|Chymase with PMSF bound PDB: 1KLT|
chymase 1, mast cell
|Locus||Chr. 14 q11.2|
Chymases (EC 22.214.171.124, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8). They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by mucosal mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response. Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis.
Because of its role in inflammation it has been investigated as a target in the treatment of asthma.
- Caughey, GH. Mast cell tryptases and chymases in inflammation and host defense. Immu Revs 2007 (217): 141-154. PubMed
- de Garavilla et al. Journal of Biochemistry 2005(280) pp.18001-18007.