Complement component 1r
| complement component 1, r subcomponent | |
|---|---|
| Identifiers | |
| Symbol | C1R |
| Entrez | 715 |
| HUGO | 1246 |
| OMIM | 216950 |
| RefSeq | NM_001733 |
| UniProt | P00736 |
| Other data | |
| EC number | 3.4.21.41 |
| Locus | Chr. 12 p13 |
Complement component 1r (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase) is a protein involved in the complement system of the innate immune system.[1][2][3]
C1r is an enzyme that catalyses the following chemical reaction:
- Selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form C verbar 1s (EC 3.4.21.42)
References
- ↑ Sim, R.B. (1981). "The human complement system serine proteases C1r and C1s and their proenzymes". Methods Enzymol. 80: 26–42. doi:10.1016/s0076-6879(81)80006-7. PMID 6281620.
- ↑ Leytus, S.P.; Kurachi, K.; Sakariassen, K.S.; Davie, E.W. (1986). "Nucleotide sequence of the cDNA coding for human complement C1r". Biochemistry. 25: 4855–4863. doi:10.1021/bi00365a020. PMID 3021205.
- ↑ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
External links
- Complement+C1r at the US National Library of Medicine Medical Subject Headings (MeSH)
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