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| '''Drug Side Effect'''
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|bgcolor="Beige"| [[Altretamine]], [[Amoxicillin]], [[Azacitidine]],[[Capreomycin sulfate]], [[Cefotaxime sodium]],  [[Cefaclor]], [[Cefpodoxime]], [[Ceftazidime]], [[Certolizumab pegol]], [[Chlorpropamide]], [[Cisplatin]], [[Clobazam]], [[Cyclophosphamide]], [[Cytarabine]], [[Dacarbazine]], [[Dactinomycin]],[[Dexrazoxane]], [[Docetaxel]], [[Doxorubicin Hydrochloride]], [[Epirubicin hydrochloride]], [[Ethosuximide]], [[foscarnet sodium]], [[Gemifloxacin mesylate]], [[Rifampin]], [[Febuxostat]], [[Felbamate]], [[Flavoxate]], [[Flurazepam hydrochloride]], [[Flurbiprofen]], [[Fulvestrant]], [[Hydroxychloroquine]], [[Ifosfamide]], [[Irinotecan hydrochloride]], [[Lenalidomide]], [[Lincomycin Hydrochloride]], [[Lorcaserin]], [[lomustine]], [[Loxapine]], [[Megestrol]], [[Mercaptopurine]], [[Meropenem]], [[Metaxalone]], [[Methocarbamol]], [[Milnacipran hydrochloride]], [[Mycophenolate]], [[Nabilone]], [[Nilutamide]], [[Nitisinone]], [[Olaparib]], [[Olanzapine]], [[Olsalazine]], [[Oxaprozin]], [[Oxcarbazepine]], [[Oxazepam]], [[Paclitaxel]], [[Palbociclib]], [[Penicillamine]], [[Pergolide]], [[Perphenazine]], [[Pertuzumab]], [[Pramipexole]], [[Primaquine phosphate]], [[Probenecid]], [[Promethazine]], [[Pyrimethamine]], [[Rabeprazole]], [[Radium chloride]], [[Repaglinide]], [[Romidepsin]], [[Rufinamide]], [[Sulindac]], [[Spironolactone]], [[Streptozocin]], [[Tamoxifen]], [[Teniposide]], [[Thiothixene]], [[Tiagabine]], [[Trimethadione]], [[Tolbutamide]], [[Tolazamide]], [[Toremifene]], [[Valganciclovir hydrochloride]], [[Vinblastine]], [[Zonisamide]], [[Sirolimus]]
|bgcolor="Beige"| [[Altretamine]], [[Amoxicillin]], [[Azacitidine]],[[Capreomycin sulfate]], [[Cefotaxime sodium]],  [[Cefaclor]], [[Cefpodoxime]], [[Ceftazidime]], [[Certolizumab pegol]], [[Chlorpropamide]], [[Cisplatin]], [[Clobazam]], [[Cyclophosphamide]], [[Cytarabine]], [[Dacarbazine]], [[Dactinomycin]],[[Dexrazoxane]], [[Diethylpropion]], [[Docetaxel]], [[Doxorubicin Hydrochloride]], [[Epirubicin hydrochloride]], [[Ethosuximide]], [[foscarnet sodium]], [[Gemifloxacin mesylate]], [[Rifampin]], [[Febuxostat]], [[Felbamate]], [[Flavoxate]], [[Flurazepam hydrochloride]], [[Flurbiprofen]], [[Fulvestrant]], [[Hydroxychloroquine]], [[Ifosfamide]], [[Irinotecan hydrochloride]], [[Lenalidomide]], [[Lincomycin Hydrochloride]], [[Lorcaserin]], [[lomustine]], [[Loxapine]], [[Megestrol]], [[Mercaptopurine]], [[Meropenem]], [[Metaxalone]], [[Methocarbamol]], [[Milnacipran hydrochloride]], [[Mycophenolate]], [[Nabilone]], [[Nilutamide]], [[Nitisinone]], [[Olaparib]], [[Olanzapine]], [[Olsalazine]], [[Oxaprozin]], [[Oxcarbazepine]], [[Oxazepam]], [[Paclitaxel]], [[Palbociclib]], [[Penicillamine]], [[Pergolide]], [[Perphenazine]], [[Pertuzumab]], [[Pramipexole]], [[Primaquine phosphate]], [[Probenecid]], [[Promethazine]], [[Pyrimethamine]], [[Rabeprazole]], [[Radium chloride]], [[Repaglinide]], [[Romidepsin]], [[Rufinamide]], [[Sulindac]], [[Spironolactone]], [[Streptozocin]], [[Tamoxifen]], [[Teniposide]], [[Thiothixene]], [[Tiagabine]], [[Trimethadione]], [[Tolbutamide]], [[Tolazamide]], [[Toremifene]], [[Valganciclovir hydrochloride]], [[Vinblastine]], [[Zonisamide]], [[Sirolimus]]
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Revision as of 13:23, 1 April 2015

Leukopenia
ICD-10 D70
ICD-9 288.0
DiseasesDB 32396
MeSH C15.378.553.546

WikiDoc Resources for Leukopenia

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Articles on Leukopenia in N Eng J Med, Lancet, BMJ

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Symptoms of Leukopenia

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Experimental / Informatics

List of terms related to Leukopenia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Deficiency in WBC, deficiency in white blood cells, deficiency in leukocytes, low WBC, low white blood cells, low leukocytes, neutrophilic leukopenia, neutrophilic leukocytopenia, neutrophilic leucopenia, neutrophilic leucocytopenia, neutropenia, eosinophilic leukopenia, eosinophilic leukocytopenia, eosinophilic leucopenia, eosinophilic leucocytopenia, eosinophilopenia, basophilic leukopenia, basophilic leukocytopenia, basophilic leucopenia, basophilic leucocytopenia, basophilopenia, leukocytopenia, leucopenia, leukopaenia, lymphopenia, lymphocytopenia

Overview

Deficiency of absolute number of leukocytes, which may be granulocytes (neutrophils, eosinophils, basophils) or lymphocytes (T-cells, B-cells). The majority of cases of leukopenia are actually neutropenia since neutrophils constitute the majority of leukocytes. As the principal function of white cells is to combat infection, a decrease in the number of these cells can place patients at increased risk for infection. In pancytopenia, the other cell types in the blood (red blood cells and platelets) are similarly affected. Neutropenia is a decrease in the number of circulating neutrophil granulocytes, the most abundant white blood cells. The terms leukopenia and neutropenia may occasionally be used interchangeably, as the neutrophil count is the most important indicator of infection risk. However, neutropenia is more properly considered a subset of leukopenia as a whole. Low white cell counts are associated with chemotherapy, radiation therapy, leukemia (as malignant cells overwhelm the bone marrow), myelofibrosis and aplastic anemia (failure of white and red cell creation, along with poor platelet production). In addition, many common medications can cause leukopenia. Other causes of low white blood cell count include: Influenza, systemic lupus erythematosus, typhus, malaria, HIV, tuberculosis, dengue, Rickettsial infections, enlargement of the spleen, folate deficiencies and sepsis. Many other causes exist. Leukopenia can be identified with a complete blood count.

Classification

 
 
 
 
Leukopenia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granulocytopenia
Reduced number of granulocytes
 
Lymphocytopenia
(aka Lymphopenia)
Reduced absolute number of lymphocytes (T-cells or B-cells)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Neutrophilic leukopenia
(aka neutrophilic leukocytopenia, neutrophilic leucopenia, neutrophilic leucocytopenia, neutropenia)
Absolute neutrophil count < 1.5 x 109/L
 
Eosinophilic leukopenia
(aka eosinophilic leukocytopenia, eosinophilic leucopenia, eosinophilic leucocytopenia, eosinophilopenia)
Reduced absolute number of eosinophils
 
Basophilic leukopenia
(aka basophilic leukocytopenia, basophilic leucopenia, basophilic leucocytopenia, basophilopenia)
Reduced absolute number of basophils
 

Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Altretamine, Amoxicillin, Azacitidine,Capreomycin sulfate, Cefotaxime sodium, Cefaclor, Cefpodoxime, Ceftazidime, Certolizumab pegol, Chlorpropamide, Cisplatin, Clobazam, Cyclophosphamide, Cytarabine, Dacarbazine, Dactinomycin,Dexrazoxane, Diethylpropion, Docetaxel, Doxorubicin Hydrochloride, Epirubicin hydrochloride, Ethosuximide, foscarnet sodium, Gemifloxacin mesylate, Rifampin, Febuxostat, Felbamate, Flavoxate, Flurazepam hydrochloride, Flurbiprofen, Fulvestrant, Hydroxychloroquine, Ifosfamide, Irinotecan hydrochloride, Lenalidomide, Lincomycin Hydrochloride, Lorcaserin, lomustine, Loxapine, Megestrol, Mercaptopurine, Meropenem, Metaxalone, Methocarbamol, Milnacipran hydrochloride, Mycophenolate, Nabilone, Nilutamide, Nitisinone, Olaparib, Olanzapine, Olsalazine, Oxaprozin, Oxcarbazepine, Oxazepam, Paclitaxel, Palbociclib, Penicillamine, Pergolide, Perphenazine, Pertuzumab, Pramipexole, Primaquine phosphate, Probenecid, Promethazine, Pyrimethamine, Rabeprazole, Radium chloride, Repaglinide, Romidepsin, Rufinamide, Sulindac, Spironolactone, Streptozocin, Tamoxifen, Teniposide, Thiothixene, Tiagabine, Trimethadione, Tolbutamide, Tolazamide, Toremifene, Valganciclovir hydrochloride, Vinblastine, Zonisamide, Sirolimus
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

Contraindicated Medications

Leukopenia is considered an absolute contraindication to the use of the following medications:

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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