Stereochemistry
Oxprenolol is a chiral compound, the beta blocker is used as a racemate, e. g. a 1:1 mixture of (R)-(+)-oxprenolol and (S)-(–)-oxprenolol. Analytical methods (HPLC) for the separation and quantification of (R)-(+)-oxprenolol and (S)-(–)-oxprenolol in urine and in pharmaceutical formulations have been described in the literature. [3]
↑Abounassif, Mohammed A.; Hefnawy, Mohammed M.; Mostafa, Gamal A. E. (2011). "Separation and quantitation of oxprenolol in urine and pharmaceutical formulations by HPLC using a Chiralpak IC and UV detection". Monatshefte für Chemie - Chemical Monthly. 143 (3): 365. doi:10.1007/s00706-011-0605-4.
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