Interleukin 11

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interleukin 11
Identifiers
Symbol IL11
Entrez 3589
HUGO 5966
OMIM 147681
RefSeq NP_000632
UniProt P20809
Other data
Locus Chr. 19 q13.3-q13.4

Interleukin 11 (IL-11) is a cytokine (first isolated in 1990) that originates from bone marrow stroma and activates B cells and megakaryocytes.[1] It is also known under the names Adipogenesis inhibitory factor (AGIF)[2] and Oprelvekin.

Compared to other interleukins, IL-11 relatively under-characterized.

The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19.[3] IL-11 belongs to the IL-6 superfamily.

Functions

IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones.

References

  1. Paul,S.R., et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proceeding of the National Academy of Science U.S.A., 1990, Volume 87 pages 7512-7516.
  2. Kawashima,I et al., Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Letters, 1991, Volume 283, pages 199-202.
  3. McKinley et al., Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics, 1992, Volume 13, pages 814-819.

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