This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
The protein is implicated in epithelialsodium channel regulation[4] and may help regulate a variety of tissue functions that involve a sodium channel.[5]
References
↑Yu JX, Chao L, Ward DC, Chao J (Mar 1996). "Structure and chromosomal localization of the human prostasin (PRSS8) gene". Genomics. 32 (3): 334–40. doi:10.1006/geno.1996.0127. PMID8838796.
↑Yu JX, Chao L, Chao J (Jun 1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA". The Journal of Biological Chemistry. 270 (22): 13483–9. doi:10.1074/jbc.270.22.13483. PMID7768952.
Yu JX, Chao L, Chao J (Jul 1994). "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland". The Journal of Biological Chemistry. 269 (29): 18843–8. PMID8034638.
Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, Thaler CD, Chai KX (Jun 2001). "Prostasin is a glycosylphosphatidylinositol-anchored active serine protease". The Journal of Biological Chemistry. 276 (24): 21434–42. doi:10.1074/jbc.M011423200. PMID11274175.
Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE (Mar 2002). "Regulation of the epithelial sodium channel by serine proteases in human airways". The Journal of Biological Chemistry. 277 (10): 8338–45. doi:10.1074/jbc.M105044200. PMID11756432.
Wang C, Chao J, Chao L (Apr 2003). "Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284 (4): R1031–6. doi:10.1152/ajpregu.00660.2002. PMID12626364.
Fan B, Wu TD, Li W, Kirchhofer D (Oct 2005). "Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin". The Journal of Biological Chemistry. 280 (41): 34513–20. doi:10.1074/jbc.M502119200. PMID16103126.
Chen M, Chen LM, Chai KX (Jun 2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The Prostate. 66 (9): 911–20. doi:10.1002/pros.20325. PMID16541421.
Rohan S, Tu JJ, Kao J, Mukherjee P, Campagne F, Zhou XK, Hyjek E, Alonso MA, Chen YT (Dec 2006). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes". Clinical Cancer Research. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID17145811.