Multiple endocrine neoplasia type 1 natural history, complications and prognosis
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The natural history largely depends on the manifestation and virulence of the manifestations. The manifestations of multiple endocrine neoplasia type-1 (MEN-1) usually develop in the first, second, or third decade of life. If left untreated, manifestations of MEN-1 may gradually worsen, and patients may die of complications of the disease. Life-threatening complications of MEN-1 include gastrointestinal bleeding, convulsions, hypokalemia, hypoglycemia, and venous thrombosis. Although many tumors associated with MEN-1 are benign, approximately half of people with MEN-1 eventually develop a cancerous tumor. The prognosis of MEN-1 is generally good with treatment. Development of pancreatic cancer is associated with poor prognosis.
- The natural history of MEN-1 is difficult to delineate given the rarity of the disease. 
- The manifestations of MEN-1 usually develop in the first, second, or third decade of life.
- The age at which MEN-1 develops may vary significantly, even among members of the same family.
- If left untreated, manifestations of MEN-1 may gradually worsen, and patients may die of complications of the disease.
- The prognosis of MEN-1 is generally good with treatment.
- Early death can occur due to the effect of hormones produced by these tumors. 
- Although many tumors associated with MEN-1 are benign, approximately half of people with MEN-1 will eventually develop a cancerous tumor. 
- The presence of pancreatic tumors is associated with a particularly poor prognosis among patients with MEN-1.
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