Membrane-bound transcription factor peptidase, site 1

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membrane-bound transcription factor peptidase, site 1
Identifiers
SymbolMBTPS1
Alt. symbolsS1P
Entrez8720
HUGO15456
OMIM603355
RefSeqNM_003791
UniProtQ14703
Other data
EC number3.4.21.112
LocusChr. 16 q24

Membrane-bound transcription factor peptidase, site 1 also known as Site-1 Protease (S1P) is an enzyme (EC 3.4.21.112) encoded by the MBTPS1 gene which cleaves the endoplasmic reticulum loop of sterol regulatory element binding protein (SREBP) transcription factors.[1][2]

See also

References

  1. Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMID 10500120.
  2. Nakajima T, Iwaki K, Kodama T, Inazawa J, Emi M (2000). "Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene". J. Hum. Genet. 45 (4): 212–7. doi:10.1007/s100380070029. PMID 10944850.

External links


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