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{{Infobox_gene}}
'''G-protein coupled receptor family C group 5 member B''' is a [[protein]] that in humans is encoded by the ''GPRC5B'' [[gene]].<ref name="pmid10493829">{{cite journal |vauthors=Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | date = Nov 1999 | pmid = 10493829 | pmc =  | doi = 10.1006/geno.1999.5927 }}</ref><ref name="pmid10783259">{{cite journal |vauthors=Bräuner-Osborne H, Krogsgaard-Larsen P | title = Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain | journal = Genomics | volume = 65 | issue = 2 | pages = 121–8 | date = Jul 2000 | pmid = 10783259 | pmc =  | doi = 10.1006/geno.2000.6164 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704| accessdate = }}</ref>


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.<ref name="entrez" />
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor, family C, group 5, member B
| HGNCid = 13308
| Symbol = GPRC5B
| AltSymbols =; RAIG-2; RAIG2
| OMIM = 605948
| ECnumber = 
| Homologene = 9435
| MGIid = 1927596
| GeneAtlas_image1 = PBB_GE_GPRC5B_203632_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPRC5B_203631_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005118 |text = sevenless binding}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51704
    | Hs_Ensembl = ENSG00000167191
    | Hs_RefseqProtein = NP_057319
    | Hs_RefseqmRNA = NM_016235
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 19777796
    | Hs_GenLoc_end = 19803652
    | Hs_Uniprot = Q9NZH0
    | Mm_EntrezGene = 64297
    | Mm_Ensembl = ENSMUSG00000008734
    | Mm_RefseqmRNA = NM_022420
    | Mm_RefseqProtein = NP_071865
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 118763196
    | Mm_GenLoc_end = 118786310
    | Mm_Uniprot = Q9JMF0
  }}
}}
'''G protein-coupled receptor, family C, group 5, member B''', also known as '''GPRC5B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51704| accessdate = }}</ref>
}}


==See also==
==See also==
Line 64: Line 13:


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal |vauthors=Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN | title = Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) | journal = Genomics | volume = 67 | issue = 1 | pages = 8–18 | year = 2001 | pmid = 10945465 | doi = 10.1006/geno.2000.6226 }}
| citations =
*{{cite journal  | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal | author=Bräuner-Osborne H, Krogsgaard-Larsen P |title=Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. |journal=Genomics |volume=65 |issue= 2 |pages= 121-8 |year= 2000 |pmid= 10783259 |doi= 10.1006/geno.2000.6164 }}
*{{cite journal  | author=Robbins MJ, Michalovich D, Hill J, ''et al.'' |title=Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). |journal=Genomics |volume=67 |issue= 1 |pages= 8-18 |year= 2001 |pmid= 10945465 |doi= 10.1006/geno.2000.6226 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
}}
{{refend}}
{{refend}}
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2960 | title = GPRC5 Receptors: RAIG<sub>2</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g3}}
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 09:16, 10 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.[1][2][3]

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.[3]

See also

References

  1. ↑ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  2. ↑ Bräuner-Osborne H, Krogsgaard-Larsen P (Jul 2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  3. ↑ 3.0 3.1 "Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B".

Further reading

  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2001). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.

External links

  • "GPRC5 Receptors: RAIG2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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