Tiaprofenic acid

Tiaprofenic acid

File:Tiaprofenic acid.svg
Clinical data
Pregnancy category	C
Routes of administration	oral
ATC code	M01AE11 (WHO)
Legal status
Legal status	POM
Pharmacokinetic data
Bioavailability	90%
Metabolism	10% hepatic
Elimination half-life	1.5-2.5h
Excretion	50-80% urine
Identifiers
IUPAC name 5-Benzoyl-α-methyl-2-thiopheneacetic acid
CAS Number	33005-95-7
PubChem CID	5468
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C14H12O3S
Molar mass	260.309

Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.

It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.

Longterm use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.

It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available.

References

• Crawford MLA, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology 1997; 79(4): 578-584.

External links

• Manufacturer Data Sheet [1]