ADCYAP1R1

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Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Identifiers
Symbols ADCYAP1R1 ; PACAPR; PACAPRI
External IDs Template:OMIM5 Template:MGI HomoloGene: 870
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, also known as ADCYAP1R1 or pituitary adenylate cyclase-activating polypeptide receptor 1 (PACAPR1), is a human gene. This receptor binds pituitary adenylate cyclase activating peptide.[1][2]

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.[3]


References

  1. ↑ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochem. Biophys. Res. Commun. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  2. ↑ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacol. Rev. 52 (2): 269–324. PMID 10835102.
  3. ↑ "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".

Further reading

  • Stoffel M, Espinosa R, Trabb JB; et al. (1995). "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7". Genomics. 23 (3): 697–9. doi:10.1006/geno.1994.1560. PMID 7851900.
  • Ogi K, Miyamoto Y, Masuda Y; et al. (1994). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochem. Biophys. Res. Commun. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  • Ohtaki T, Masuda Y, Ishibashi Y; et al. (1994). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". J. Biol. Chem. 268 (35): 26650–7. PMID 8253796.
  • Pisegna JR, Wank SA (1996). "Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.". J. Biol. Chem. 271 (29): 17267–74. PMID 8663363.
  • Pantaloni C, Brabet P, Bilanges B; et al. (1996). "Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation". J. Biol. Chem. 271 (36): 22146–51. PMID 8703026.
  • Solano RM, Carmena MJ, Carrero I; et al. (1996). "Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate". Endocrinology. 137 (7): 2815–22. PMID 8770902.
  • Wei Y, Mojsov S (1997). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". J. Neuroendocrinol. 8 (11): 811–7. PMID 8933357.
  • Brabet P, Diriong S, Journot L; et al. (1997). "Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization". Genomics. 38 (1): 100–2. doi:10.1006/geno.1996.0600. PMID 8954788.
  • Yon L, Breault L, Contesse V; et al. (1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". J. Clin. Endocrinol. Metab. 83 (4): 1299–305. PMID 9543159.
  • Steinhoff M, McGregor GP, Radleff-Schlimme A; et al. (1999). "Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis". Regul. Pept. 80 (1–2): 49–55. PMID 10235634.
  • Zeng N, Athmann C, Kang T; et al. (1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". J. Clin. Invest. 104 (10): 1383–91. PMID 10562300.
  • Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (2000). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". J. Neuroendocrinol. 11 (12): 941–9. PMID 10583729.
  • Scaldaferri ML, Modesti A, Palumbo C; et al. (2000). "Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta". Endocrinology. 141 (3): 1158–67. PMID 10698193.
  • Busto R, Prieto JC, Bodega G; et al. (2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides. 21 (2): 265–9. PMID 10764955.
  • Knutsson M, Edvinsson L (2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". Neuroreport. 13 (4): 507–9. PMID 11930171.
  • Miampamba M, Germano PM, Arli S; et al. (2002). "Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons". Regul. Pept. 105 (3): 145–54. PMID 11959368.
  • Le SV, Yamaguchi DJ, McArdle CA; et al. (2003). "PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells". Regul. Pept. 109 (1–3): 115–25. PMID 12409223.
  • Ronaldson E, Robertson DN, Johnson MS; et al. (2003). "Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF". Regul. Pept. 109 (1–3): 193–8. PMID 12409233.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Isobe K, Tatsuno I, Yashiro T; et al. (2003). "Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis". Regul. Pept. 110 (3): 213–7. PMID 12573802.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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