KCNJ10: Difference between revisions

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{{Infobox_gene}}
| update_page = yes
'''ATP-sensitive inward rectifier potassium channel 10''' is a [[protein]] that in humans is encoded by the ''KCNJ10'' [[gene]].<ref name="pmid9367690">{{cite journal | vauthors = Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland NG, Jenkins NA, Kurachi Y | title = Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1 | journal = Genomics | volume = 45 | issue = 3 | pages = 629–30 | date = November 1997 | pmid = 9367690 | pmc =  | doi = 10.1006/geno.1997.4957 }}</ref><ref name="pmid8995301">{{cite journal | vauthors = Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ | title = Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3) | journal = The Journal of Biological Chemistry | volume = 272 | issue = 1 | pages = 586–93 | date = January 1997 | pmid = 8995301 | pmc =  | doi = 10.1074/jbc.272.1.586 }}</ref><ref name="pmid16382105">{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 509–26 | date = December 2005 | pmid = 16382105 | pmc = | doi = 10.1124/pr.57.4.11 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3766| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 10
| HGNCid = 6256
| Symbol = KCNJ10
| AltSymbols =; BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1
| OMIM = 602208
| ECnumber = 
| Homologene = 1689
| MGIid = 1194504
| GeneAtlas_image1 = PBB_GE_KCNJ10_206692_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015272 |text = ATP-activated inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3766
    | Hs_Ensembl = ENSG00000177807
    | Hs_RefseqProtein = NP_002232
    | Hs_RefseqmRNA = NM_002241
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 158273881
    | Hs_GenLoc_end = 158306662
    | Hs_Uniprot = P78508
    | Mm_EntrezGene = 16513
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_001039484
    | Mm_RefseqProtein = NP_001034573
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 10''', also known as '''KCNJ10''' or '''K<sub>ir</sub>4.1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3766| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the inward rectifier-type potassium channel family, '''K<sub>ir</sub>4.1''', characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. '''K<sub>ir</sub>4.1''', may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3766| accessdate = }}</ref>
}}


==See also==
==EAST syndrome==
Humans with [[mutation]]s in the KCNJ10 gene that cause [[Null allele|loss of function]] in related K<sup>+</sup> channels can display [[Epilepsy]], [[Ataxia]], [[Sensorineural deafness]] and [[Tubulopathy]], the [[EAST syndrome]] ([[Gitelman syndrome]] phenotype) reflecting roles for KCNJ10 gene products in the brain, [[inner ear]] and [[kidney]].<ref name="pmid19420365">{{cite journal | vauthors = Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van't Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R | title = Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations | journal = The New England Journal of Medicine | volume = 360 | issue = 19 | pages = 1960–70 | date = May 2009 | pmid = 19420365 | pmc = 3398803 | doi = 10.1056/NEJMoa0810276 }}</ref> The K<sub>ir</sub>4.1 channel is expressed in the [[Stria vascularis]] and is essential for formation of the [[endolymph]], the fluid that surrounds the [[Mechanosensation|mechanosensitive]] [[stereocilia]] of the sensory [[hair cell]]s that make [[Hearing (sense)|hearing]] possible.<ref name="pmid18218777">{{cite journal | vauthors = Nin F, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y | title = The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 5 | pages = 1751–6 | date = February 2008 | pmid = 18218777 | pmc = 2234216 | doi = 10.1073/pnas.0711463105 }}</ref>
 
== Interactions ==
 
KCNJ10 has been shown to [[Protein-protein interaction|interact]] with [[Interleukin 16]].<ref name=pmid10479680>{{cite journal | vauthors = Kurschner C, Yuzaki M | title = Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein | journal = The Journal of Neuroscience | volume = 19 | issue = 18 | pages = 7770–80 | date = September 1999 | pmid = 10479680 }}</ref>
 
== See also ==
* [[Inward-rectifier potassium ion channel]]
* [[Inward-rectifier potassium ion channel]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Satoh E, Hata Y, Takai Y, Kurachi Y | title = Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 20 | pages = 12885–8 | date = May 1997 | pmid = 9148889 | doi = 10.1074/jbc.272.20.12885 }}
| citations =
* {{cite journal | vauthors = Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ | title = CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins | journal = Molecular and Cellular Neurosciences | volume = 11 | issue = 3 | pages = 161–72 | date = June 1998 | pmid = 9647694 | doi = 10.1006/mcne.1998.0679 }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
* {{cite journal | vauthors = Kurschner C, Yuzaki M | title = Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein | journal = The Journal of Neuroscience | volume = 19 | issue = 18 | pages = 7770–80 | date = September 1999 | pmid = 10479680 | doi =  }}
*{{cite journal  | author=Shuck ME, Piser TM, Bock JH, ''et al.'' |title=Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 586-93 |year= 1997 |pmid= 8995301 |doi=  }}
* {{cite journal | vauthors = Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH | title = Co-expression of human Kir3 subunits can yield channels with different functional properties | journal = Cellular Signalling | volume = 11 | issue = 12 | pages = 871–83 | date = December 1999 | pmid = 10659995 | doi = 10.1016/S0898-6568(99)00059-5 }}
*{{cite journal  | author=Horio Y, Hibino H, Inanobe A, ''et al.'' |title=Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90. |journal=J. Biol. Chem. |volume=272 |issue= 20 |pages= 12885-8 |year= 1997 |pmid= 9148889 |doi= }}
* {{cite journal | vauthors = Fujita A, Horio Y, Higashi K, Mouri T, Hata F, Takeguchi N, Kurachi Y | title = Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump | journal = The Journal of Physiology | volume = 540 | issue = Pt 1 | pages = 85–92 | date = April 2002 | pmid = 11927671 | pmc = 2290207 | doi = 10.1113/jphysiol.2001.013439 }}
*{{cite journal  | author=Tada Y, Horio Y, Takumi T, ''et al.'' |title=Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. |journal=Genomics |volume=45 |issue= 3 |pages= 629-30 |year= 1998 |pmid= 9367690 |doi= 10.1006/geno.1997.4957 }}
* {{cite journal | vauthors = Farook VS, Hanson RL, Wolford JK, Bogardus C, Prochazka M | title = Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians | journal = Diabetes | volume = 51 | issue = 11 | pages = 3342–6 | date = November 2002 | pmid = 12401729 | doi = 10.2337/diabetes.51.11.3342 }}
*{{cite journal | author=Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |title=CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 161-72 |year= 1998 |pmid= 9647694 |doi= 10.1006/mcne.1998.0679 }}
* {{cite journal | vauthors = Konstas AA, Korbmacher C, Tucker SJ | title = Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels | journal = American Journal of Physiology. Cell Physiology | volume = 284 | issue = 4 | pages = C910-7 | date = April 2003 | pmid = 12456399 | doi = 10.1152/ajpcell.00479.2002 }}
*{{cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770-80 |year= 1999 |pmid= 10479680 |doi=  }}
* {{cite journal | vauthors = Casamassima M, D'Adamo MC, Pessia M, Tucker SJ | title = Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 43533–40 | date = October 2003 | pmid = 12923169 | doi = 10.1074/jbc.M306596200 }}
*{{cite journal | author=Schoots O, Wilson JM, Ethier N, ''et al.'' |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871-83 |year= 2000 |pmid= 10659995 |doi= }}
* {{cite journal | vauthors = Buono RJ, Lohoff FW, Sander T, Sperling MR, O'Connor MJ, Dlugos DJ, Ryan SG, Golden GT, Zhao H, Scattergood TM, Berrettini WH, Ferraro TN | title = Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility | journal = Epilepsy Research | volume = 58 | issue = 2-3 | pages = 175–83 | date = February 2004 | pmid = 15120748 | doi = 10.1016/j.eplepsyres.2004.02.003 }}
*{{cite journal | author=Fujita A, Horio Y, Higashi K, ''et al.'' |title=Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump. |journal=J. Physiol. (Lond.) |volume=540 |issue= Pt 1 |pages= 85-92 |year= 2002 |pmid= 11927671 |doi= }}
* {{cite journal | vauthors = Lenzen KP, Heils A, Lorenz S, Hempelmann A, Höfels S, Lohoff FW, Schmitz B, Sander T | title = Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy | journal = Epilepsy Research | volume = 63 | issue = 2-3 | pages = 113–8 | date = February 2005 | pmid = 15725393 | doi = 10.1016/j.eplepsyres.2005.01.002 }}
*{{cite journal | author=Farook VS, Hanson RL, Wolford JK, ''et al.'' |title=Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians. |journal=Diabetes |volume=51 |issue= 11 |pages= 3342-6 |year= 2002 |pmid= 12401729 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Konstas AA, Korbmacher C, Tucker SJ |title=Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 4 |pages= C910-7 |year= 2003 |pmid= 12456399 |doi= 10.1152/ajpcell.00479.2002 }}
* {{cite journal | vauthors = Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT | title = Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function | journal = American Journal of Physiology. Renal Physiology | volume = 292 | issue = 3 | pages = F1073-81 | date = March 2007 | pmid = 17122384 | doi = 10.1152/ajprenal.00269.2006 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Casamassima M, D'Adamo MC, Pessia M, Tucker SJ |title=Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43533-40 |year= 2003 |pmid= 12923169 |doi= 10.1074/jbc.M306596200 }}
*{{cite journal | author=Buono RJ, Lohoff FW, Sander T, ''et al.'' |title=Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. |journal=Epilepsy Res. |volume=58 |issue= 2-3 |pages= 175-83 |year= 2004 |pmid= 15120748 |doi= 10.1016/j.eplepsyres.2004.02.003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lenzen KP, Heils A, Lorenz S, ''et al.'' |title=Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. |journal=Epilepsy Res. |volume=63 |issue= 2-3 |pages= 113-8 |year= 2005 |pmid= 15725393 |doi= 10.1016/j.eplepsyres.2005.01.002 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Huang C, Sindic A, Hill CE, ''et al.'' |title=Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. |journal=Am. J. Physiol. Renal Physiol. |volume=292 |issue= 3 |pages= F1073-81 |year= 2007 |pmid= 17122384 |doi= 10.1152/ajprenal.00269.2006 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pendred  GeneReviews/NCBI/NIH/UW entry on Pendred Syndrome/DFNB4]
* {{MeshName|KCNJ10+protein,+human}}
* {{MeshName|KCNJ10+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
 
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Revision as of 06:14, 2 September 2017

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Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

ATP-sensitive inward rectifier potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene.[1][2][3][4]

Function

This gene encodes a member of the inward rectifier-type potassium channel family, Kir4.1, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. Kir4.1, may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.[4]

EAST syndrome

Humans with mutations in the KCNJ10 gene that cause loss of function in related K+ channels can display Epilepsy, Ataxia, Sensorineural deafness and Tubulopathy, the EAST syndrome (Gitelman syndrome phenotype) reflecting roles for KCNJ10 gene products in the brain, inner ear and kidney.[5] The Kir4.1 channel is expressed in the Stria vascularis and is essential for formation of the endolymph, the fluid that surrounds the mechanosensitive stereocilia of the sensory hair cells that make hearing possible.[6]

Interactions

KCNJ10 has been shown to interact with Interleukin 16.[7]

See also

References

  1. ↑ Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland NG, Jenkins NA, Kurachi Y (November 1997). "Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1". Genomics. 45 (3): 629–30. doi:10.1006/geno.1997.4957. PMID 9367690.
  2. ↑ Shuck ME, Piser TM, Bock JH, Slightom JL, Lee KS, Bienkowski MJ (January 1997). "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)". The Journal of Biological Chemistry. 272 (1): 586–93. doi:10.1074/jbc.272.1.586. PMID 8995301.
  3. ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  4. ↑ 4.0 4.1 "Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10".
  5. ↑ Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van't Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R (May 2009). "Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations". The New England Journal of Medicine. 360 (19): 1960–70. doi:10.1056/NEJMoa0810276. PMC 3398803. PMID 19420365.
  6. ↑ Nin F, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y (February 2008). "The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear". Proceedings of the National Academy of Sciences of the United States of America. 105 (5): 1751–6. doi:10.1073/pnas.0711463105. PMC 2234216. PMID 18218777.
  7. ↑ Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of Neuroscience. 19 (18): 7770–80. PMID 10479680.

Further reading

  • Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Satoh E, Hata Y, Takai Y, Kurachi Y (May 1997). "Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90". The Journal of Biological Chemistry. 272 (20): 12885–8. doi:10.1074/jbc.272.20.12885. PMID 9148889.
  • Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (June 1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Molecular and Cellular Neurosciences. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
  • Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of Neuroscience. 19 (18): 7770–80. PMID 10479680.
  • Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH (December 1999). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
  • Fujita A, Horio Y, Higashi K, Mouri T, Hata F, Takeguchi N, Kurachi Y (April 2002). "Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump". The Journal of Physiology. 540 (Pt 1): 85–92. doi:10.1113/jphysiol.2001.013439. PMC 2290207. PMID 11927671.
  • Farook VS, Hanson RL, Wolford JK, Bogardus C, Prochazka M (November 2002). "Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians". Diabetes. 51 (11): 3342–6. doi:10.2337/diabetes.51.11.3342. PMID 12401729.
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