POEMS syndrome history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{POEMS syndrome}} | {{POEMS syndrome}} | ||
{{CMG}} | {{CMG}} {{AE}} {{HK}} | ||
== Overview == | == Overview == | ||
Patients suffering from POEMS syndrome may have variable presentation and can present a diagnostic challenge for the clinician due to non-specific | Patients suffering from POEMS syndrome may have variable presentation and can present a diagnostic challenge for the clinician due to non-specific symptomology. Common [[symptoms]] of POEMS syndrome include [[numbness]], [[Paresthesia|tingling]] and weakness affecting extremities, [[fatigue]], generalized pain in the body, [[foot drop]], [[blurred vision]], [[peripheral edema]], [[dyspnea]] and [[hyperpigmentation]]. Less common [[symptoms]] include [[muscle weakness]], [[diplopia]], [[ocular]] pain and [[ascites]]. | ||
== History == | == History and Symptoms == | ||
== | === History === | ||
Patients suffering from POEMS syndrome may have variable | |||
* [[Patient|Patients]] suffering from POEMS syndrome may have variable clinical presentations due to multi-system involvement. | |||
* The [[median]] time from onset of [[symptoms]] to [[diagnosis]] of POEMS is 13 to 18 months.<ref name="pmid12456500">{{cite journal |vauthors=Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, Greipp PR, Witzig TE, Basu R, Suarez GA, Fonseca R, Lust JA, Gertz MA |title=POEMS syndrome: definitions and long-term outcome |journal=Blood |volume=101 |issue=7 |pages=2496–506 |date=April 2003 |pmid=12456500 |doi=10.1182/blood-2002-07-2299 |url=}}</ref><ref name="pmid21221584">{{cite journal |vauthors=Li J, Zhou DB, Huang Z, Jiao L, Duan MH, Zhang W, Zhao YQ, Shen T |title=Clinical characteristics and long-term outcome of patients with POEMS syndrome in China |journal=Ann. Hematol. |volume=90 |issue=7 |pages=819–26 |date=July 2011 |pmid=21221584 |doi=10.1007/s00277-010-1149-0 |url=}}</ref> | |||
* Presence of a combination of [[peripheral neuropathy]], and [[Monoclonal gammopathy|monoclonal]] protein, particularly a lambda-restricted [[monoclonal gammopathy]] should raise the suspicion of POEMS syndrome. | |||
=== Common Symptoms === | === Common Symptoms === | ||
Common symptoms of POEMS syndrome include the following:<ref name="pmid24532337">{{cite journal |vauthors=Dispenzieri A |title=POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=2 |pages=214–23 |date=February 2014 |pmid=24532337 |doi=10.1002/ajh.23644 |url=}}</ref><ref name="pmid24624542">{{cite journal |vauthors=Dispenzieri A, Buadi FK |title=A review of POEMS syndrome |journal=Oncology (Williston Park, N.Y.) |volume=27 |issue=12 |pages=1242–50 |date=December 2013 |pmid=24624542 |doi= |url=}}</ref> | Common [[symptoms]] of POEMS syndrome include the following:<ref name="pmid24532337">{{cite journal |vauthors=Dispenzieri A |title=POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=2 |pages=214–23 |date=February 2014 |pmid=24532337 |doi=10.1002/ajh.23644 |url=}}</ref><ref name="pmid24624542">{{cite journal |vauthors=Dispenzieri A, Buadi FK |title=A review of POEMS syndrome |journal=Oncology (Williston Park, N.Y.) |volume=27 |issue=12 |pages=1242–50 |date=December 2013 |pmid=24624542 |doi= |url=}}</ref><ref name="pmid23811954">{{cite journal |vauthors=Cui RT, Yu SY, Huang XS, Zhang JT, Li F, Pu CQ |title=The characteristics of ascites in patients with POEMS syndrome |journal=Ann. Hematol. |volume=92 |issue=12 |pages=1661–4 |date=December 2013 |pmid=23811954 |doi=10.1007/s00277-013-1829-7 |url=}}</ref><ref name="pmid6248720">{{cite journal |vauthors=Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL |title=Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature |journal=Medicine (Baltimore) |volume=59 |issue=4 |pages=311–22 |date=July 1980 |pmid=6248720 |doi= |url=}}</ref><ref name="pmid23557151">{{cite journal |vauthors=Miest RY, Comfere NI, Dispenzieri A, Lohse CM, el-Azhary RA |title=Cutaneous manifestations in patients with POEMS syndrome |journal=Int. J. Dermatol. |volume=52 |issue=11 |pages=1349–56 |date=November 2013 |pmid=23557151 |doi=10.1111/j.1365-4632.2012.05648.x |url=}}</ref><ref name="pmid24141729">{{cite journal |vauthors=Cui R, Yu S, Huang X, Zhang J, Tian C, Pu C |title=Papilloedema is an independent prognostic factor for POEMS syndrome |journal=J. Neurol. |volume=261 |issue=1 |pages=60–5 |date=January 2014 |pmid=24141729 |doi=10.1007/s00415-013-7143-4 |url=}}</ref> | ||
* Numbness, tingling and weakness in the feet, later affecting the legs and hands | * [[Numbness]], [[tingling]] and weakness in the feet, later affecting the legs and hands | ||
* Fatigue | * [[Fatigue]] | ||
* Generalized pain | * Generalized pain | ||
* Foot drop | * [[Foot drop]] | ||
* Blurred vision | * [[Blurred vision]] | ||
* Peripheral edema | * [[Peripheral edema]] | ||
* Dyspnea | * [[Dyspnea]] | ||
* Hyperpigmentation | * [[Hyperpigmentation]] | ||
* [[Clubbing]] | |||
=== Less Common Symptoms === | === Less Common Symptoms === | ||
Less common | Less common [[symptoms]] of POEMS syndrome include the following:<ref name="pmid7985714">{{cite journal |vauthors=Soubrier MJ, Dubost JJ, Sauvezie BJ |title=POEMS syndrome: a study of 25 cases and a review of the literature. French Study Group on POEMS Syndrome |journal=Am. J. Med. |volume=97 |issue=6 |pages=543–53 |date=December 1994 |pmid=7985714 |doi= |url=}}</ref><ref name="urlPOEMS Syndrome - NORD (National Organization for Rare Disorders)">{{cite web |url=https://rarediseases.org/rare-diseases/poems-syndrome/ |title=POEMS Syndrome - NORD (National Organization for Rare Disorders) |format= |work= |accessdate=}}</ref> | ||
* Muscle weakness | * [[Muscle weakness]] | ||
* Diplopia | * [[Diplopia]] | ||
* Ocular pain | * [[Ocular]] pain | ||
* Ascites | * [[Ascites]] | ||
* Erectile dysfunction | * [[Erectile dysfunction]] | ||
* [[Gynecomastia]] | |||
* [[Amenorrhea]] | |||
==References== | ==References== | ||
Latest revision as of 14:02, 9 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Patients suffering from POEMS syndrome may have variable presentation and can present a diagnostic challenge for the clinician due to non-specific symptomology. Common symptoms of POEMS syndrome include numbness, tingling and weakness affecting extremities, fatigue, generalized pain in the body, foot drop, blurred vision, peripheral edema, dyspnea and hyperpigmentation. Less common symptoms include muscle weakness, diplopia, ocular pain and ascites.
History and Symptoms
History
- Patients suffering from POEMS syndrome may have variable clinical presentations due to multi-system involvement.
- The median time from onset of symptoms to diagnosis of POEMS is 13 to 18 months.[1][2]
- Presence of a combination of peripheral neuropathy, and monoclonal protein, particularly a lambda-restricted monoclonal gammopathy should raise the suspicion of POEMS syndrome.
Common Symptoms
Common symptoms of POEMS syndrome include the following:[3][4][5][6][7][8]
- Numbness, tingling and weakness in the feet, later affecting the legs and hands
- Fatigue
- Generalized pain
- Foot drop
- Blurred vision
- Peripheral edema
- Dyspnea
- Hyperpigmentation
- Clubbing
Less Common Symptoms
Less common symptoms of POEMS syndrome include the following:[9][10]
References
- ↑ Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, Greipp PR, Witzig TE, Basu R, Suarez GA, Fonseca R, Lust JA, Gertz MA (April 2003). "POEMS syndrome: definitions and long-term outcome". Blood. 101 (7): 2496–506. doi:10.1182/blood-2002-07-2299. PMID 12456500.
- ↑ Li J, Zhou DB, Huang Z, Jiao L, Duan MH, Zhang W, Zhao YQ, Shen T (July 2011). "Clinical characteristics and long-term outcome of patients with POEMS syndrome in China". Ann. Hematol. 90 (7): 819–26. doi:10.1007/s00277-010-1149-0. PMID 21221584.
- ↑ Dispenzieri A (February 2014). "POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 89 (2): 214–23. doi:10.1002/ajh.23644. PMID 24532337.
- ↑ Dispenzieri A, Buadi FK (December 2013). "A review of POEMS syndrome". Oncology (Williston Park, N.Y.). 27 (12): 1242–50. PMID 24624542.
- ↑ Cui RT, Yu SY, Huang XS, Zhang JT, Li F, Pu CQ (December 2013). "The characteristics of ascites in patients with POEMS syndrome". Ann. Hematol. 92 (12): 1661–4. doi:10.1007/s00277-013-1829-7. PMID 23811954.
- ↑ Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL (July 1980). "Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature". Medicine (Baltimore). 59 (4): 311–22. PMID 6248720.
- ↑ Miest RY, Comfere NI, Dispenzieri A, Lohse CM, el-Azhary RA (November 2013). "Cutaneous manifestations in patients with POEMS syndrome". Int. J. Dermatol. 52 (11): 1349–56. doi:10.1111/j.1365-4632.2012.05648.x. PMID 23557151.
- ↑ Cui R, Yu S, Huang X, Zhang J, Tian C, Pu C (January 2014). "Papilloedema is an independent prognostic factor for POEMS syndrome". J. Neurol. 261 (1): 60–5. doi:10.1007/s00415-013-7143-4. PMID 24141729.
- ↑ Soubrier MJ, Dubost JJ, Sauvezie BJ (December 1994). "POEMS syndrome: a study of 25 cases and a review of the literature. French Study Group on POEMS Syndrome". Am. J. Med. 97 (6): 543–53. PMID 7985714.
- ↑ "POEMS Syndrome - NORD (National Organization for Rare Disorders)".