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==Overview==
==Overview==
Neuroblastoma is a malignant tumor that arises from [[neural crest]] cells, which are normally involved in the development of the [[sympathetic nervous system]] and [[adrenal gland]]s. In 1910, the term neuroblastoma was first used to describe the tumor by Dr. James Homer Wright, an American patholgist at Massachusetts General Hospital. Based on the degree of the cellular maturity and composition, neuroblastoma may be further classified into three subtypes according to the International Neuroblastoma Pathology Classification which include undifferentiated neruoblastoma, poorly differentiated neuroblastoma, and differentiating neuroblastoma. Genes involved in the pathogenesis of neuroblastoma include ''NBPF10'' gene, ''KIF1B'' [[gene]], and ''ALK'' gene. Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. The staging of neuroblastoma is based on the International Neuroblastoma Staging System (INSS). Symptoms of neuroblastoma include fever, abdominal distension, constipation, cough, and weakness. A positive finding of a palpable [[abdominal mass]], [[fever]], and purple skin patches is suggestive of neuroblastoma. On labrotary studies an elevated levels of blood and urinary [[catecholamine]]s, [[vanillylmandelic acid]] (VMA), and [[homovanillic acid]] (HVA) are suggestive of neuroblastoma. CT scan is the investigation of choice for the diagnosis of neuroblastoma. On CT scan, neuroblastoma is characterized by a heterogeneous, calcified, and [[necrotic]] mass, that may encase surrounding [[vessel]]s or invade surrounding tissues. The definitive diagnosis of nueroblastoma is confirmed by a biopsy. Children Oncology Group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. Low risk neuroblastoma patients are usually managed with either observation or [[surgical resection]] of the [[tumor]]. Intermidiate risk neuroblastoma patients are usually managed with [[neoadjuvant chemotherapy]] in advance of a definitive surgical resection. Whereas high risk neuroblastoma patients are usually managed with a combination of surgery, chemotherapy, radiation therapy, [[hematopoietic]] [[stem cell]] [[transplantation]], differentiation therapy, and [[immunotherapy]]. Surgical intervention alone may be curative as a single therapeutic modality for the management of '''low risk''' neuroblastoma patients.
Neuroblastoma is the most common solid extracranial [[cancer]] in [[childhood]] and is the most common [[cancer]] in [[Infant|infancy]]. It is a [[malignant tumor]] that arises from [[neural crest cells]], which are normally involved in the development of the [[sympathetic nervous system]] and [[adrenal gland]]s. It is usually located along the [[sympathetic nervous system]] structures including; [[Adrenal gland|adrenal glands]], [[Retroperitoneal|retroperitoneal organs]], [[Sympathetic chain|paravertebral sympathetic chain]], [[Organ of Zuckerkandl|organ of zuckerkandl]] and [[posterior mediastinum]]. It was first described by Rudolf Virchow in 1864 as an [[abdominal]] [[tumor]] in a [[child]] as "[[glioma]]". James Homer Wright in 1910, described circular clumps of [[bone marrow]] (now named Homer-Wright pseudorosettes) and advanced the understanding that [[tumor]] originated from primitive [[Neuron|neural cells]] and could [[Metastasis|metastasize]] to [[bone]]. International neuroblastoma [[pathology]] [[classification]] system is used for the [[classification]] of neuroblastoma [[Tumor|tumors]], which divides it into 02 main categories based on [[Morphology|morphologic features]] of neuroblastoma [[Tumor|tumors]] into: schwannian stroma poor and schwannian stroma rich/dominant. Neuroblastoma [[tumor]] [[Cell (biology)|cells]] secrete [[catecholamine]] by products including [[Vanillylmandelic acid|vanillylmandelic acid (VMA)]] and [[Homovanillic acid|homovanillic acid (HVA)]] and [[Vasoactive intestinal peptide|vasoactive intestinal polypeptide (VIP)]] [[hormone]] as well. The various genes involved in [[pathogenesis]] of neuroblastoma include; [[NBPF10]], [[KIF1B]], ALK, [[LMO1]] and [[PHOX2A]] [[Gene|genes]]. The most common [[genetic mutation]] is [[Gain-of-function mutation|gain]] of [[Chromosome 17|chromosome 17q]] and MYCN [[oncogene]] [[amplification]] predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of [[Syndrome|syndromes]] including; [[neurofibromatosis type 1]], [[Beckwith-Wiedemann syndrome|beckwith-weidemann syndrome]] and [[Hirschsprung's disease|hirschsprung disease]]. On [[gross pathology]], the characteristic finding of neuroblastoma is a well defined, bulky and tan colored [[mass]], that can be associated with fibrous pseudocapsule, [[necrosis]] or [[hemorrhage]]. On [[Microscopy|microscopic picture]], the presence of round blue [[Cell (biology)|cells]] separated by thin [[fibrous]] [[septa]] are a characteristic finding. There are no known established causes for neuroblastoma. The risk factors for neuroblastomas diagnosed during [[Infant|infancy]] include; [[maternal]] [[anemia]] during [[pregnancy]], [[neonatal respiratory distress syndrome]] and low 1 minute [[Apgar score]]. However, the risk factors for neuroblastoma cases diagnosed at [[age]] 1 year or above is not known. The overall incidence is 4.9 per 1,000,000 individuals in united states. [[Male|Males]] are slightly more affected than [[Female|females]] with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian race. Intra-abdominal neuroblastoma must be differentiated from other [[Disease|diseases]] that cause [[abdominal distension]] and [[constipation]] such as [[Wilms' tumor|Wilms tumor]] and [[ganglioneuroma]]. Intra-thoracic neuroblastoma must be differentiated from other [[Disease|diseases]] that cause [[shortness of breath]] and [[chronic cough]] such as [[intrathoracic]] [[lymphoma]] and extra lobar [[pulmonary]] sequestration. There are no routine [[Screening test|screening tests]] for neuroblastoma due to lack of any [[mortality]] benefits. Neuroblastoma may progress to develop [[fatigue]], [[loss of appetite]], [[joint pain]] and [[fever]] if left untreated. There is gradual development of site specific [[Symptom|symptoms]] as the [[tumor]] size gradually increases. [[Complication (medicine)|Complications]] of neuroblastoma include; [[Diarrhea|persistent refractory diarrhea]], [[horner's syndrome]], [[hypertension]], [[Transverse myelitis|transverse myelopathy]], [[anemia]] and [[Immunodeficiency|suppressed immunity]]. The [[prognosis]] of neuroblastoma is generally regarded as poor, depending on the [[tumor]] extent at the time of [[diagnosis]]. The other [[Prognosis|prognostic factors]] for nuroblastoma include; [[Patient|patient's]] [[age]], [[tumor]] stage and grade, [[genetic mutations]] and response to treatment. According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the [[tumor]] size, [[lymph node]] involvement, and presence of [[metastasis]]. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma [[Patient|patients]] are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the [[tumor]] INSS stage, the [[Patient|patient's]] [[age]], [[tumor]] grade, and the [[amplification]] of MYCN [[gene]]. General neuroblastoma [[Symptom|symptoms]] include; [[fever]], [[irritability]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Other [[Symptom|symptoms]] depending upon the [[anatomical]] location of neuroblastoma include; [[abdominal pain]], [[Abdominal distension|distension]] and [[constipation]] ([[abdomen]]), [[shortness of breath]], [[chronic cough]] & [[difficulty swallowing]] ([[posterior mediastinum]]), [[weakness]], [[numbness]], [[paralysis]] ([[retroperitoneum]]), [[visual]] defects, facial [[bruising]] ([[Head and neck anatomy|head & neck]]) and [[pallor]], [[bone pain]] ([[bone marrow]] [[Metastasis|metastases]]). [[Physical examination]] findings of neuroblastoma include; [[fever]], [[hypertension]], [[tachycardia]], [[pallor]], [[ecchymoses]], [[nystagmus]], [[proptosis]], [[ptosis]], [[abdominal mass]], [[Hyperreflexia|brisk reflexes]], [[sensory loss]] and [[ataxia]]. The laboratory findings in neuroblastoma include; ↓ [[hemoglobin]], ↑ [[ferritin]], ↑ [[catecholamine]], ↑ [[dopamine]], ↑ [[Vanillylmandelic acid|vanillylmandelic acid (VMA)]], ↑ [[Homovanillic acid|homovanillic acid (HVA)]], ↑ [[lactate dehydrogenase]] and ↑ [[neuron-specific enolase]] levels. There are increased [[urinary]] [[catecholamine]], [[Vanillylmandelic acid|vanillylmandelic acid (VMA)]] and [[Homovanillic acid|homovanillic acid (HVA)]] levels. [[X-rays|X ray]] findings of neuroblastoma include; intrathoracic or intraabdominal [[soft tissue]] [[mass]], [[calcification]], remodeling of surrounding [[Rib|ribs]] & [[vertebral bodies]], thinning of surrounding [[pedicles]] and ill defined, [[metaphyseal]], lucent bone [[Lesion|lesions]] seen in [[Metastasis|metastases]]. [[Computed tomography|CT scan]] of the [[neck]], [[chest]] and [[abdomen]] is the [[Gold standard (test)|gold standard test]] in neuroblastoma as it can localize the [[tumor]] and determine degree of involvement as well. [[Computed tomography|CT scan]] in neuroblastoma can show the presence of; [[heterogeneous]] [[mass]], [[calcification]], [[necrosis]], compression of surrounding [[Blood vessel|vessels]], invasion of [[Psoas major muscle|psoas muscle]] & [[Kidney|kidneys]] and [[Edema|swollen]] [[Lymph node|lymph nodes]]. [[Magnetic resonance imaging|MRI]] is considered the most useful modality in staging of neuroblastoma. It is superior to [[Computed tomography|CT scan]] when determining [[Marrow infiltration by tumors, leukemias|marrow infiltration]] and intra spinal [[tumor]] extension. The definitive [[diagnosis]] of nueroblastoma is confirmed by a [[biopsy]]. Children oncology group (COG) risk stratification system determines the protocol of management used for neuroblastoma [[Patient|patients]]. COG risk stratification system divides the [[Patient|patients]] into 03 groups: low risk, intermediate risk and high risk patients. Low risk neuroblastoma [[Patient|patients]] are usually managed by either [[observation]] or [[surgical resection]] of the [[tumor]]. Intermediate risk [[Patient|patients]] are managed by [[neoadjuvant therapy]] in advance of a definitive [[surgical resection]]. High risk neuroblastoma [[Patient|patients]] are usually managed by a combination of [[surgery]], [[chemotherapy]], [[radiation therapy]], [[hematopoietic stem cell transplantation]], [[immunotherapy]] and [[isotretinoin]]. [[Surgery|Surgical intervention]] is [[Cure|curative]] as a single therapeutic modality for management of low risk neuroblastoma [[Patient|patients]]. In intermediate risk [[Patient|patients]], [[Surgery|surgical intervention]] must be followed by [[chemotherapy]]. However, the benefits of [[surgery]] to achieve complete [[tumor]] [[resection]] in high risk [[Patient|patients]] with [[metastatic disease]] is not clearly demonstrated.


==Historical Perspective==
==Historical Perspective==
Neuroblastoma was first described by Rudolf Virchow in 1864 as an abdominal tumor in a child as "glioma". Felix Marchand described characteristics of tumors from adrenal medulla and sympathetic nervous system in 1891. James Homer wright in 1910, described circular clumps of bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.
Neuroblastoma was first described by Rudolf Virchow in 1864 as an [[abdominal]] [[tumor]] in a child as "[[glioma]]". Felix Marchand described characteristics of [[Tumor|tumors]] from [[adrenal medulla]] and [[sympathetic nervous system]] in 1891. James Homer wright in 1910, described circular clumps of [[bone marrow]] ( now named "Homer-Wright pseudorosettes) and advanced the understanding that [[tumor]] originated from primitive [[Neuron|neural cells]] and could [[Metastasis|metastasize]] to [[bone]].


==Classification==
==Classification==
International neuroblastoma pathology classification system is used for the classification of neuroblastic tumors. It is subdivided in 02 main categories based on the morphologic features of neuroblastic tumors into; schwannian stroma-poor and schwannian stroma-rich/dominant.
International neuroblastoma [[pathology]] classification system is used for the classification of neuroblastic [[Tumor|tumors]]. It is subdivided in 02 main categories based on the [[Morphology|morphologic]] features of neuroblastic [[Tumor|tumors]] into; schwannian stroma-poor and schwannian stroma-rich/dominant.


==Pathophysiology==
==Pathophysiology==
Neuroblastoma arises from the neural crest cells, which are normally involved in development of sympathetic nervous system and adrenal glands. It is frequently located along the sympathetic nervous system structures including; adrenal glands, retroperitoneal organs, organ of zuckerkandl, paravertebral sympathetic chain and posterior mediastinum among others. Neuroblastoma tumor cells secrete catecholamine by products including vanillylmandelic acid (VMA) and homovanillic acid (HVA) and vasoactive intestinal polypeptide (VIP) hormone as well. It can metastasize to bone, liver, lungs and brain. The various genes involved in pathogenesis of neuroblastoma include; NBPF10, KIF1B, ALK, LMO1 and PHOX2A genes. The most common genetic mutation is gain of chromosome 17q and MYCN oncogene amplification predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of syndromes including; neurofibromatosis type 1, beckwith-weidman syndrome and hirschsprung disease. On gross pathology, the characteristic finding of neuroblastoma is a well defined, bulky and tan colored mass, that can be associated with fibrous pseudocapsule, necrosis or hemorrhage. On microscopic picture, the presence of round blue cells separated by thin fibrous septa are a characteristic finding.
Neuroblastoma arises from the [[neural crest cells]], which are normally involved in development of [[sympathetic nervous system]] and [[Adrenal gland|adrenal glands]]. It is frequently located along the [[sympathetic nervous system]] structures including; [[Adrenal gland|adrenal glands]], [[Retroperitoneal|retroperitoneal organs]], [[Organ of Zuckerkandl|organ of zuckerkandl]], [[Sympathetic chain|paravertebral sympathetic chain]] and [[posterior mediastinum]] among others. Neuroblastoma [[tumor]] [[Cell (biology)|cells]] secrete [[catecholamine]] by products including [[Vanillylmandelic acid|vanillylmandelic acid (VMA)]] and [[Homovanillic acid|homovanillic acid (HVA)]] and [[Vasoactive intestinal peptide|vasoactive intestinal polypeptide (VIP)]] [[hormone]] as well. It can [[Metastasis|metastasize]] to [[bone]], [[liver]], [[Lung|lungs]] and [[brain]]. The various [[Gene|genes]] involved in [[pathogenesis]] of neuroblastoma include; [[NBPF10]], [[KIF1B]], ALK, [[LMO1]] and [[PHOX2A]] [[Gene|genes]]. The most common [[genetic mutation]] is [[Gain-of-function mutation|gain]] of [[Chromosome 17|chromosome 17q]] and MYCN [[oncogene]] [[amplification]] predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of [[Syndrome|syndromes]] including; [[neurofibromatosis type 1]], [[Beckwith-Wiedemann syndrome|beckwith-wiedemann syndrome]] and [[Hirschsprung's disease|hirschsprung disease]]. On [[gross pathology]], the characteristic finding of neuroblastoma is a well defined, bulky and tan colored [[mass]], that can be associated with [[fibrous]] pseudocapsule, [[necrosis]] or [[hemorrhage]]. On [[Microscopy|microscopic picture]], the presence of round blue [[Cell (biology)|cells]] separated by thin [[fibrous]] [[septa]] are a characteristic finding.


==Causes==
==Causes==
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==Differentiating Multiple Myeloma from other Diseases==
==Differentiating Multiple Myeloma from other Diseases==
Intra-abdominal neuroblastoma must be differentiated from other diseases that cause abdominal distension and constipation such as Wilms tumor and ganglioneuroma. Intra-thoracic neuroblastoma must be differentiated from other diseases that cause shortness of breath and chronic cough such as intrathoracic lymphoma and extra lobar pulmonary sequestration.
Intra-abdominal neuroblastoma must be differentiated from other [[Disease|diseases]] that cause [[abdominal distension]] and [[constipation]] such as [[Wilms' tumor|Wilms tumor]] and [[ganglioneuroma]]. Intra-thoracic neuroblastoma must be differentiated from other [[Disease|diseases]] that cause [[shortness of breath]] and [[chronic cough]] such as intrathoracic [[lymphoma]] and extra lobar [[pulmonary]] sequestration.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
Neuroblastoma is the most common solid extracranial cancer in childhood and is the most common cancer in infancy. The overall incidence is 4.9 per 1,000,000 individuals in united states. Males are slightly more affected than females with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian race.
Neuroblastoma is the most common solid extracranial [[cancer]] in [[childhood]] and is the most common [[cancer]] in [[Infant|infancy]]. The overall [[incidence]] is 4.9 per 1,000,000 individuals in united states. [[Male|Males]] are slightly more affected than [[Female|females]] with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian [[race]].


==Risk Factors==
==Risk Factors==
The risk factors for neuroblastomas diagnosed during infancy include; maternal anemia during pregnancy, neonatal respiratory distress syndrome and low 1 minute Apgar score. However, the risk factors for neuroblastoma cases diagnosed at age 1 year or above is not known.
The risk factors for neuroblastomas diagnosed during infancy include; maternal anemia during pregnancy, neonatal respiratory distress syndrome and low 1 minute Apgar score. However, the [[Risk factor|risk factors]] for neuroblastoma cases diagnosed at [[age]] 1 year or above is not known.


==Screening==
==Screening==
There is insufficient evidence to recommend the routine screening for neuroblastoma as it has no mortality benefits.
There is insufficient [[evidence]] to recommend the routine [[Screening (medicine)|screening]] for neuroblastoma as it has no mortality benefits.


==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
Neuroblastoma may progress to develop fatigue, loss of appetite, joint pain and fever if left untreated. There is gradual development of site specific symptoms as the tumor size gradually increases. Complications of neuroblastoma include; persistent refractory diarrhea, horner's syndrome, hypertension, transverse myelopathy, anemia and suppressed immunity. The prognosis of neuroblastoma is generally regarded as poor, depending on the tumor extent at the time of diagnosis. The other prognostic factors for nuroblastoma include; patient's age, tumor stage and grade, genetic mutations and response to treatment.
Neuroblastoma may progress to develop [[fatigue]], [[loss of appetite]], [[joint pain]] and [[fever]] if left untreated. There is gradual development of site specific [[Symptom|symptoms]] as the [[tumor]] size gradually increases. [[Complication (medicine)|Complications]] of neuroblastoma include; [[Diarrhea|persistent refractory diarrhea]], [[horner's syndrome]], [[hypertension]], [[Transverse myelitis|transverse myelopathy]], [[anemia]] and [[Immunodeficiency|suppressed immunity]]. The [[prognosis]] of neuroblastoma is generally regarded as poor, depending on the [[tumor]] extent at the time of [[diagnosis]]. The other [[Prognosis|prognostic factors]] for nuroblastoma include; [[Patient|patient's]] [[age]], [[tumor]] stage and grade, [[genetic mutations]] and response to treatment.


==Diagnosis==
==Diagnosis==


===Staging===
===Staging===
According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the tumor size, lymph node involvement, and presence of metastesis. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma patients are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the tumor INSS stage, the patient's age, tumor grade, and the amplification of MYCN gene.
According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the [[tumor]] size, [[lymph node]] involvement, and presence of [[metastasis]]. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma patients are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the tumor INSS stage, the [[Patient|patient's]] [[age]], [[tumor]] grade, and the [[amplification]] of MYCN [[gene]].


===History and Symptoms===
===History and Symptoms===
A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include; abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).
A detailed [[History and Physical examination|history]] of presenting [[Symptom|symptoms]], [[family history]] and other associated [[Symptom|symptoms]] should be undertaken when evaluating a [[patient]] of neuroblastoma. General neuroblastoma [[Symptom|symptoms]] include; [[fever]], [[irritability]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Other [[Symptom|symptoms]] depending upon the [[anatomical]] location of neuroblastoma include; [[abdominal pain]], [[Abdominal distension|distension]] and [[constipation]] ([[abdomen]]), [[shortness of breath]], [[chronic cough]] & [[difficulty swallowing]] ([[posterior mediastinum]]), [[weakness]], [[numbness]], [[paralysis]] ([[retroperitoneum]]), visual defects, facial [[bruising]] ([[Head and neck anatomy|head & neck]]) and [[pallor]], [[bone pain]] ([[bone marrow]] [[Metastasis|metastases]]).


===Physical Examination===
===Physical Examination===
Physical examination findings of neuroblastoma include; fever, hypertension, tachycardia, pallor, ecchymoses, nystagmus, proptosis, ptosis, abdominal mass, brisk reflexes, sensory loss and ataxia.
[[Physical examination]] findings of neuroblastoma include; [[fever]], [[hypertension]], [[tachycardia]], [[pallor]], [[ecchymoses]], [[nystagmus]], [[proptosis]], [[ptosis]], [[abdominal mass]], [[Hyperreflexia|brisk reflexes]], [[sensory loss]] and [[ataxia]].


===Laboratory Findings===
===Laboratory Findings===
The laboratory findings in neuroblastoma include; ↓ [[hemoglobin]], ↑ [[ferritin]], ↑ [[catecholamine]], ↑ [[dopamine]], ↑ [[vanillylmandelic acid]] (VMA), ↑ [[homovanillic acid]] (HVA), ↑ [[lactate dehydrogenase]] and ↑ neuron-specific [[enolase]] levels. There are increased urinary [[catecholamine]], [[vanillylmandelic acid]] (VMA) and [[homovanillic acid]] (HVA) levels.
The laboratory findings in neuroblastoma include; ↓ [[hemoglobin]], ↑ [[ferritin]], ↑ [[catecholamine]], ↑ [[dopamine]], ↑ [[vanillylmandelic acid]] (VMA), ↑ [[homovanillic acid]] (HVA), ↑ [[lactate dehydrogenase]] and ↑ [[neuron-specific enolase]] levels. There are increased [[urinary]] [[catecholamine]], [[vanillylmandelic acid]] (VMA) and [[homovanillic acid]] (HVA) levels.


===X Ray===
===X Ray===
X ray findings of neuroblastoma include; intrathoracic or intraabdominal soft tissue mass, calcification, remodeling of surrounding ribs & vertebral bodies, thinning of surrounding pedicles and ill defined, metaphyseal, lucent bone lesions seen in metastases.
[[X ray]] findings of neuroblastoma include; intrathoracic or intraabdominal [[soft tissue]] [[mass]], [[calcification]], remodeling of surrounding [[Rib|ribs]] & [[vertebral bodies]], thinning of surrounding [[pedicles]] and ill defined, [[metaphyseal]], lucent [[bone]] [[Lesion|lesions]] seen in [[Metastasis|metastases]].


===CT===
===CT===
CT scan of the neck, chest and abdomen is the gold standard test in neuroblastoma as it can localize the tumor and determine degree of involvement as well. CT scan in neuroblastoma can show the presence of; heterogeneous mass, clacification, necrosis, compression of surrounding vessels, invasion of psoas muscle & kidneys and swollen lymph nodes.
[[Computed tomography|CT scan]] of the [[neck]], [[chest]] and [[abdomen]] is the [[Gold standard (test)|gold standard test]] in neuroblastoma as it can localize the [[tumor]] and determine degree of involvement as well. [[Computed tomography|CT scan]] in neuroblastoma can show the presence of; [[heterogeneous]] [[mass]], [[calcification]], [[necrosis]], compression of surrounding [[Blood vessel|vessels]], invasion of [[Psoas major muscle|psoas muscle]] & [[Kidney|kidneys]] and [[Edema|swollen]] [[Lymph node|lymph nodes]].


===MRI===
===MRI===
MRI is considered the most useful modality in staging of neuroblastoma. It is superior to CT scan when determining marrow infiltration and intra spinal tumor extension.MRI findings in neuroblastoma patients include; hypointense heterogeneous mass on T1 weighted image, heterogeneous/hyperintense enhancement due to necrosis and cyst formation seen on T2 weighted images.
[[Magnetic resonance imaging|MRI]] is considered the most useful modality in staging of neuroblastoma. It is superior to [[Computed tomography|CT scan]] when determining [[Bone marrow infiltration|marrow infiltration]] and intra spinal tumor extension.[[Magnetic resonance imaging|MRI]] findings in neuroblastoma [[Patient|patients]] include; hypointense [[heterogeneous]] [[mass]] on T1 weighted image, [[heterogeneous]]/hyperintense enhancement due to [[necrosis]] and [[cyst]] formation seen on T2 weighted images.


===Echocardiography or Ultrasound===
===Echocardiography or Ultrasound===
Ultrasound in the neuroblastoma shows heterogeneous solid masses due to vascular, necrotic and calcified content of the masses. When it is present in the adrenal, it displaces the kidneys inferiorly.
[[Ultrasound]] in the neuroblastoma shows [[heterogeneous]] solid masses due to [[vascular]], [[Necrosis|necrotic]] and [[Calcification|calcified]] content of the [[Mass|masses]]. When it is present in the [[Adrenal gland|adrenal]], it displaces the [[Kidney|kidneys]] [[inferiorly]].


===Other Imaging Findings===
===Other Imaging Findings===
Nuclear medicine studies used for diagnosis of neuroblastoma include fluorodeoxyglucose-18F positron emission tomography (18F- FDG PET) scan and metaiodobenzylguanidine (123I-MIBG) scintigraphy. 18F-FDG PET scan may distinguish stage 1 and 2 neuroblastoma from other differential diagnoses. 123I- MIBG scintigraphy distinguishes stage 3 and 4 neuroblastoma other differential diagnoses.
[[Nuclear medicine]] studies used for [[diagnosis]] of neuroblastoma include fluorodeoxyglucose-18F [[positron emission tomography]] (18F- FDG PET) scan and [[metaiodobenzylguanidine]] (123I-MIBG) [[scintigraphy]]. 18F-FDG [[Positron emission tomography|PET scan]] may distinguish stage 1 and 2 neuroblastoma from other [[Differential diagnosis|differential diagnoses]]. 123I- MIBG [[scintigraphy]] distinguishes stage 3 and 4 neuroblastoma other [[Differential diagnosis|differential diagnoses]].


===Other Diagnostic Studies===
===Other Diagnostic Studies===
The definitive diagnosis of nueroblastoma is confirmed by a [[biopsy]]. Charecterstic findings for neuroblastoma on microscopic histopathological analysis can be found [[Neuroblastoma pathophysiology|'''here''']].
The definitive [[diagnosis]] of nueroblastoma is confirmed by a [[biopsy]]. Charecterstic findings for neuroblastoma on [[microscopic]] [[histopathological]] analysis can be found [[Neuroblastoma pathophysiology|'''here''']].


==Treatment==
==Treatment==
===Medical Therapy===
===Medical Therapy===
Children oncology group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. COG risk stratification system divides the patients into 03 groups: low risk, intermediate risk and high risk patients. Low risk neuroblastoma patients are usually managed by either observation or surgical resection of the tumor. Intermediate risk patients are managed by neoadjuvant therapy in advance of a definitive surgical resection. High risk neuroblastoma patients are usually managed by a combination of surgery, chemotherapy, radiation therapy, hematopoietic stem cell transplantation, immunotherapy and isotetrinoin.
Children oncology group (COG) risk stratification system determines the protocol of management used for neuroblastoma [[Patient|patients]]. COG risk stratification system divides the [[Patient|patients]] into 03 groups: low risk, intermediate risk and high risk patients. Low risk neuroblastoma [[Patient|patients]] are usually managed by either [[observation]] or [[surgical resection]] of the [[tumor]]. Intermediate risk [[Patient|patients]] are managed by [[neoadjuvant therapy]] in advance of a definitive [[surgical resection]]. High risk neuroblastoma [[Patient|patients]] are usually managed by a combination of [[surgery]], [[chemotherapy]], [[radiation therapy]], [[hematopoietic stem cell transplantation]], [[immunotherapy]] and [[isotretinoin]].


===Surgery===
===Surgery===
Surgical intervention is curative as a single therapeutic modality for management of low risk neuroblastoma patients. In intermediate risk patients, surgical intervention must be followed by chemotherapy. However, the benefits of surgery to achieve complete tumor resection in high risk patients with metastatic disease is not clearly demonstrated.
[[Surgery|Surgical intervention]] is [[Cure|curative]] as a single therapeutic modality for management of low risk neuroblastoma patients. In intermediate risk [[Patient|patients]], [[Surgery|surgical intervention]] must be followed by [[chemotherapy]]. However, the benefits of [[surgery]] to achieve complete [[tumor]] [[resection]] in high risk [[Patient|patients]] with [[metastatic disease]] is not clearly demonstrated.


==References==
==References==

Latest revision as of 18:34, 5 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]

Overview

Neuroblastoma is the most common solid extracranial cancer in childhood and is the most common cancer in infancy. It is a malignant tumor that arises from neural crest cells, which are normally involved in the development of the sympathetic nervous system and adrenal glands. It is usually located along the sympathetic nervous system structures including; adrenal glands, retroperitoneal organs, paravertebral sympathetic chain, organ of zuckerkandl and posterior mediastinum. It was first described by Rudolf Virchow in 1864 as an abdominal tumor in a child as "glioma". James Homer Wright in 1910, described circular clumps of bone marrow (now named Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone. International neuroblastoma pathology classification system is used for the classification of neuroblastoma tumors, which divides it into 02 main categories based on morphologic features of neuroblastoma tumors into: schwannian stroma poor and schwannian stroma rich/dominant. Neuroblastoma tumor cells secrete catecholamine by products including vanillylmandelic acid (VMA) and homovanillic acid (HVA) and vasoactive intestinal polypeptide (VIP) hormone as well. The various genes involved in pathogenesis of neuroblastoma include; NBPF10, KIF1B, ALK, LMO1 and PHOX2A genes. The most common genetic mutation is gain of chromosome 17q and MYCN oncogene amplification predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of syndromes including; neurofibromatosis type 1, beckwith-weidemann syndrome and hirschsprung disease. On gross pathology, the characteristic finding of neuroblastoma is a well defined, bulky and tan colored mass, that can be associated with fibrous pseudocapsule, necrosis or hemorrhage. On microscopic picture, the presence of round blue cells separated by thin fibrous septa are a characteristic finding. There are no known established causes for neuroblastoma. The risk factors for neuroblastomas diagnosed during infancy include; maternal anemia during pregnancy, neonatal respiratory distress syndrome and low 1 minute Apgar score. However, the risk factors for neuroblastoma cases diagnosed at age 1 year or above is not known. The overall incidence is 4.9 per 1,000,000 individuals in united states. Males are slightly more affected than females with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian race. Intra-abdominal neuroblastoma must be differentiated from other diseases that cause abdominal distension and constipation such as Wilms tumor and ganglioneuroma. Intra-thoracic neuroblastoma must be differentiated from other diseases that cause shortness of breath and chronic cough such as intrathoracic lymphoma and extra lobar pulmonary sequestration. There are no routine screening tests for neuroblastoma due to lack of any mortality benefits. Neuroblastoma may progress to develop fatigue, loss of appetite, joint pain and fever if left untreated. There is gradual development of site specific symptoms as the tumor size gradually increases. Complications of neuroblastoma include; persistent refractory diarrhea, horner's syndrome, hypertension, transverse myelopathy, anemia and suppressed immunity. The prognosis of neuroblastoma is generally regarded as poor, depending on the tumor extent at the time of diagnosis. The other prognostic factors for nuroblastoma include; patient's age, tumor stage and grade, genetic mutations and response to treatment. According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the tumor size, lymph node involvement, and presence of metastasis. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma patients are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the tumor INSS stage, the patient's age, tumor grade, and the amplification of MYCN gene. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include; abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases). Physical examination findings of neuroblastoma include; fever, hypertension, tachycardia, pallor, ecchymoses, nystagmus, proptosis, ptosis, abdominal mass, brisk reflexes, sensory loss and ataxia. The laboratory findings in neuroblastoma include; ↓ hemoglobin, ↑ ferritin, ↑ catecholamine, ↑ dopamine, ↑ vanillylmandelic acid (VMA), ↑ homovanillic acid (HVA), ↑ lactate dehydrogenase and ↑ neuron-specific enolase levels. There are increased urinary catecholamine, vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels. X ray findings of neuroblastoma include; intrathoracic or intraabdominal soft tissue mass, calcification, remodeling of surrounding ribs & vertebral bodies, thinning of surrounding pedicles and ill defined, metaphyseal, lucent bone lesions seen in metastases. CT scan of the neck, chest and abdomen is the gold standard test in neuroblastoma as it can localize the tumor and determine degree of involvement as well. CT scan in neuroblastoma can show the presence of; heterogeneous mass, calcification, necrosis, compression of surrounding vessels, invasion of psoas muscle & kidneys and swollen lymph nodes. MRI is considered the most useful modality in staging of neuroblastoma. It is superior to CT scan when determining marrow infiltration and intra spinal tumor extension. The definitive diagnosis of nueroblastoma is confirmed by a biopsy. Children oncology group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. COG risk stratification system divides the patients into 03 groups: low risk, intermediate risk and high risk patients. Low risk neuroblastoma patients are usually managed by either observation or surgical resection of the tumor. Intermediate risk patients are managed by neoadjuvant therapy in advance of a definitive surgical resection. High risk neuroblastoma patients are usually managed by a combination of surgery, chemotherapy, radiation therapy, hematopoietic stem cell transplantation, immunotherapy and isotretinoin. Surgical intervention is curative as a single therapeutic modality for management of low risk neuroblastoma patients. In intermediate risk patients, surgical intervention must be followed by chemotherapy. However, the benefits of surgery to achieve complete tumor resection in high risk patients with metastatic disease is not clearly demonstrated.

Historical Perspective

Neuroblastoma was first described by Rudolf Virchow in 1864 as an abdominal tumor in a child as "glioma". Felix Marchand described characteristics of tumors from adrenal medulla and sympathetic nervous system in 1891. James Homer wright in 1910, described circular clumps of bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.

Classification

International neuroblastoma pathology classification system is used for the classification of neuroblastic tumors. It is subdivided in 02 main categories based on the morphologic features of neuroblastic tumors into; schwannian stroma-poor and schwannian stroma-rich/dominant.

Pathophysiology

Neuroblastoma arises from the neural crest cells, which are normally involved in development of sympathetic nervous system and adrenal glands. It is frequently located along the sympathetic nervous system structures including; adrenal glands, retroperitoneal organs, organ of zuckerkandl, paravertebral sympathetic chain and posterior mediastinum among others. Neuroblastoma tumor cells secrete catecholamine by products including vanillylmandelic acid (VMA) and homovanillic acid (HVA) and vasoactive intestinal polypeptide (VIP) hormone as well. It can metastasize to bone, liver, lungs and brain. The various genes involved in pathogenesis of neuroblastoma include; NBPF10, KIF1B, ALK, LMO1 and PHOX2A genes. The most common genetic mutation is gain of chromosome 17q and MYCN oncogene amplification predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of syndromes including; neurofibromatosis type 1, beckwith-wiedemann syndrome and hirschsprung disease. On gross pathology, the characteristic finding of neuroblastoma is a well defined, bulky and tan colored mass, that can be associated with fibrous pseudocapsule, necrosis or hemorrhage. On microscopic picture, the presence of round blue cells separated by thin fibrous septa are a characteristic finding.

Causes

There are no known established causes for neuroblastoma.

Differentiating Multiple Myeloma from other Diseases

Intra-abdominal neuroblastoma must be differentiated from other diseases that cause abdominal distension and constipation such as Wilms tumor and ganglioneuroma. Intra-thoracic neuroblastoma must be differentiated from other diseases that cause shortness of breath and chronic cough such as intrathoracic lymphoma and extra lobar pulmonary sequestration.

Epidemiology and Demographics

Neuroblastoma is the most common solid extracranial cancer in childhood and is the most common cancer in infancy. The overall incidence is 4.9 per 1,000,000 individuals in united states. Males are slightly more affected than females with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian race.

Risk Factors

The risk factors for neuroblastomas diagnosed during infancy include; maternal anemia during pregnancy, neonatal respiratory distress syndrome and low 1 minute Apgar score. However, the risk factors for neuroblastoma cases diagnosed at age 1 year or above is not known.

Screening

There is insufficient evidence to recommend the routine screening for neuroblastoma as it has no mortality benefits.

Natural History, Complications and Prognosis

Neuroblastoma may progress to develop fatigue, loss of appetite, joint pain and fever if left untreated. There is gradual development of site specific symptoms as the tumor size gradually increases. Complications of neuroblastoma include; persistent refractory diarrhea, horner's syndrome, hypertension, transverse myelopathy, anemia and suppressed immunity. The prognosis of neuroblastoma is generally regarded as poor, depending on the tumor extent at the time of diagnosis. The other prognostic factors for nuroblastoma include; patient's age, tumor stage and grade, genetic mutations and response to treatment.

Diagnosis

Staging

According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the tumor size, lymph node involvement, and presence of metastasis. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma patients are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the tumor INSS stage, the patient's age, tumor grade, and the amplification of MYCN gene.

History and Symptoms

A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include; abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).

Physical Examination

Physical examination findings of neuroblastoma include; fever, hypertension, tachycardia, pallor, ecchymoses, nystagmus, proptosis, ptosis, abdominal mass, brisk reflexes, sensory loss and ataxia.

Laboratory Findings

The laboratory findings in neuroblastoma include; ↓ hemoglobin, ↑ ferritin, ↑ catecholamine, ↑ dopamine, ↑ vanillylmandelic acid (VMA), ↑ homovanillic acid (HVA), ↑ lactate dehydrogenase and ↑ neuron-specific enolase levels. There are increased urinary catecholamine, vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels.

X Ray

X ray findings of neuroblastoma include; intrathoracic or intraabdominal soft tissue mass, calcification, remodeling of surrounding ribs & vertebral bodies, thinning of surrounding pedicles and ill defined, metaphyseal, lucent bone lesions seen in metastases.

CT

CT scan of the neck, chest and abdomen is the gold standard test in neuroblastoma as it can localize the tumor and determine degree of involvement as well. CT scan in neuroblastoma can show the presence of; heterogeneous mass, calcification, necrosis, compression of surrounding vessels, invasion of psoas muscle & kidneys and swollen lymph nodes.

MRI

MRI is considered the most useful modality in staging of neuroblastoma. It is superior to CT scan when determining marrow infiltration and intra spinal tumor extension.MRI findings in neuroblastoma patients include; hypointense heterogeneous mass on T1 weighted image, heterogeneous/hyperintense enhancement due to necrosis and cyst formation seen on T2 weighted images.

Echocardiography or Ultrasound

Ultrasound in the neuroblastoma shows heterogeneous solid masses due to vascular, necrotic and calcified content of the masses. When it is present in the adrenal, it displaces the kidneys inferiorly.

Other Imaging Findings

Nuclear medicine studies used for diagnosis of neuroblastoma include fluorodeoxyglucose-18F positron emission tomography (18F- FDG PET) scan and metaiodobenzylguanidine (123I-MIBG) scintigraphy. 18F-FDG PET scan may distinguish stage 1 and 2 neuroblastoma from other differential diagnoses. 123I- MIBG scintigraphy distinguishes stage 3 and 4 neuroblastoma other differential diagnoses.

Other Diagnostic Studies

The definitive diagnosis of nueroblastoma is confirmed by a biopsy. Charecterstic findings for neuroblastoma on microscopic histopathological analysis can be found here.

Treatment

Medical Therapy

Children oncology group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. COG risk stratification system divides the patients into 03 groups: low risk, intermediate risk and high risk patients. Low risk neuroblastoma patients are usually managed by either observation or surgical resection of the tumor. Intermediate risk patients are managed by neoadjuvant therapy in advance of a definitive surgical resection. High risk neuroblastoma patients are usually managed by a combination of surgery, chemotherapy, radiation therapy, hematopoietic stem cell transplantation, immunotherapy and isotretinoin.

Surgery

Surgical intervention is curative as a single therapeutic modality for management of low risk neuroblastoma patients. In intermediate risk patients, surgical intervention must be followed by chemotherapy. However, the benefits of surgery to achieve complete tumor resection in high risk patients with metastatic disease is not clearly demonstrated.

References


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