Thymoma history and symptoms: Difference between revisions
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*Anexity, diarrhea and palpitation (associcated with [[thyroiditis]] and [[ulcerative colitis]]) | *Anexity, diarrhea and palpitation (associcated with [[thyroiditis]] and [[ulcerative colitis]]) | ||
===Lack of symptoms== | ===Lack of symptoms=== | ||
33% to 50% of patients with thymoma have no symptoms at all, and the mass is identified on a [[chest X-ray]] performed for an unrelated problem.<ref name="pmid10561285">{{cite journal |author=Thomas CR, Wright CD, Loehrer PJ |title=Thymoma: state of the art |journal=[[Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology]] |volume=17 |issue=7 |pages=2280–9 |year=1999 |month=July |pmid=10561285 |doi= |url=http://www.jco.org/cgi/pmidlookup?view=long&pmid=10561285 |accessdate=2012-01-18}}</ref> | 33% to 50% of patients with thymoma have no symptoms at all, and the mass is identified on a [[chest X-ray]] performed for an unrelated problem.<ref name="pmid10561285">{{cite journal |author=Thomas CR, Wright CD, Loehrer PJ |title=Thymoma: state of the art |journal=[[Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology]] |volume=17 |issue=7 |pages=2280–9 |year=1999 |month=July |pmid=10561285 |doi= |url=http://www.jco.org/cgi/pmidlookup?view=long&pmid=10561285 |accessdate=2012-01-18}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]
Overview
Signs and symptoms
30% of patients with a thymoma have symptoms caused by compression of the surrounding organs, these symptoms may include:[1]
- Facial swelling (due to compression of the upper caval vein)
- Dysphagia (due to compression of the esophagus)
- Cough and wheezing (due to compression of the trachea)
- Chest pain (due to local compression of the mass itself)
30% of patients have their tumors discovered because they have an associated autoimmune disorder, these symptoms may inculde:
- Muscle weakness (associated with myasthenia gravis and polymyositis)
- Anemia (associated with pure red cell aplasia)
- Fever, chest pain, cough and malaise (associated with Good's syndrome, agranulocytosis, combined immunodeficiency, hypogammaglobulinemia and acute pericarditis) )
- Arthralgia and rash (associated with polymyositis, scleroderma, rheumatoid arthritis and systemic lupus erythematosus)
- Anexity, diarrhea and palpitation (associcated with thyroiditis and ulcerative colitis)
Lack of symptoms
33% to 50% of patients with thymoma have no symptoms at all, and the mass is identified on a chest X-ray performed for an unrelated problem.[1]
| Type | Diseases |
| Neuromuscular Diseases | Myasthenia gravis, neuromyotonia, rippling muscle disease, polymyositis/dermatomyositis, encephalitis (limbic, cortical and brain stem), intestinal pseudoobstruction. |
| Haematologic Autoimmune Diseases | Anemia: pure red cell aplasia, pernicious anemia, hemolytic anemia and aplastic anemia. Other isolated cytopenis: esinophils, basophils and neutrophils. Immunodeficiencies: hypogammaglobulinaemia +/- T-cell deficiencies (Good syndrome). |
| Dermatologic Diseases | Pemphigus (foliaceus or paraneoplastic), lichen planus, alopecia areata. |
| Endocrine Disorders | Addison disease, graves disease and Cushing disease. |
| Renal and Hepatic Diseases | Glomerulonephritis and autoimmune hepatitis. |
| Systemic Autoimmune Diseases | SLE, Sjögren syndrome, systemic sclerosis and graft-versus-host-disease. |
References
- ↑ 1.0 1.1 Thomas CR, Wright CD, Loehrer PJ (1999). "Thymoma: state of the art". Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17 (7): 2280–9. PMID 10561285. Retrieved 2012-01-18. Unknown parameter
|month=ignored (help) - ↑ "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). External link in
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