Noonan syndrome: Difference between revisions

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	Noonan syndrome;
	A 12-year-old girl with Noonan syndrome. Note the typical webbed neck and the severe scoliosis.
ICD-10	Q87.1
ICD-9	759.89
OMIM	163950
DiseasesDB	29094
MedlinePlus	001656
MeSH	D009634

VisualWikitext

Revision as of 14:22, 20 August 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Scott Williams

For patient information click here

Overview

Noonan Syndrome (NS) is a relatively common congenital genetic condition which affects both males and females. It used to be referred to as the male version of Turner's syndrome^[1]; however, the genetic causes of Noonan syndrome and Turner syndrome are distinct. The principal features include congenital heart malformation, short stature, learning problems, indentation of the chest, impaired blood clotting, and a characteristic configuration of facial features. The syndrome is named after Dr Jacqueline Noonan.

It is believed that between approximately 1 in 1,000 and 1 in 2,500 children worldwide are born with NS. It is one of the most common genetic syndromes associated with congenital heart disease, similar in frequency to Down syndrome. However, the range and severity of features can vary greatly in patients with NS. Therefore, the syndrome is not always identified at an early age.

History

Jacqueline Noonan was practicing as a pediatric cardiologist at the University of Iowa when she noticed that children with a rare type of heart defect, valvular pulmonary stenosis, often had a characteristic physical appearance with short stature, webbed neck, wide spaced eyes, and low-set ears. Both boys and girls were affected. Even though these characteristics were sometimes seen running in families, chromosomes appeared grossly normal. She studied 833 patients at the congenital heart disease clinic, looking for other congenital abnormalities, and in 1962 presented a paper: "Associated non-cardiac malformations in children with congenital heart disease". This described 9 children who in addition to congenital heart disease had characteristic faces, chest deformities and short stature. Both males and females were found to be similarly affected, and the chromosomes were apparently normal.

Dr John Opitz, a former student of Dr Noonan, first began to call the condition "Noonan Syndrome" when he saw children who looked like those whom Dr Noonan had described. Dr Noonan later produced a paper entitled "Hypertelorism with Turner Phenotype", and in 1971 at the Symposium of Cardiovascular defects, the name 'Noonan Syndrome' became officially recognized.

Pathophysiology

NS may be inherited in an autosomal dominant pattern with variable expression.

Recurrence in siblings and apparent transmission from parent to child has long suggested a genetic defect with autosomal dominant inheritance and variable expression. A person with NS has up to a 50% chance of transmitting it to a child. The fact that an affected parent is not always identified for children with NS suggests several possibilities:

a parent could carry the gene without being affected (incomplete penetrance)
manifestations are variably expressed and could be so subtle as to go unrecognized (variable expressivity)
a high proportion of cases represent new, sporadic mutations or
Noonan syndrome is heterogeneous, comprising more than one similar condition of differing cause, some not inherited.

In most of the families with multiple affected members, NS maps to chromosome 12q24.1. In 2001, it was reported that approximately half of a group of patients with Noonan syndrome carried a mutation of the PTPN11 gene at that location, which encodes protein tyrosine phosphatase SHP-2.^[2] The SHP2 protein is a component of several intracellular signal transduction pathways involved in embryonic development that modulate cell division, differentiation, and migration, including that mediated by the epidermal growth factor receptor. The latter pathway is important in the formation of the cardiac semilunar valves. It has recently been shown that activating mutations in SOS1 also give rise to NS.^[3] Shp2 and SOS1 both have roles as positive regulators of the Ras/MAP kinase pathway suggesting that dysregulation of this pathway may play a major role in the genesis of this syndrome.^[4] Additional mutations in KRAS ^[5] and RAF1^[6] genes have been reported to cause Noonan syndrome in a smaller percentage of individuals with the syndrome. Chromosomal abnormalities, such as a duplication of chromosome region 12q24 encompassing gene PTPN11 can result in an apparent Noonan syndrome^[7].

Manifestations by organ system

The most prevalent (common) signs are highlighted in bold with frequency listed in parentheses.

Cardiac

2/3 of patients have a heart defect

Pulmonary Valvular Stenosis —(50%)
Septal defects: atrial —(10%) or ventricular —(less common)
Heart murmur
Cardiomyopathy

Gastrointestinal System

Failure to thrive as an infant
Decreased appetite
Digestive problems
Frequent or forceful vomiting
Swallowing difficulties

Genito-Urinary System

Cryptorchidism (undescended testicles) — (almost all males)

Lymphatic System

Posterior cervical Hygroma (webbed neck)
Lymphedema (build-up of body fluid due to poor functioning of the lymphatic system)

Developmental

Clumsiness
Poor coordination
Motor delay
Mental retardation —(1/3 of patients have mild MR)
Learning disabilities

Speech and language delays

Musculoskeletal

Some patients with Noonan Syndrome suffer from severe joint pain or muscle pain often with no identifiable cause

Hematologic

Easy bruising
Amegakaryocytic Thrombocytopenia (low platelet count)
Blood Clotting Disorders
Von Willebrand disease
Prolonged activated partial thromboplastin time
Partial deficiency of Factor VIII:C
Partial deficiency of Factor XI:C
Partial deficiency of Factor XII:C
Combined Coagulation deficiencies

Neurological

Arnold Chiari Malformation (Type 1) has been noted in some patients with Noonan Syndrome

Diagnosis

Despite identification of four causative genes, the diagnosis of Noonan syndrome is still based on clinical features. In other words, it is made when a physician feels that a patient has enough of the features to warrant the label indicating association. The patient can be tested for mutations in the PTPN11, SOS1, or KRAS genes, however absence of a mutation will not exclude the diagnosis as there are more as yet undiscovered genes that cause NS. The principal values of making such a diagnosis are that it guides additional medical and developmental evaluations, it excludes other possible explanations for the features, and it allows more accurate recurrence risk estimates.

Physical Examination

STATURE/POSTURE

Short stature

Cervical (neck) spine fusion

Scoliosis

Prominence of breast bone (pectus carinatum)

Depression of breast bone (pectus excavatum)

Joint contractures or tightness

Joint hyperextensibility or looseness

Growth retardation

Winging of the scapula

Hypotonia (low muscle tone)

HEAD

Excess skin on the back of the neck

Low hairline at the nape of the neck

Large head

Triangular face shape

Broad forehead

Short neck, webbed neck, posterior cervical

Curly hair

EYES

Widely set eyes (hypertelorism) —(95%)

Drooping of the eyelids (ptosis (eyelid))

Epicanthal folds (extra fold of skin at the inner corner of the eye)

Proptosis (bulging eyes)

Refractive visual errors

Inward or outward turning of the eyes (strabismus)

Nystagmus - jerking movement of the eyes

NOSE

Small, upturned nose

EARS/HEARING

Low set ears —(over 90%)

Backward rotated ears —(over 90%)

Thick helix of ear (outer rim) —(over 90%)

Incomplete folding of ears

Chronic Otitis media (ear infections)

MOUTH/SPEECH

Deeply grooved philtrum (top lip line) —(over 90%)

Micrognathia (undersized lower jaw)

High Arched palate

Dental problems

Articulation Difficulties

Poor tongue control

LIMBS/EXTREMITIES

Bluntly ended fingers

Extra padding on fingers and toes

Edema of the back of hands and tops of feet

Cubitus valgus (elbow deformity: with abnormal turning-in)

SKIN

Lymphedema (swelling of the extremities)

Keloids (scar hypertrophy)

Hyperkeratosis - overdevelopment of outer skin layer

Pigmented nevi (birthmark)

References

↑ Curcić-Stojković O, Nikolić L, Obradović D, Krstić A, Radić A (1978). "[Noonan's syndrome. (Male Turner's syndrome, Turner-like syndrome)]". Med Pregl. 31 (7–8): 299–303. PMID 692497.
↑ Tartaglia M, Mehler EL, Goldberg R; et al. (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759.
↑ Roberts AE, Araki T, Swanson KD; et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
↑ Bentires-Alj M, Kontaridis MI, Neel BG (2006). "Stops along the RAS pathway in human genetic disease". Nat. Med. 12 (3): 283–5. doi:10.1038/nm0306-283. PMID 16520774.
↑ Schubbert S, Zenker M, Rowe SL; et al. (2006). "Germline KRAS mutations cause Noonan syndrome". Nat. Genet. 38 (3): 331–6. doi:10.1038/ng1748. PMID 16474405.
↑ Razzaque MA, Nishizawa T, Komoike Y; et al. (2007). "Germline gain-of-function mutations in RAF1 cause Noonan syndrome". Nat. Genet. 39 (8): 1013–7. doi:10.1038/ng2078. PMID 17603482.
↑ Shchelochkov OA et al, Am J Med Genet A, 2008 Apr 15;146A(8):1042-8
↑ CDC. (2004). Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis. Can be downloaded at http://www.cdc.gov/fas/faspub.htm.

External links

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[1] Curcić-Stojković O, Nikolić L, Obradović D, Krstić A, Radić A (1978). "[Noonan's syndrome. (Male Turner's syndrome, Turner-like syndrome)]". Med Pregl. 31 (7–8): 299–303. PMID 692497.

[2] Tartaglia M, Mehler EL, Goldberg R; et al. (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759.

[3] Roberts AE, Araki T, Swanson KD; et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.

[4] Bentires-Alj M, Kontaridis MI, Neel BG (2006). "Stops along the RAS pathway in human genetic disease". Nat. Med. 12 (3): 283–5. doi:10.1038/nm0306-283. PMID 16520774.

[5] Schubbert S, Zenker M, Rowe SL; et al. (2006). "Germline KRAS mutations cause Noonan syndrome". Nat. Genet. 38 (3): 331–6. doi:10.1038/ng1748. PMID 16474405.

[6] Razzaque MA, Nishizawa T, Komoike Y; et al. (2007). "Germline gain-of-function mutations in RAF1 cause Noonan syndrome". Nat. Genet. 39 (8): 1013–7. doi:10.1038/ng2078. PMID 17603482.

[7] Shchelochkov OA et al, Am J Med Genet A, 2008 Apr 15;146A(8):1042-8

[8] CDC. (2004). Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis. Can be downloaded at http://www.cdc.gov/fas/faspub.htm.

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