FZD5: Difference between revisions

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{{Infobox_gene}}
 
'''Frizzled-5''' is a [[protein]] that in humans is encoded by the ''FZD5'' [[gene]].<ref name="pmid8626800">{{cite journal |vauthors=Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled | journal = J Biol Chem | volume = 271 | issue = 8 | pages = 4468–76 |date=Jun 1996 | pmid = 8626800 | pmc =  | doi =10.1074/jbc.271.8.4468 }}</ref><ref name="pmid11408929">{{cite journal |vauthors=Saitoh T, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region | journal = Int J Oncol | volume = 19 | issue = 1 | pages = 105–10 |date=Jun 2001 | pmid = 11408929 | pmc =  | doi =  10.3892/ijo.19.1.105}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7855| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Frizzled homolog 5 (Drosophila)
| HGNCid = 4043
| Symbol = FZD5
| AltSymbols =; C2orf31; DKFZP434E2135; HFZ5; MGC129692
| OMIM = 601723
| ECnumber =
| Homologene = 2590
| MGIid = 108571
  | GeneAtlas_image1 = PBB_GE_FZD5_206136_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007164 |text = establishment of tissue polarity}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0048469 |text = cell maturation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7855
    | Hs_Ensembl = ENSG00000163251
    | Hs_RefseqProtein = NP_003459
    | Hs_RefseqmRNA = NM_003468
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 208338962
    | Hs_GenLoc_end = 208342363
    | Hs_Uniprot = Q13467
    | Mm_EntrezGene = 14367
    | Mm_Ensembl = ENSMUSG00000045005
    | Mm_RefseqmRNA = NM_001033193
    | Mm_RefseqProtein = NP_001028365
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 64668689
    | Mm_GenLoc_end = 64672026
    | Mm_Uniprot = Q149L3
  }}
}}
'''Frizzled homolog 5 (Drosophila)''', also known as '''FZD5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7855| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD5 protein is believed to be the receptor for the Wnt5A ligand.<ref name="entrez">{{cite web | title = Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7855| accessdate = }}</ref>
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD5 protein is believed to be the receptor for the Wnt5A ligand.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist}}
{{reflist}}
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3063 | title = Frizzled Receptors: FZD<sub>5</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wang Y, Macke JP, Abella BS, ''et al.'' |title=A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4468-76 |year= 1996 |pmid= 8626800 |doi=  }}
*{{cite journal  |vauthors=He X, Saint-Jeannet JP, Wang Y |title=A member of the Frizzled protein family mediating axis induction by Wnt-5A. |journal=Science |volume=275 |issue= 5306 |pages= 1652–4 |year= 1997 |pmid= 9054360 |doi=10.1126/science.275.5306.1652 |display-authors=etal}}
*{{cite journal  | author=He X, Saint-Jeannet JP, Wang Y, ''et al.'' |title=A member of the Frizzled protein family mediating axis induction by Wnt-5A. |journal=Science |volume=275 |issue= 5306 |pages= 1652-4 |year= 1997 |pmid= 9054360 |doi=  }}
*{{cite journal  |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770  | pmc=21233 |display-authors=etal}}
*{{cite journal  | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi=  }}
*{{cite journal  |vauthors=Tanaka S, Akiyoshi T, Mori M |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=10.1073/pnas.95.17.10164  | pmc=21479 |display-authors=etal}}
*{{cite journal  | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi=  }}
*{{cite journal  |vauthors=Tamai K, Semenov M, Kato Y |title=LDL-receptor-related proteins in Wnt signal transduction. |journal=Nature |volume=407 |issue= 6803 |pages= 530–5 |year= 2000 |pmid= 11029007 |doi= 10.1038/35035117 |display-authors=etal}}
*{{cite journal  | author=Tamai K, Semenov M, Kato Y, ''et al.'' |title=LDL-receptor-related proteins in Wnt signal transduction. |journal=Nature |volume=407 |issue= 6803 |pages= 530-5 |year= 2000 |pmid= 11029007 |doi= 10.1038/35035117 }}
*{{cite journal  |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=Yao R, Maeda T, Takada S, Noda T |title=Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 771–8 |year= 2001 |pmid= 11520064 |doi= 10.1006/bbrc.2001.5430 }}
*{{cite journal | author=Saitoh T, Hirai M, Katoh M |title=Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. |journal=Int. J. Oncol. |volume=19 |issue= 1 |pages= 105-10 |year= 2001 |pmid= 11408929 |doi= }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Yao R, Maeda T, Takada S, Noda T |title=Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 771-8 |year= 2001 |pmid= 11520064 |doi= 10.1006/bbrc.2001.5430 }}
*{{cite journal  |vauthors=Weidler C, Schaumburger J, Miller LE |title=Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation. |journal=J. Rheumatol. |volume=31 |issue= 9 |pages= 1874–5 |year= 2004 |pmid= 15338479 |doi=  |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}}
*{{cite journal  | author=Weidler C, Schaumburger J, Miller LE, ''et al.'' |title=Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation. |journal=J. Rheumatol. |volume=31 |issue= 9 |pages= 1874-5 |year= 2004 |pmid= 15338479 |doi=  }}
*{{cite journal  |vauthors=Holmen SL, Robertson SA, Zylstra CR, Williams BO |title=Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 533–9 |year= 2005 |pmid= 15694380 |doi= 10.1016/j.bbrc.2005.01.009 }}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal  |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | author=Holmen SL, Robertson SA, Zylstra CR, Williams BO |title=Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 533-9 |year= 2005 |pmid= 15694380 |doi= 10.1016/j.bbrc.2005.01.009 }}
*{{cite journal  |vauthors=Blumenthal A, Ehlers S, Lauber J |title=The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. |journal=Blood |volume=108 |issue= 3 |pages= 965–73 |year= 2006 |pmid= 16601243 |doi= 10.1182/blood-2005-12-5046 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  |vauthors=Yamamoto H, Komekado H, Kikuchi A |title=Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. |journal=Dev. Cell |volume=11 |issue= 2 |pages= 213–23 |year= 2006 |pmid= 16890161 |doi= 10.1016/j.devcel.2006.07.003 }}
*{{cite journal  | author=Blumenthal A, Ehlers S, Lauber J, ''et al.'' |title=The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. |journal=Blood |volume=108 |issue= 3 |pages= 965-73 |year= 2006 |pmid= 16601243 |doi= 10.1182/blood-2005-12-5046 }}
*{{cite journal  |vauthors=Katoh Y, Katoh M |title=Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. |journal=Int. J. Oncol. |volume=30 |issue= 3 |pages= 751–5 |year= 2007 |pmid= 17273778 |doi=  10.3892/ijo.30.3.751}}
*{{cite journal  | author=Yamamoto H, Komekado H, Kikuchi A |title=Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. |journal=Dev. Cell |volume=11 |issue= 2 |pages= 213-23 |year= 2006 |pmid= 16890161 |doi= 10.1016/j.devcel.2006.07.003 }}
*{{cite journal  | author=Katoh Y, Katoh M |title=Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. |journal=Int. J. Oncol. |volume=30 |issue= 3 |pages= 751-5 |year= 2007 |pmid= 17273778 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}
[[Category:G protein coupled receptors]]
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{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3]

See also

References

  1. ↑ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
  2. ↑ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.
  3. ↑ 3.0 3.1 "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

External links

  • "Frizzled Receptors: FZD5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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