Laminin, alpha 1: Difference between revisions

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{{Infobox_gene}}
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'''Laminin subunit alpha-1''' is a [[protein]] that in humans is encoded by the ''LAMA1'' [[gene]].<ref name="pmid2591971">{{cite journal |vauthors=Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J | title = Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3 | journal = Genomics | volume = 5 | issue = 4 | pages = 932–5 |date=January 1990 | pmid = 2591971 | pmc =  | doi =10.1016/0888-7543(89)90136-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LAMA1 laminin, alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284217| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Laminin, alpha 1
| HGNCid = 6481
| Symbol = LAMA1
| AltSymbols =; LAMA
| OMIM = 150320
| ECnumber =
| Homologene = 21146
| MGIid = 99892
| GeneAtlas_image1 = PBB_GE_LAMA1_gnf1h03218_at_tn.png
  | GeneAtlas_image2 = PBB_GE_LAMA1_gnf1h07866_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0005608 |text = laminin-3 complex}}
  | Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 284217
    | Hs_Ensembl = ENSG00000101680
    | Hs_RefseqProtein = XP_001130075
    | Hs_RefseqmRNA = XM_001130075
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 6932078
    | Hs_GenLoc_end = 7107813
    | Hs_Uniprot = P25391
    | Mm_EntrezGene = 16772
    | Mm_Ensembl = ENSMUSG00000032796
    | Mm_RefseqmRNA = NM_008480
    | Mm_RefseqProtein = NP_032506
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 67602232
    | Mm_GenLoc_end = 67727594
    | Mm_Uniprot = P19137
  }}
}}
'''Laminin, alpha 1''', also known as '''LAMA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LAMA1 laminin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284217| accessdate = }}</ref>


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==Interactions==
Laminin, alpha 1 has been shown to [[Protein-protein interaction|interact]] with [[FBLN2]].<ref name=pmid9006922>{{cite journal |last=Utani |first=A |authorlink= |author2=Nomizu M |author3=Yamada Y  |date=January 1997  |title=Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences |journal=J. Biol. Chem. |volume=272 |issue=5 |pages=2814–20 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9006922 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.5.2814 }}</ref><ref name=pmid10934193>{{cite journal |last=Talts |first=J F |authorlink= |author2=Sasaki T |author3=Miosge N |author4=Göhring W |author5=Mann K |author6=Mayne R |author7=Timpl R  |date=November 2000  |title=Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues |journal=J. Biol. Chem. |volume=275 |issue=45 |pages=35192–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10934193 |doi = 10.1074/jbc.M003261200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Haaparanta T, Uitto J, Ruoslahti E, Engvall E |title=Molecular cloning of the cDNA encoding human laminin A chain. |journal=Matrix |volume=11 |issue= 3 |pages= 151-60 |year= 1991 |pmid= 1714537 |doi=  }}
*{{cite journal  |vauthors=Haaparanta T, Uitto J, Ruoslahti E, Engvall E |title=Molecular cloning of the cDNA encoding human laminin A chain. |journal=Matrix |volume=11 |issue= 3 |pages= 151–60 |year= 1991 |pmid= 1714537 |doi=  10.1016/s0934-8832(11)80153-8}}
*{{cite journal | author=Nissinen M, Vuolteenaho R, Boot-Handford R, ''et al.'' |title=Primary structure of the human laminin A chain. Limited expression in human tissues. |journal=Biochem. J. |volume=276 ( Pt 2) |issue=  |pages= 369-79 |year= 1991 |pmid= 2049067 |doi=  }}
*{{cite journal   |vauthors=Nissinen M, Vuolteenaho R, Boot-Handford R, etal |title=Primary structure of the human laminin A chain. Limited expression in human tissues |journal=Biochem. J. |volume=276 ( Pt 2) |issue=  Pt 2|pages= 369–79 |year= 1991 |pmid= 2049067 |doi= | pmc=1151101 }}
*{{cite journal | author=Taraboletti G, Rao CN, Krutzsch HC, ''et al.'' |title=Sulfatide-binding domain of the laminin A chain. |journal=J. Biol. Chem. |volume=265 |issue= 21 |pages= 12253-8 |year= 1990 |pmid= 2373692 |doi=  }}
*{{cite journal   |vauthors=Taraboletti G, Rao CN, Krutzsch HC, etal |title=Sulfatide-binding domain of the laminin A chain |journal=J. Biol. Chem. |volume=265 |issue= 21 |pages= 12253–8 |year= 1990 |pmid= 2373692 |doi=  }}
*{{cite journal | author=Nagayoshi T, Mattei MG, Passage E, ''et al.'' |title=Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. |journal=Genomics |volume=5 |issue= 4 |pages= 932-5 |year= 1990 |pmid= 2591971 |doi=  }}
*{{cite journal   |vauthors=Olsen D, Nagayoshi T, Fazio M, etal |title=Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells |journal=Lab. Invest. |volume=60 |issue= 6 |pages= 772–82 |year= 1989 |pmid= 2733383 |doi=  }}
*{{cite journal  | author=Olsen D, Nagayoshi T, Fazio M, ''et al.'' |title=Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. |journal=Lab. Invest. |volume=60 |issue= 6 |pages= 772-82 |year= 1989 |pmid= 2733383 |doi=  }}
*{{cite journal  |vauthors=Leivo I, Engvall E |title=C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast |journal=J. Cell Biol. |volume=103 |issue= 3 |pages= 1091–100 |year= 1986 |pmid= 3488995 |doi=10.1083/jcb.103.3.1091  | pmc=2114300 }}
*{{cite journal | author=Leivo I, Engvall E |title=C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast. |journal=J. Cell Biol. |volume=103 |issue= 3 |pages= 1091-100 |year= 1986 |pmid= 3488995 |doi= }}
*{{cite journal   |vauthors=Wewer UM, Gerecke DR, Durkin ME, etal |title=Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas |journal=Genomics |volume=24 |issue= 2 |pages= 243–52 |year= 1995 |pmid= 7698745 |doi= 10.1006/geno.1994.1612 }}
*{{cite journal | author=Wewer UM, Gerecke DR, Durkin ME, ''et al.'' |title=Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. |journal=Genomics |volume=24 |issue= 2 |pages= 243-52 |year= 1995 |pmid= 7698745 |doi= 10.1006/geno.1994.1612 }}
*{{cite journal   |vauthors=Yamada H, Shimizu T, Tanaka T, etal |title=Dystroglycan is a binding protein of laminin and merosin in peripheral nerve |journal=FEBS Lett. |volume=352 |issue= 1 |pages= 49–53 |year= 1994 |pmid= 7925941 |doi=10.1016/0014-5793(94)00917-1  }}
*{{cite journal  | author=Yamada H, Shimizu T, Tanaka T, ''et al.'' |title=Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. |journal=FEBS Lett. |volume=352 |issue= 1 |pages= 49-53 |year= 1994 |pmid= 7925941 |doi=  }}
*{{cite journal  |vauthors=Moser TL, Enghild JJ, Pizzo SV, Stack MS |title=The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18917–23 |year= 1993 |pmid= 8360181 |doi=  }}
*{{cite journal | author=Moser TL, Enghild JJ, Pizzo SV, Stack MS |title=The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18917-23 |year= 1993 |pmid= 8360181 |doi=  }}
*{{cite journal   |vauthors=Yurchenco PD, Sung U, Ward MD, etal |title=Recombinant laminin G domain mediates myoblast adhesion and heparin binding |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8356–65 |year= 1993 |pmid= 8463343 |doi=  }}
*{{cite journal  | author=Yurchenco PD, Sung U, Ward MD, ''et al.'' |title=Recombinant laminin G domain mediates myoblast adhesion and heparin binding. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8356-65 |year= 1993 |pmid= 8463343 |doi=  }}
*{{cite journal  |vauthors=Ancsin JB, Kisilevsky R |title=Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 406–13 |year= 1997 |pmid= 8995276 |doi=10.1074/jbc.272.1.406 }}
*{{cite journal  | author=Ancsin JB, Kisilevsky R |title=Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 406-13 |year= 1997 |pmid= 8995276 |doi=  }}
*{{cite journal  | author=Zahedi K |title=Characterization of the binding of serum amyloid P to laminin |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2143–8 |year= 1997 |pmid= 8999915 |doi= 10.1074/jbc.272.4.2143 }}
*{{cite journal  | author=Zahedi K |title=Characterization of the binding of serum amyloid P to laminin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2143-8 |year= 1997 |pmid= 8999915 |doi=  }}
*{{cite journal  |vauthors=Utani A, Nomizu M, Yamada Y |title=Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2814–20 |year= 1997 |pmid= 9006922 |doi=10.1074/jbc.272.5.2814 }}
*{{cite journal  | author=Utani A, Nomizu M, Yamada Y |title=Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2814-20 |year= 1997 |pmid= 9006922 |doi=  }}
*{{cite journal  |vauthors=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145–58 |year= 1997 |pmid= 9136074 |doi=10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U }}
*{{cite journal  | author=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145-58 |year= 1997 |pmid= 9136074 |doi= }}
*{{cite journal  |vauthors=Chen M, Marinkovich MP, Veis A, etal |title=Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14516–22 |year= 1997 |pmid= 9169408 |doi=10.1074/jbc.272.23.14516  }}
*{{cite journal | author=Chen M, Marinkovich MP, Veis A, ''et al.'' |title=Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14516-22 |year= 1997 |pmid= 9169408 |doi=  }}
*{{cite journal   |vauthors=Schuger L, Skubitz AP, Zhang J, etal |title=Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development |journal=J. Cell Biol. |volume=139 |issue= 2 |pages= 553–62 |year= 1997 |pmid= 9334356 |doi=10.1083/jcb.139.2.553  | pmc=2139794 }}
*{{cite journal  | author=Schuger L, Skubitz AP, Zhang J, ''et al.'' |title=Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. |journal=J. Cell Biol. |volume=139 |issue= 2 |pages= 553-62 |year= 1997 |pmid= 9334356 |doi=  }}
*{{cite journal  |vauthors=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2–3 |pages= 255–9 |year= 1998 |pmid= 9597096 |doi=  }}
*{{cite journal  | author=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2-3 |pages= 255-9 |year= 1998 |pmid= 9597096 |doi=  }}
*{{cite journal  |vauthors=O'Grady P, Thai TC, Saito H |title=The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1675–84 |year= 1998 |pmid= 9647658 |doi=10.1083/jcb.141.7.1675  | pmc=2133008 }}
*{{cite journal | author=O'Grady P, Thai TC, Saito H |title=The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1675-84 |year= 1998 |pmid= 9647658 |doi= }}
*{{cite journal   |vauthors=Ettner N, Göhring W, Sasaki T, etal |title=The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan |journal=FEBS Lett. |volume=430 |issue= 3 |pages= 217–21 |year= 1998 |pmid= 9688542 |doi=10.1016/S0014-5793(98)00601-2 }}
*{{cite journal  | author=Ettner N, Göhring W, Sasaki T, ''et al.'' |title=The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. |journal=FEBS Lett. |volume=430 |issue= 3 |pages= 217-21 |year= 1998 |pmid= 9688542 |doi= }}
*{{cite journal  |vauthors=Ludwig HC, Rausch S, Schallock K, Markakis E |title=Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry |journal=Anticancer Res. |volume=19 |issue= 3A |pages= 1747–52 |year= 1999 |pmid= 10470109 |doi=  }}
*{{cite journal  | author=Ludwig HC, Rausch S, Schallock K, Markakis E |title=Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. |journal=Anticancer Res. |volume=19 |issue= 3A |pages= 1747-52 |year= 1999 |pmid= 10470109 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{Fibrous proteins}}
 
 
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[[Category:Laminins]]

Latest revision as of 19:27, 2 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.[1][2]


Interactions

Laminin, alpha 1 has been shown to interact with FBLN2.[3][4]

References

  1. ↑ Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J (January 1990). "Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3". Genomics. 5 (4): 932–5. doi:10.1016/0888-7543(89)90136-5. PMID 2591971.
  2. ↑ "Entrez Gene: LAMA1 laminin, alpha 1".
  3. ↑ Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. UNITED STATES. 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. ISSN 0021-9258. PMID 9006922.
  4. ↑ Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. UNITED STATES. 275 (45): 35192–9. doi:10.1074/jbc.M003261200. ISSN 0021-9258. PMID 10934193.

Further reading



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