Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1gene.[1][2]
This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]
References
↑Gerecke DR, Olson PF, Koch M, Knoll JH, Taylor R, Hudson DL, Champliaud MF, Olsen BR, Burgeson RE (Jul 1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics. 41 (2): 236–42. doi:10.1006/geno.1997.4638. PMID9143499.
Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6". Genomics. 14 (2): 225–31. doi:10.1016/S0888-7543(05)80210-1. PMID1427837.
Wälchli C, Koch M, Chiquet M, et al. (1994). "Tissue-specific expression of the fibril-associated collagens XII and XIV". J. Cell Sci. 107 (2): 669–81. PMID8207089.
Berthod F, Germain L, Guignard R, et al. (1997). "Differential expression of collagens XII and XIV in human skin and in reconstructed skin". J. Invest. Dermatol. 108 (5): 737–42. doi:10.1111/1523-1747.ep12292122. PMID9129225.
Wessel H, Anderson S, Fite D, et al. (1997). "Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices". Invest. Ophthalmol. Vis. Sci. 38 (11): 2408–22. PMID9344363.
Chiquet M, Mumenthaler U, Wittwer M, et al. (1998). "The chick and human collagen alpha1(XII) gene promoter--activity of highly conserved regions around the first exon and in the first intron". Eur. J. Biochem. 257 (2): 362–71. doi:10.1046/j.1432-1327.1998.2570362.x. PMID9826181.
Trächslin J, Koch M, Chiquet M (1999). "Rapid and reversible regulation of collagen XII expression by changes in tensile stress". Exp. Cell Res. 247 (2): 320–8. doi:10.1006/excr.1998.4363. PMID10066359.
Gregory KE, Keene DR, Tufa SF, et al. (2002). "Developmental distribution of collagen type XII in cartilage: association with articular cartilage and the growth plate". J. Bone Miner. Res. 16 (11): 2005–16. doi:10.1359/jbmr.2001.16.11.2005. PMID11697796.
Saika S, Miyamoto T, Tanaka T, et al. (2002). "Collagens XII and XIV (FACITs) in capsular opacification and in cultured lens epithelial cells". Curr. Eye Res. 23 (6): 463–8. doi:10.1076/ceyr.23.6.463.6971. PMID12045897.
Jin X, Iwasa S, Okada K, et al. (2003). "Shear stress-induced collagen XII expression is associated with atherogenesis". Biochem. Biophys. Res. Commun. 308 (1): 152–8. doi:10.1016/S0006-291X(03)01344-5. PMID12890494.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Thierry L, Geiser AS, Hansen A, et al. (2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. 35 (8–9): 803–10. doi:10.1007/s10735-004-1132-y. PMID15609093.
Storlazzi CT, Wozniak A, Panagopoulos I, et al. (2006). "Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocation t(X;6)(q13-14;q22)". Int. J. Cancer. 118 (8): 1972–6. doi:10.1002/ijc.21586. PMID16284948.
