Loxapine (oral): Difference between revisions
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'''Loxapine''' (sold as '''Loxapac'''®, '''Loxitane'''®) is a [[typical antipsychotic]] [[medication]], used primarily in the treatment of [[schizophrenia]]. It is a member of the [[dibenzoxazepine]] class and as a [[dibenzazepine]] [[Derivative (chemistry)|derivative]], it is structurally related to [[clozapine]] (which belongs to the chemically closely akin class of [[dibenzodiazepines]]). Several researchers have argued that Loxapine may behave as an [[atypical antipsychotic]] (PMID 10340686). | '''Loxapine''' (sold as '''Loxapac'''®, '''Loxitane'''®) is a [[typical antipsychotic]] [[medication]], used primarily in the treatment of [[schizophrenia]]. It is a member of the [[dibenzoxazepine]] class and as a [[dibenzazepine]] [[Derivative (chemistry)|derivative]], it is structurally related to [[clozapine]] (which belongs to the chemically closely akin class of [[dibenzodiazepines]]). Several researchers have argued that Loxapine may behave as an [[atypical antipsychotic]] (PMID 10340686). | ||
Revision as of 17:02, 9 August 2012
| Clinical data | |
|---|---|
| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | Oral-4 hours |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C18H18ClN3O |
| Molar mass | 327.808 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and as a dibenzazepine derivative, it is structurally related to clozapine (which belongs to the chemically closely akin class of dibenzodiazepines). Several researchers have argued that Loxapine may behave as an atypical antipsychotic (PMID 10340686).
Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant (PMID 1860915).
Side effects
The most significant side-effects of loxapine are excessive salivation and indifference to surroundings. Loxapine, if administered to normal persons causes emotional quietening and insensitivity. In persons with psychosis, it may control aggressive behaviour and restlessness, and reduce the severity of hallucinations and delusions. Other Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor, gynecomastia and sedation.
Dosage
The typical starting dosage is 10mg twice daily; usual dose range 30-50mg twice daily; maximum recommended dosage is 250mg per day.
External links
- Product monograph from Medscape (free registration required).
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Typical antipsychotics
- Drugs