Alpha-1B adrenergic receptor: Difference between revisions

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{{Infobox_gene}}
 
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Adrenergic, alpha-1B-, receptor
| HGNCid = 278
| Symbol = ADRA1B
| AltSymbols =; ADRA1; ALPHA1BAR
| OMIM = 104220
| ECnumber = 
| Homologene = 55477
| MGIid = 104774
| GeneAtlas_image1 = PBB_GE_ADRA1B_207589_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004935 |text = adrenoceptor activity}} {{GNF_GO|id=GO:0004937 |text = alpha1-adrenergic receptor activity}}
| Component = {{GNF_GO|id=GO:0000299 |text = integral to membrane of membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001974 |text = blood vessel remodeling}} {{GNF_GO|id=GO:0001975 |text = response to amphetamine}} {{GNF_GO|id=GO:0001987 |text = vasoconstriction of artery during baroreceptor response to lowering of blood pressure}} {{GNF_GO|id=GO:0001996 |text = positive regulation of heart contraction rate by epinephrine-norepinephrine}} {{GNF_GO|id=GO:0001997 |text = increased strength of heart contraction by epinephrine-norepinephrine}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007512 |text = adult heart development}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008542 |text = visual learning}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0035265 |text = organ growth}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}} {{GNF_GO|id=GO:0043278 |text = response to morphine}} {{GNF_GO|id=GO:0045818 |text = negative regulation of glycogen catabolic process}} {{GNF_GO|id=GO:0045819 |text = positive regulation of glycogen catabolic process}} {{GNF_GO|id=GO:0048148 |text = behavioral response to cocaine}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 147
    | Hs_Ensembl = ENSG00000170214
    | Hs_RefseqProtein = NP_000670
    | Hs_RefseqmRNA = NM_000679
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 159276318
    | Hs_GenLoc_end = 159332595
    | Hs_Uniprot = P35368
    | Mm_EntrezGene = 11548
    | Mm_Ensembl = ENSMUSG00000050541
    | Mm_RefseqmRNA = NM_007416
    | Mm_RefseqProtein = NP_031442
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 43618029
    | Mm_GenLoc_end = 43744633
    | Mm_Uniprot = Q05D47
  }}
}}
The '''alpha-1B adrenergic receptor''' (α<sub>1B</sub> adrenoreceptor), also known as '''ADRA1B''', is an [[alpha-1 adrenergic receptor]], and also denotes the human [[gene]] encoding it.<ref name="entrez" />
The '''alpha-1B adrenergic receptor''' (α<sub>1B</sub> adrenoreceptor), also known as '''ADRA1B''', is an [[alpha-1 adrenergic receptor]], and also denotes the human [[gene]] encoding it.<ref name="entrez" />
<!-- The PBB_Summary template is not automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Continue updates. -->
{{PBB_Summary
| section_title =
| summary_text =


==Receptor==
==Receptor==
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==Gene==
==Gene==
This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a [[protooncogene]]. This gene comprises 2 [[mRNA exon|exons]] and a single large intron of at least 20 kb that interrupts the coding region.<ref name="entrez">{{cite web | title = Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147| accessdate = }}</ref>
This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a [[protooncogene]]. This gene comprises 2 [[mRNA exon|exons]] and a single large intron of at least 20 kb that interrupts the coding region.<ref name="entrez">{{cite web | title = Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147| accessdate = }}</ref>
}}
 
==Ligands==
; Antagonists
* [[L-765,314]]<ref name="pmid12086979">{{cite journal | vauthors = Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE | title = Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist | journal = Br. J. Pharmacol. | volume = 136 | issue = 5 | pages = 701–8 | year = 2002 | pmid = 12086979 | pmc = 1573401 | doi = 10.1038/sj.bjp.0704773  }}</ref>
* [[Risperidone]]
 
==Interactions==
Alpha-1B adrenergic receptor has been shown to [[Protein-protein interaction|interact]] with [[AP2M1]].<ref name = pmid12644451>{{cite journal | date = May 2003 | vauthors = Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S | title = The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19331–40 | pmid = 12644451 | doi = 10.1074/jbc.M302110200}}</ref> A role in regulation of dopaminergic neurotransmission has also been suggested.<ref name = "pmid11923452">{{cite journal | vauthors = Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP | date = April 2002 | title = Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates | journal = J. Neurosci. | volume = 22 | issue = 7 | pages = 2873–84 | pmid = 11923452 | doi =}}</ref><ref name = "pmid15579162">{{cite journal | vauthors = Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP | date = December 2004 | title = 5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants | journal = Eur. J. Neurosci. | volume = 20 | issue = 11 | pages = 3073–84 | pmid = 15579162 | doi = 10.1111/j.1460-9568.2004.03805.x}}</ref>


==See also==
==See also==
Line 66: Line 20:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ADRA1B}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Ramarao CS, Denker JM, Perez DM |title=Genomic organization and expression of the human alpha 1B-adrenergic receptor. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21936–45 |year= 1992 |pmid= 1328250 |doi=  |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S |title=G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11354–8 |year= 1992 |pmid= 1662393 |doi=10.1073/pnas.88.24.11354 | pmc=53133  |url=https://dukespace.lib.duke.edu/dspace/bitstream/10161/7850/1/Allen_G%20protein%20coupled%20receptor%20genes%20as%20protooncogenes_constitutively%20activating%20mutation.pdf }}
*{{cite journal  | author=Ramarao CS, Denker JM, Perez DM, ''et al.'' |title=Genomic organization and expression of the human alpha 1B-adrenergic receptor. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21936-45 |year= 1992 |pmid= 1328250 |doi=  }}
*{{cite journal  | vauthors=Lomasney JW, Cotecchia S, Lorenz W |title=Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5 |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6365–9 |year= 1991 |pmid= 1706716 |doi=  |display-authors=etal}}
*{{cite journal  | author=Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S |title=G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11354-8 |year= 1992 |pmid= 1662393 |doi=  }}
*{{cite journal  | vauthors=Yang-Feng TL, Xue FY, Zhong WW |title=Chromosomal organization of adrenergic receptor genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1516–20 |year= 1990 |pmid= 2154750 |doi=10.1073/pnas.87.4.1516  | pmc=53506 |display-authors=etal}}
*{{cite journal  | author=Lomasney JW, Cotecchia S, Lorenz W, ''et al.'' |title=Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6365-9 |year= 1991 |pmid= 1706716 |doi=  }}
*{{cite journal  | vauthors=Schwinn DA, Johnston GI, Page SO |title=Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues |journal=J. Pharmacol. Exp. Ther. |volume=272 |issue= 1 |pages= 134–42 |year= 1995 |pmid= 7815325 |doi=  |display-authors=etal}}
*{{cite journal  | author=Yang-Feng TL, Xue FY, Zhong WW, ''et al.'' |title=Chromosomal organization of adrenergic receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1516-20 |year= 1990 |pmid= 2154750 |doi=  }}
*{{cite journal  | vauthors=Weinberg DH, Trivedi P, Tan CP |title=Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1296–304 |year= 1994 |pmid= 8024574 |doi=10.1006/bbrc.1994.1845 |display-authors=etal}}
*{{cite journal  | author=Schwinn DA, Johnston GI, Page SO, ''et al.'' |title=Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. |journal=J. Pharmacol. Exp. Ther. |volume=272 |issue= 1 |pages= 134-42 |year= 1995 |pmid= 7815325 |doi=  }}
*{{cite journal  | vauthors=Forray C, Bard JA, Wetzel JM |title=The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 703–8 |year= 1994 |pmid= 8183249 |doi=  |display-authors=etal}}
*{{cite journal  | author=Weinberg DH, Trivedi P, Tan CP, ''et al.'' |title=Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1296-304 |year= 1994 |pmid= 8024574 |doi=  }}
*{{cite journal  | vauthors=Diviani D, Lattion AL, Larbi N |title=Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5049–58 |year= 1996 |pmid= 8617782 |doi=10.1074/jbc.271.9.5049  |display-authors=etal}}
*{{cite journal  | author=Forray C, Bard JA, Wetzel JM, ''et al.'' |title=The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 703-8 |year= 1994 |pmid= 8183249 |doi=  }}
*{{cite journal  | vauthors=Diviani D, Lattion AL, Cotecchia S |title=Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28712–9 |year= 1997 |pmid= 9353340 |doi=10.1074/jbc.272.45.28712  }}
*{{cite journal  | author=Diviani D, Lattion AL, Larbi N, ''et al.'' |title=Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5049-58 |year= 1996 |pmid= 8617782 |doi= }}
*{{cite journal  | vauthors=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11) |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101–5 |year= 1998 |pmid= 9481484 |doi=10.1016/S0898-6568(97)00097-1 }}
*{{cite journal  | author=Diviani D, Lattion AL, Cotecchia S |title=Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28712-9 |year= 1997 |pmid= 9353340 |doi= }}
*{{cite journal  | vauthors=Sasaguri T, Teruya H, Ishida A |title=Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 25–30 |year= 2000 |pmid= 10652206 |doi= 10.1006/bbrc.1999.2066 |display-authors=etal}}
*{{cite journal  | author=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11). |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101-5 |year= 1998 |pmid= 9481484 |doi=  }}
*{{cite journal  | vauthors=Minneman KP, Lee D, Zhong H |title=Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes |journal=J. Neurochem. |volume=74 |issue= 6 |pages= 2392–400 |year= 2000 |pmid= 10820200 |doi=10.1046/j.1471-4159.2000.0742392.x |display-authors=etal}}
*{{cite journal  | author=Sasaguri T, Teruya H, Ishida A, ''et al.'' |title=Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 25-30 |year= 2000 |pmid= 10652206 |doi= 10.1006/bbrc.1999.2066 }}
*{{cite journal  | vauthors=Shibata K, Katsuma S, Koshimizu T |title=alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 672–8 |year= 2003 |pmid= 12409310 |doi= 10.1074/jbc.M201375200 |display-authors=etal}}
*{{cite journal  | author=Minneman KP, Lee D, Zhong H, ''et al.'' |title=Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes. |journal=J. Neurochem. |volume=74 |issue= 6 |pages= 2392-400 |year= 2000 |pmid= 10820200 |doi=  }}
*{{cite journal  | vauthors=Diviani D, Lattion AL, Abuin L |title=The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19331–40 |year= 2003 |pmid= 12644451 |doi= 10.1074/jbc.M302110200 |display-authors=etal}}
*{{cite journal  | author=Shibata K, Katsuma S, Koshimizu T, ''et al.'' |title=alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 672-8 |year= 2003 |pmid= 12409310 |doi= 10.1074/jbc.M201375200 }}
*{{cite journal  | vauthors=Gonzalez-Cabrera PJ, Gaivin RJ, Yun J |title=Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130 |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1104–16 |year= 2003 |pmid= 12695539 |doi=10.1124/mol.63.5.1104 |display-authors=etal}}
*{{cite journal  | author=Diviani D, Lattion AL, Abuin L, ''et al.'' |title=The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19331-40 |year= 2003 |pmid= 12644451 |doi= 10.1074/jbc.M302110200 }}
*{{cite journal  | vauthors=Pupo AS, Minneman KP |title=Specific interactions between gC1qR and alpha1-adrenoceptor subtypes |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2–3 |pages= 185–95 |year= 2004 |pmid= 14626446 |doi=10.1081/RRS-120025200 }}
*{{cite journal  | author=Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, ''et al.'' |title=Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130. |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1104-16 |year= 2003 |pmid= 12695539 |doi=  }}
*{{cite journal  | vauthors=Hague C, Uberti MA, Chen Z |title=Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15541–9 |year= 2004 |pmid= 14736874 |doi= 10.1074/jbc.M314014200 |display-authors=etal}}
*{{cite journal  | author=Pupo AS, Minneman KP |title=Specific interactions between gC1qR and alpha1-adrenoceptor subtypes. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2-3 |pages= 185-95 |year= 2004 |pmid= 14626446 |doi=  }}
*{{cite journal  | vauthors=Kang SK, Yi KS, Kwon NS |title=Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36593–600 |year= 2004 |pmid= 15220331 |doi= 10.1074/jbc.M402084200 |display-authors=etal}}
*{{cite journal  | author=Hague C, Uberti MA, Chen Z, ''et al.'' |title=Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15541-9 |year= 2004 |pmid= 14736874 |doi= 10.1074/jbc.M314014200 }}
*{{cite journal  | vauthors=Gonzalez-Cabrera PJ, Shi T, Yun J |title=Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes |journal=Endocrinology |volume=145 |issue= 11 |pages= 5157–67 |year= 2004 |pmid= 15297446 |doi= 10.1210/en.2004-0728 |display-authors=etal}}
*{{cite journal  | author=Kang SK, Yi KS, Kwon NS, ''et al.'' |title=Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36593-600 |year= 2004 |pmid= 15220331 |doi= 10.1074/jbc.M402084200 }}
*{{cite journal  | vauthors=Zhang T, Xu Q, Chen FR |title=Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors |journal=Acta Pharmacol. Sin. |volume=25 |issue= 11 |pages= 1471–8 |year= 2005 |pmid= 15525470 |doi=  |display-authors=etal}}
*{{cite journal  | author=Gonzalez-Cabrera PJ, Shi T, Yun J, ''et al.'' |title=Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes. |journal=Endocrinology |volume=145 |issue= 11 |pages= 5157-67 |year= 2004 |pmid= 15297446 |doi= 10.1210/en.2004-0728 }}
*{{cite journal  | author=Zhang T, Xu Q, Chen FR, ''et al.'' |title=Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors. |journal=Acta Pharmacol. Sin. |volume=25 |issue= 11 |pages= 1471-8 |year= 2005 |pmid= 15525470 |doi=  }}
}}
{{refend}}
{{refend}}


{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:Adrenergic receptors‎]]
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:Adrenergic receptors]]
{{WS}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 15:31, 4 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.[1]

Ligands

Antagonists

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.[3] A role in regulation of dopaminergic neurotransmission has also been suggested.[4][5]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".
  2. ↑ Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.
  3. ↑ Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.
  4. ↑ Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. PMID 11923452.
  5. ↑ Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162.

External links

Further reading

  • Ramarao CS, Denker JM, Perez DM, et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor". J. Biol. Chem. 267 (30): 21936–45. PMID 1328250.
  • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity" (PDF). Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393.
  • Lomasney JW, Cotecchia S, Lorenz W, et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. PMID 1706716.
  • Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750.
  • Schwinn DA, Johnston GI, Page SO, et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.
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