Lymphoplasmacytic lymphoma classification: Difference between revisions

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{{CMG}}; {{AE}}{{S.M.}}
{{CMG}}; {{AE}}{{S.M.}}
==Overview==
==Overview==
There is no established system for the classification of lymphoplasmacytic lymphoma. However, according to a devised criteria based upon patient's symptoms, Waldenström's macroglobulinemia can be further classified into smoldering/asymptomatic and symptomatic WM .
There is no established [[system]] for the [[classification]] of [[lymphoplasmacytic lymphoma]]. However, according to a devised [[criteria]] [[Based on Symptoms|based upon patient's symptoms]], [[Waldenström's macroglobulinemia]] can be further [[Classification|classified]] into smoldering/[[asymptomatic]] and [[symptomatic]] [[Waldenstrom macroglobulinemia]]([[Waldenström's macroglobulinemia|WM)]].  


==Classification==
==Classification==
There is no established system for the classification of Waldenström's macroglobulinemia. However, according to a devised criteria based upon patient's symptoms, it can be classified into:<ref name="pmid15735132">{{cite journal| author=Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP| title=Diagnosis and management of Waldenstrom's macroglobulinemia. | journal=J Clin Oncol | year= 2005 | volume= 23 | issue= 7 | pages= 1564-77 | pmid=15735132 | doi=10.1200/JCO.2005.03.144 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15735132  }} </ref>
There is no established [[system]] for the [[classification]] of [[lymphoplasmacytic lymphoma]]. However, according to a devised [[criteria]] [[Based on Symptoms|based upon patient's symptoms]], [[Waldenström's macroglobulinemia]] can be further [[Classification|classified]] into:<ref name="pmid15735132">{{cite journal| author=Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP| title=Diagnosis and management of Waldenstrom's macroglobulinemia. | journal=J Clin Oncol | year= 2005 | volume= 23 | issue= 7 | pages= 1564-77 | pmid=15735132 | doi=10.1200/JCO.2005.03.144 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15735132  }} </ref>
*Symptomatic Waldenstrom macroglobulinemia.
 
*Asymptomatic/Smoldering Waldenstrom macroglobulinemia (SWM).<ref name="pmid12720119">{{cite journal| author=Kyle RA, Treon SP, Alexanian R, Barlogie B, Björkholm M, Dhodapkar M et al.| title=Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 116-20 | pmid=12720119 | doi=10.1053/sonc.2003.50038 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720119  }} </ref>
*[[Symptomatic]] [[Waldenstrom macroglobulinemia]]
{| class="wikitable"
*[[Asymptomatic]]/Smoldering [[Waldenstrom macroglobulinemia]] (SWM)<ref name="pmid12720119">{{cite journal| author=Kyle RA, Treon SP, Alexanian R, Barlogie B, Björkholm M, Dhodapkar M et al.| title=Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 116-20 | pmid=12720119 | doi=10.1053/sonc.2003.50038 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720119  }} </ref>
|+ '''Classification of WM and Related Disorders'''
 
{|  
|+'''Classification of [[Waldenstrom macroglobulinemia]] (WM) and Related Disorders'''
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptomatic WM
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! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
! style="background:#4479BA; color: #FFFFFF;" align="center" + |MGUS
|-
|-
| style="background:#DCDCDC;" align="center" + |IgM monoclonal protein
! align="center" style="background:#DCDCDC;" + |[[IgM monoclonal protein]]
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
|-
|-
| style="background:#DCDCDC;" align="center" + |Bone marrow infiltration
! align="center" style="background:#DCDCDC;" + |Bone marrow infiltration
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
|-
|-
| style="background:#DCDCDC;" align="center" + |Symptoms attributable to IgM
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to IgM
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
|-
|-
| style="background:#DCDCDC;" align="center" + |Symptoms attributable to tumor infiltration
! align="center" style="background:#DCDCDC;" + |Symptoms attributable to tumor infiltration
| style="background:#F5F5F5;" align="center" + |+
| style="background:#F5F5F5;" align="center" + | +
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
| style="background:#F5F5F5;" align="center" + |-
| style="background:#F5F5F5;" align="center" + | -
|}
|}<br />


==References==
==References==
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{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category: (name of the system)]]
[[Category:Disease]]
[[Category:Blood]]
[[Category:Hematology]]

Latest revision as of 17:26, 8 April 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

There is no established system for the classification of lymphoplasmacytic lymphoma. However, according to a devised criteria based upon patient's symptoms, Waldenström's macroglobulinemia can be further classified into smoldering/asymptomatic and symptomatic Waldenstrom macroglobulinemia(WM).

Classification

There is no established system for the classification of lymphoplasmacytic lymphoma. However, according to a devised criteria based upon patient's symptoms, Waldenström's macroglobulinemia can be further classified into:[1]

Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -


References

  1. Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP (2005). "Diagnosis and management of Waldenstrom's macroglobulinemia". J Clin Oncol. 23 (7): 1564–77. doi:10.1200/JCO.2005.03.144. PMID 15735132.
  2. Kyle RA, Treon SP, Alexanian R, Barlogie B, Björkholm M, Dhodapkar M; et al. (2003). "Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia". Semin Oncol. 30 (2): 116–20. doi:10.1053/sonc.2003.50038. PMID 12720119.

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