Nilotinib: Difference between revisions
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Revision as of 14:19, 20 August 2012
| File:Nilotinib.svg | |
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| Routes of administration | Oral |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C28H22F3N7O |
| Molar mass | 529.516 g/mol |
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WikiDoc Resources for Nilotinib |
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Most recent articles on Nilotinib |
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Clinical Trials |
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Ongoing Trials on Nilotinib at Clinical Trials.gov Clinical Trials on Nilotinib at Google
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US National Guidelines Clearinghouse on Nilotinib
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Patient resources on Nilotinib Discussion groups on Nilotinib Directions to Hospitals Treating Nilotinib Risk calculators and risk factors for Nilotinib
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Causes & Risk Factors for Nilotinib |
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Overview
Nilotinib, in the form of the hydrochloride monohydrate salt, is a tyrosine kinase inhibitor approved as Tasigna® in the USA and the EU for drug-resistant chronic myelogenous leukemia (CML)[1]. In June 2006, a Phase I clinical trial found nilotinib, also known by its clinical code AMN107, has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec®), another tyrosine kinase inhibitor currently used as a first-line treatment.[2] In that study 92% of patients (already resistant or unresponsive to Gleevec) achieved a normal white blood cell counts after 5 month of treatment. [3]
The drug will carry a black box warning for possible heart complications. [4]
References
- ↑ Novartis 29/10/2007 Press Release.
- ↑ Kantarjian H; et al. (2006). "Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL". N Engl J Med. 354 (24): 2542–51. PMID 16775235.
- ↑ http://cws.huginonline.com/N/134323/PR/200606/1056533_5.html Patients with treatment-resistant leukemia achieve high responses to Tasigna® (nilotinib) in first published clinical trial results - Novartis 14/06/2006 Press Release.
- ↑ http://www.fda.gov/bbs/topics/NEWS/2007/NEW01734.html FDA Approves Tasigna for Treatment of Philadelphia Chromosome Positive Chronic Myeloid Leukemia - FDA 31/10/2007 Press Release
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- Chemotherapeutic agents
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- Tyrosine kinase inhibitors