GABBR1

Gamma-aminobutyric acid (GABA) B receptor, 1
PDB rendering based on 1srz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1srz​, 1ss2​
Identifiers
Symbols	GABBR1 ; GABAB(1e); GABABR1; GABBR1-3; GPRC3A; dJ271M21.1.1; dJ271M21.1.2; hGB1a
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1132
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Gamma-aminobutyric acid (GABA) B receptor, 1, also known as GABBR1, is a human gene.

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

See also

• GABAB receptor

Further reading

• Fraser DD, Mudrick-Donnon LA, MacVicar BA (1994). "Astrocytic GABA receptors". Glia. 11 (2): 83–93. doi:10.1002/glia.440110203. PMID 7927650.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Kaupmann K, Huggel K, Heid J; et al. (1997). "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors". Nature. 386 (6622): 239–46. doi:10.1038/386239a0. PMID 9069281.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grifa A, Totaro A, Rommens JM; et al. (1998). "GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene". Biochem. Biophys. Res. Commun. 250 (2): 240–5. doi:10.1006/bbrc.1998.9296. PMID 9753614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goei VL, Choi J, Ahn J; et al. (1999). "Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization". Biol. Psychiatry. 44 (8): 659–66. PMID 9798068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaupmann K, Schuler V, Mosbacher J; et al. (1999). "Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14991–6. PMID 9844003.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• White JH, Wise A, Main MJ; et al. (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuner R, Köhr G, Grünewald S; et al. (1999). "Role of heteromer formation in GABAB receptor function". Science. 283 (5398): 74–7. PMID 9872744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Makoff A (1999). "Molecular cloning of human GABABR1 and its tissue distribution". Brain Res. Mol. Brain Res. 64 (1): 137–40. PMID 9889352.
• Peters HC, Kämmer G, Volz A; et al. (2000). "Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy". Neurogenetics. 2 (1): 47–54. PMID 9933300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ng GY, Clark J, Coulombe N; et al. (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. PMID 10075644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sander T, Peters C, Kämmer G; et al. (1999). "Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy". Am. J. Med. Genet. 88 (4): 305–10. PMID 10402495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wise A, Green A, Main MJ; et al. (1999). "Calcium sensing properties of the GABA(B) receptor". Neuropharmacology. 38 (11): 1647–56. PMID 10587080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sullivan R, Chateauneuf A, Coulombe N; et al. (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwarz DA, Barry G, Eliasof SD; et al. (2000). "Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor". J. Biol. Chem. 275 (41): 32174–81. doi:10.1074/jbc.M005333200. PMID 10906333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• White JH, McIllhinney RA, Wise A; et al. (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMID 11087824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Couve A, Kittler JT, Uren JM; et al. (2001). "Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins". Mol. Cell. Neurosci. 17 (2): 317–28. doi:10.1006/mcne.2000.0938. PMID 11178869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muñoz A, Arellano JI, DeFelipe J (2002). "GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy". J. Comp. Neurol. 449 (2): 166–79. doi:10.1002/cne.10287. PMID 12115687.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.