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{{Infobox_gene}}
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'''28S ribosomal protein S30, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPS30'' [[gene]].<ref name="pmid10640817">{{cite journal |vauthors=Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M | title = Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52 | journal = Cytogenet Cell Genet | volume = 87 | issue = 1–2 | pages = 85–8 |date=May 2000 | pmid = 10640817 | pmc =  | doi =10.1159/000015397 }}</ref><ref name="pmid11279123">{{cite journal |vauthors=Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL | title = The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present | journal = J Biol Chem | volume = 276 | issue = 22 | pages = 19363–74 |date=May 2001 | pmid = 11279123 | pmc =  | doi = 10.1074/jbc.M100727200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRPS30 mitochondrial ribosomal protein S30| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10884| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitochondrial ribosomal protein S30
| HGNCid = 8769
| Symbol = MRPS30
| AltSymbols =; PAP; DKFZp566B2024; MRP-S30; PDCD9
| OMIM =
| ECnumber =
| Homologene = 9607
| MGIid = 1926237
| GeneAtlas_image1 = PBB_GE_MRPS30_218398_at_tn.png
  | GeneAtlas_image2 = PBB_GE_MRPS30_222275_at_tn.png
  | Function = {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}}  
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005840 |text = ribosome}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10884
    | Hs_Ensembl = ENSG00000112996
    | Hs_RefseqProtein = NP_057724
    | Hs_RefseqmRNA = NM_016640
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 44844784
    | Hs_GenLoc_end = 44856287
    | Hs_Uniprot = Q9NP92
    | Mm_EntrezGene = 59054
    | Mm_Ensembl = ENSMUSG00000021731
    | Mm_RefseqmRNA = NM_021556
    | Mm_RefseqProtein = NP_067531
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 119499391
    | Mm_GenLoc_end = 119506533
    | Mm_Uniprot = Q9D0G0
  }}
}}
'''Mitochondrial ribosomal protein S30''', also known as '''MRPS30''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRPS30 mitochondrial ribosomal protein S30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10884| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.<ref name="entrez">{{cite web | title = Entrez Gene: MRPS30 mitochondrial ribosomal protein S30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10884| accessdate = }}</ref>
| summary_text = Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small [[28S]] subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 28S subunit protein that is similar to the chicken pro-[[apoptosis|apoptotic]] protein [[NFKB2|p52]]. [[Transcript variant]]s using alternative promoters or [[polyA]] sites have been mentioned in the literature but the complete description of these sequences is not available.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468-80 |year= 2003 |pmid= 12706105 |doi=  }}
*{{cite journal  |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kenmochi N, Suzuki T, Uechi T, ''et al.'' |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65-70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders |journal=Genomics |volume=77 |issue= 1–2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal | author=Cavdar Koc E, Burkhart W, Blackburn K, ''et al.'' |title=The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19363-74 |year= 2001 |pmid= 11279123 |doi= 10.1074/jbc.M100727200 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Carim L, Sumoy L, Nadal M, ''et al.'' |title=Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 85-8 |year= 2000 |pmid= 10640817 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{GeneticTranslation}}
{{Ribosome subunits}}
{{gene-5-stub}}
{{protein-stub}}
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[[Category:Ribosomal proteins]]

Latest revision as of 06:52, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[3]

References

  1. ↑ Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet. 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817.
  2. ↑ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  3. ↑ 3.0 3.1 "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30".

Further reading


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