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{{Infobox_gene}}
'''Probable G-protein coupled receptor 158''' is a [[protein]] that in humans is encoded by the ''GPR158'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR158 G protein-coupled receptor 158| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57512| accessdate = }}</ref>


GPR158 is an orphan [[class C GPCR]]. It is highly expressed in the brain where it binds to [[RGS7]], an inhibitor of G<sub>i/o</sub>-coupled [[GPCR]] signaling, localizing it to the plasma membrane.<ref name="pmid22689652">{{cite journal | vauthors = Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA | title = GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes | journal = J. Cell Biol. | volume = 197 | issue = 6 | pages = 711–9 | year = 2012 | pmid = 22689652 | pmc = 3373406 | doi = 10.1083/jcb.201202123 }}</ref>


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GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.<ref name="pmid23451275">{{cite journal | vauthors = Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME | title = GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role | journal = PLoS ONE | volume = 8 | issue = 2 | pages = e57843 | year = 2013 | pmid = 23451275 | pmc = 3581496 | doi = 10.1371/journal.pone.0057843 | url = }} {{open access}}</ref>
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GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.<ref name="pmid25693195">{{cite journal | vauthors = Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME | title = Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression | journal = PLoS ONE | volume = 10 | issue = 2 | pages = e0117758 | year = 2015 | pmid = 25693195 | pmc = 4333349 | doi = 10.1371/journal.pone.0117758 }} {{open access}}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = G protein-coupled receptor 158
| HGNCid = 23689
| Symbol = GPR158
| AltSymbols =; FLJ37801; KIAA1136; RP11-59G22.1
| OMIM = 
| ECnumber = 
| Homologene = 19381
| MGIid = 2441697
| GeneAtlas_image1 = PBB_GE_GPR158_gnf1h10155_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57512
    | Hs_Ensembl = ENSG00000151025
    | Hs_RefseqProtein = NP_065803
    | Hs_RefseqmRNA = NM_020752
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 25503997
    | Hs_GenLoc_end = 25931161
    | Hs_Uniprot = Q5T848
    | Mm_EntrezGene = 241263
    | Mm_Ensembl = ENSMUSG00000045967
    | Mm_RefseqmRNA = NM_175706
    | Mm_RefseqProtein = NP_783637
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 21285321
    | Mm_GenLoc_end = 21748298
    | Mm_Uniprot = Q8BSU1
  }}
}}
'''G protein-coupled receptor 158''', also known as '''GPR158''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR158 G protein-coupled receptor 158| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57512| accessdate = }}</ref>


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== References ==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{G protein-coupled receptors|g3}}
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Hirosawa M, Nagase T, Ishikawa K, ''et al.'' |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329-36 |year= 2000 |pmid= 10574461 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Schiöth HB |title=The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. |journal=Gene |volume=362 |issue=  |pages= 70-84 |year= 2006 |pmid= 16229975 |doi= 10.1016/j.gene.2005.07.029 }}
}}
{{refend}}


{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
 
{{transmembranereceptor-stub}}

Revision as of 01:00, 27 October 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]

GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]

GPR158 is also expressed at lower levels in other organs. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[3]

GPR158 is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines. It is linked to neuroendocrine differentiation.[4]

References

  1. ↑ "Entrez Gene: GPR158 G protein-coupled receptor 158".
  2. ↑ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
  3. ↑ Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLoS ONE. 8 (2): e57843. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275. open access publication – free to read
  4. ↑ Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLoS ONE. 10 (2): e0117758. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195. open access publication – free to read


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