Irritable bowel syndrome differential diagnosis

Irritable bowel syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Differentiating Irritable Bowel Syndrome from other Diseases

American Gastroenterological Association Guidelines for Diagnosis of IBS

The American Gastroenterological Association has published a set of guidelines for tests which physicians should perform prior to diagnosing irritable bowel syndrome. The following tests are meant to exclude other causes, such as infection and colon cancer.

1. History and physical examination
2. Diagnostic testing
   1. CBC
   2. Chemistry panel
   3. Sedimentation rate
   4. Stool for O & P
   5. Stool for occult blood
   6. Flexible sigmoidoscopy
   7. IF > 50, colonoscopy or barium enema and sigmoidoscopy
   8. For diarrhea predominant:
      1. Small bowel radiograph
      2. Lactose/dextrose H2 breathing test
   9. For constipation predominant:
      1. Fiber trial
   10. For pain predominant:
       1. Plain film of abdomen

Diseases with similar symptoms

• Celiac disease
• Diverticulitis
• Endometriosis
• Gallstones
• Gastroesophageal reflux disease (GERD)
• Inflammatory bowel disease
• Lactose intolerance
• Thyroid disease