Brain-specific angiogenesis inhibitor 3: Difference between revisions

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imported>Ser Amantio di Nicolao
 
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{{Infobox_gene}}
 
'''Brain-specific angiogenesis inhibitor 3''' is a [[protein]] that in humans is encoded by the ''BAI3'' [[gene]].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenet Cell Genet | volume = 79 | issue = 1-2 | pages = 103–8 |date=Apr 1998 | pmid = 9533023 | pmc =  | doi =10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Brain-specific angiogenesis inhibitor 3
| HGNCid = 945
| Symbol = BAI3
| AltSymbols =; KIAA0550; MGC133100
| OMIM = 602684
| ECnumber = 
| Homologene = 1289
| MGIid = 2441837
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0016527 |text = brain-specific angiogenesis inhibitor activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 577
    | Hs_Ensembl = ENSG00000135298
    | Hs_RefseqProtein = NP_001695
    | Hs_RefseqmRNA = NM_001704
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 69401980
    | Hs_GenLoc_end = 70156124
    | Hs_Uniprot = O60242
    | Mm_EntrezGene = 210933
    | Mm_Ensembl = ENSMUSG00000033569
    | Mm_RefseqmRNA = NM_175642
    | Mm_RefseqProtein = NP_783573
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 25012714
    | Mm_GenLoc_end = 25771306
    | Mm_Uniprot = Q499E3
  }}
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'''Brain-specific angiogenesis inhibitor 3''', also known as '''BAI3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577| accessdate = }}</ref>
| summary_text = BAI1, a p53-target gene, encodes brain-specific [[angiogenesis]] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" />
}}
}}
The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108</ref>  BaI3 is expressed in neural tissues of the central nervous system.  BaI3 has been shown to have a high affinity for C1q proteins.  C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ADGRB3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  |display-authors=etal}}
*{{cite journal  | author=Shiratsuchi T, Nishimori H, Ichise H, ''et al.'' |title=Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 103-8 |year= 1998 |pmid= 9533023 |doi=  }}
*{{cite journal  | vauthors=Nagase T, Ishikawa K, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Bjarnadóttir TK, Fredriksson R, Höglund PJ |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |display-authors=etal}}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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SpeciesHumanMouse
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Wikidata
View/Edit Human

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[1][2]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[3] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

References

  1. ↑ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
  2. ↑ 2.0 2.1 "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
  3. ↑ Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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