Thrombus precursor protein (TpP)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Thrombus precursor protein (TpP), which measures soluble fibrin, is a marker of active thrombosis. Patients with ACS who present early after symptom onset have been shown to have significantly higher levels of TpP as compared to controls [1]. Several smaller studies have evaluated TpP as a diagnostic tool and found that TpP appears to offer useful information for patients with ACS, particularly those patients who presented early after symptom onset [2] [3]

References

  1. Carville DG, Dimitrijevic N, Walsh M, Digirolamo T, Brill EM, Drew N, Gargan PE. Thrombus precursor protein (TpP): marker of thrombosis early in the pathogenesis of myocardial infarction. Clin Chem. 1996 Sep; 42 (9): 1537-41. PMID 8787726
  2. Laurino JP, Pelletier TE, Eadry R, Kounavis A. Thrombus Precursor Protein and the measurement of thrombosis in patients with acute chest pain syndrome. Ann Clin Lab Sci. 1997 Sep-Oct; 27 (5): 338-45. PMID 9303172
  3. Hermens WT, Pelsers MM, Mullers-Boumans ML, de Zwaan C, Glatz JF. Combined use of markers of muscle necrosis and fibrinogen conversion in the early differentiation of myocardial infarction and unstable angina. Clin Chem. 1998 Apr; 44 (4): 890-2. PMID 9554509



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