Multiple endocrine neoplasia type 1 historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Multiple endocrine neoplasia type 1 was first described by Dr. Erdheim, a German physician, in 1903 by reporting a case of an acromegalic patient with pituitary adenoma and three enlarged parathyroid glands.
Historical Perspective
| Years | Scientist | Contribution |
|---|---|---|
| 1903 | Erdheim | Reported case of an acromegalic patient with pituitary adenoma and three enlarged parathyroid glands |
| 1953 | Underdahl | Reported case series of patients with syndrome of pituitary, parathyroid, and pancreatic islet adenomas. |
| 1954 | Wermer | Identified that multiple endocrine neoplasia was transmitted as a dominant trait |
| 1962 | Williams and Celestin | First described bronchial carcinoid as a feature of multiple endocrine neoplasia type 1. |
| 1963 | Jacobs and Underwood | Reported case of hypoglycemia and islet cell adenomas in 3 members of the family, with father having hyperparathyroidism and broncial carcinoma and son and daughter with idiopathic epilepsy |
| 1966 | Guida | Identified pituitary adenoma and duodenal carcinoid in patients with multiple endocrine neoplasia type 1 syndrome |
| 1967 | Johnson | Presented a multiple endocrine neoplasia type 1 case devoid of peptic ulcer |
| 1968 | Steiner | Introduced the term "multiple endocrine neoplasia" (MEN) to describe disorders featuring combinations of endocrine tumors and proposed the terms 'Wermer syndrome' for MEN 1 and 'Sipple syndrome' for MEN 2 |
| 1972 | Vance | Suggested the importance of primary genetic lesion in endocrine adenomatosis in developing neoplasia and hyperfunctioning of islet of langerhans.[1] |
| 1982 | McCarthy | Identified 2 different causes of Zollinger-Ellison syndrome, malignant type and the one linked with multiple endocrine neoplasia type 1 |
| 1983 | Hershon | Identified family members from Pacific Northwest with prolactinomas but with no pancreatic tumors. |
| 1985 | Bear | Referred the disorders reported from Burin as multiple endocrine neoplasia type 1 Burin. |
| 1986 | Brandi | Suggested the humoral cause of primary hyperparathyroidism in familial multiple endocrine neoplasia type 1 |
| 1986 | Schimke | Suggested a 2 step model of pathogenesis which include germline mutation followed by somatic mutation later |
| 1986 | Bahn | Identified 25 year old monozygotic twins with one having primary hyperparathyroidism, Zollinger-Ellison syndrome, cushing's disease, and hyperprolactinemia and the other have primary hyperparathyroidism and hyperprolactinemia |
| 1986 | Maton | Identified that cushing's syndrome is more common with Zollinger-Ellison syndrome |
| 1988 | The multiple endocrine neoplasia type 1 locus was assigned to chromosome 11 (11q13) | |
| 1993 | Gaitan | Described mother and daughter with cushing's disease due to ACTH secreting tumor |
| 1994 | Petty | Identified that gene involved in Pacific Northwest studies and Burin studies linked to 11q chromosome. |
| 1997 | Darling | Suggested that one of the diagnostic findings of multiple endocrine neoplasia type 1 is cutaneous manifestations |
| 1998 | The multiple endocrine neoplasia type 1 gene was cloned.[2] | |
| 1999 | Yu | Identified that gastrinoma growth is the single most important factor in deciding the long term survival of patients with Zollinger-Ellison syndrome |
| 2001 | Bordi | Identified patients with MEN syndrome to have carcinoid tumors |