Beta-3 adrenergic receptor

Adrenergic, beta-3-, receptor
Identifiers
Symbols	ADRB3 ; BETA3AR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37250
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The beta-3 adrenergic receptor (β₃ adrenoreceptor), also known as ADRB3, is an beta-adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Functions

Actions of the β₃ receptor include:

• Enhancement of lipolysis in adipose tissue.
• Thermogenesis in skeletal muscle

It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis.

Mechanism

Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of the G proteins of the type G_s.

Agonists

• L-796568
• CL 316,243
• LY 368842
• Ro 40-2148

Antagonists

(Beta blockers)

See also

• Other adrenergic receptors
  • Alpha-1 adrenergic receptor
  • Alpha-2 adrenergic receptor
  • Beta-1 adrenergic receptor
  • Beta-2 adrenergic receptor

Further reading

• Granneman JG, Lahners KN, Rao DD (1993). "Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block". Mol. Pharmacol. 42 (6): 964–70. PMID 1336117.CS1 maint: Multiple names: authors list (link)
• Nahmias C, Blin N, Elalouf JM; et al. (1991). "Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes". EMBO J. 10 (12): 3721–7. PMID 1718744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Emorine LJ, Marullo S, Briend-Sutren MM; et al. (1989). "Molecular characterization of the human beta 3-adrenergic receptor". Science. 245 (4922): 1118–21. PMID 2570461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guan XM, Amend A, Strader CD (1995). "Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor". Mol. Pharmacol. 48 (3): 492–8. PMID 7565630.CS1 maint: Multiple names: authors list (link)
• Rodriguez M, Carillon C, Coquerel A; et al. (1995). "Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain". Brain Res. Mol. Brain Res. 29 (2): 369–75. PMID 7609625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clément K, Vaisse C, Manning BS; et al. (1995). "Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity". N. Engl. J. Med. 333 (6): 352–4. PMID 7609752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dib A, Adélaïde J, Chaffanet M; et al. (1995). "Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma". Oncogene. 10 (5): 995–1001. PMID 7898940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahmoudian M (1994). "The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study". Journal of molecular graphics. 12 (1): 22–8, 34. PMID 8011597.
• Wilkie TM, Chen Y, Gilbert DJ; et al. (1994). "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors". Genomics. 18 (2): 175–84. doi:10.1006/geno.1993.1452. PMID 8288218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krief S, Lönnqvist F, Raimbault S; et al. (1993). "Tissue distribution of beta 3-adrenergic receptor mRNA in man". J. Clin. Invest. 91 (1): 344–9. PMID 8380813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Spronsen A, Nahmias C, Krief S; et al. (1993). "The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes". Eur. J. Biochem. 213 (3): 1117–24. PMID 8389293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lelias JM, Kaghad M, Rodriguez M; et al. (1993). "Molecular cloning of a human beta 3-adrenergic receptor cDNA". FEBS Lett. 324 (2): 127–30. PMID 8389717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Candelore MR, Deng L, Tota LM; et al. (1996). "Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant". Endocrinology. 137 (6): 2638–41. PMID 8641219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujisawa T, Ikegami H, Yamato E; et al. (1996). "Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain". Diabetologia. 39 (3): 349–52. PMID 8721782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Higashi K, Ishikawa T, Ito T; et al. (1997). "Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese". Biochem. Biophys. Res. Commun. 232 (3): 728–30. doi:10.1006/bbrc.1997.6339. PMID 9126344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffstedt J, Poirier O, Thörne A; et al. (1999). "Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function". Diabetes. 48 (1): 203–5. PMID 9892244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Halushka MK, Fan JB, Bentley K; et al. (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis". Nat. Genet. 22 (3): 239–47. doi:10.1038/10297. PMID 10391210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Sasaki N, Asano A; et al. (2000). "Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes". Horm. Metab. Res. 32 (3): 91–6. PMID 10786926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao W, Luttrell LM, Medvedev AV; et al. (2001). "Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation". J. Biol. Chem. 275 (49): 38131–4. doi:10.1074/jbc.C000592200. PMID 11013230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Russell ST, Hirai K, Tisdale MJ (2002). "Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor". Br. J. Cancer. 86 (3): 424–8. doi:10.1038/sj.bjc.6600086. PMID 11875710.CS1 maint: Multiple names: authors list (link)