Non-Hodgkin lymphoma (differentiating types of NHL)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Non-Hodgkin lymphoma (differentiating types of NHL)
Differentiating different types of Non-Hodgkin lymphoma. Gold standard for differentiation different types of Non-Hodgkin lymphoma is Biopsy.
Category | Disease | Etiology | Clinical manifestations | Paraclinical findings | Associated findings | ||||||||||
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Lab findings | |||||||||||||||
Symptoms | Signs | CBC | Immunochemistry | Histopathology | |||||||||||
Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | |||||||
Hodgkin's Lymphoma[1][2][3][4][5] |
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- | ± | - |
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Non-Hodgkin's Lymphoma | |||||||||||||||
Diffuse large B cell lymphoma[6][7][8][9][10][11]. |
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- | + | + |
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↓ | ↓ | Nl to ↓ |
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Centroblastic
Immunoblastic
Anaplastic
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B Cell Lymphoma | Mantle cell lymphoma |
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Abdominal distention |
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↓ | Nl to ↓ |
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B-lymphoblastic leukemia/lymphoma |
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+ | – | – | – |
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↓ | ↓ | Nl to ↓ |
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Follicular lymphoma |
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Only in 20% of patients: | + | + | ± |
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↓ | ↓ | Nl to ↓ |
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Burkitt lymphoma |
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B cell chronic lymphocytic leukemia/small lymphocytic lymphoma |
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Marginal zone lymphoma | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type |
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Splenic marginal zone lymphoma |
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Nodal marginal zone B-cell lymphoma |
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+ |
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Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia) |
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Hairy cell leukemia |
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Category | Disease | Etiology | Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | Immunochemistry | Histopathology | Associated findings | |
T cell lymphoma | Precursor T-cell lymphoblastic leukemia/lymphoma |
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Adult T cell leukemia/lymphoma |
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Anaplastic large cell lymphoma |
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Cutaneous T-cell lymphoma | Mycosis fungoides / Sézary syndrome |
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Peripheral T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
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Hepatosplenic gamma-delta T-cell lymphoma |
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Enteropathy-type intestinal T-cell lymphoma |
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Extranodal T-cell lymphoma, nasal type |
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Angioimmunoblastic T-cell lymphoma |
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Peripheral T-cell lymphoma, unspecified |
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- ↑ Mauch PM, Kalish LA, Kadin M, Coleman CN, Osteen R, Hellman S (March 1993). "Patterns of presentation of Hodgkin disease. Implications for etiology and pathogenesis". Cancer. 71 (6): 2062–71. PMID 8443755.
- ↑ Gobbi PG, Cavalli C, Gendarini A, Crema A, Ricevuti G, Federico M, Di Prisco U, Ascari E (December 1985). "Reevaluation of prognostic significance of symptoms in Hodgkin's disease". Cancer. 56 (12): 2874–80. PMID 4052959.
- ↑ Buri C, Körner M, Schärli P, Cefai D, Uguccioni M, Mueller C, Laissue JA, Mazzucchelli L (March 2001). "CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease". Blood. 97 (6): 1543–8. PMID 11238088.
- ↑ Peh SC, Looi LM, Pallesen G (March 1997). "Epstein-Barr virus (EBV) and Hodgkin's disease in a multi-ethnic population in Malaysia". Histopathology. 30 (3): 227–33. PMID 9088951.
- ↑ Andriko JA, Aguilera NS, Nandedkar MA, Abbondanzo SL (April 1997). "Childhood Hodgkin's disease in the United States: an analysis of histologic subtypes and association with Epstein-Barr virus". Mod. Pathol. 10 (4): 366–71. PMID 9110300.
- ↑ Colomo, L.; López-Guillermo, A; Perales, M; Rives, S; Martínez, A; Bosch, F; Colomer, D; Falini, B; Montserrat, E; Campo, E (2002). "Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma". Blood. 101 (1): 78–84. doi:10.1182/blood-2002-04-1286. PMID 12393466.
- ↑ Hans, C. P.; Weisenburger, D. D.; Greiner, T. C.; Gascoyne, R. D.; Delabie, J; Ott, G; Müller-Hermelink, H. K.; Campo, E; Braziel, R. M.; Jaffe, E. S.; Pan, Z; Farinha, P; Smith, L. M.; Falini, B; Banham, A. H.; Rosenwald, A; Staudt, L. M.; Connors, J. M.; Armitage, J. O.; Chan, W. C. (2004). "Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray". Blood. 103 (1): 275–82. doi:10.1182/blood-2003-05-1545. PMID 14504078.
- ↑ Muris, JJF; Meijer, Cjlm; Vos, W; Van Krieken, Jhjm; Jiwa, NM; Ossenkoppele, GJ; Oudejans, JJ (2006). "Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma". The Journal of Pathology. 208 (5): 714–23. doi:10.1002/path.1924. PMID 16400625.
- ↑ Korkolopoulou P, Vassilakopoulos T, Milionis V, Ioannou M (2016). "Recent Advances in Aggressive Large B-cell Lymphomas: A Comprehensive Review". Adv Anat Pathol. 23 (4): 202–43. doi:10.1097/PAP.0000000000000117. PMID 27271843.
- ↑ Swerdlow SH, et al (editors). WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edition. 2008. International Agency for Research on Cancer (IARC), Lyon, Franc
- ↑ Tilly H, et al. Diffuse large B-cell lymphoma (DLBCL): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2015; 26: v116-v125