Pacemaker syndrome differential diagnosis

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Differentiating Pacemaker syndrome from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

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Differentiating Pacemaker syndrome from other Diseases

Patients with pacemaker syndrome present with varied symptoms resulting from dyssynchrony between atria and ventricles. Major presenting symptoms include:

  • Symptoms of low cardiac output like weakness, fatigue, lightheadedness and dyspnea on exertion


Pacemaker syndrome should be differentiated from the following diseases:

  • Acute coronary syndrome
  • Failed pacemaker
  • Hypothyroidism
  • Cardiogenic pulmonary edema
  • Arrhythmias (especially supraventricular tachycardias)
  • Hyperthyroidism
  • Pulmonary embolism
  • Carotid sinus hypersensitivity

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